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Articles 1 - 12 of 12
Full-Text Articles in Life Sciences
Using Mixed Effects Modeling To Quantify Difference Between Patient Groups With Diabetic Foot Ulcers, Rachel French
Using Mixed Effects Modeling To Quantify Difference Between Patient Groups With Diabetic Foot Ulcers, Rachel French
Mahurin Honors College Capstone Experience/Thesis Projects
When diabetes progresses, many patients suffer from chronic foot ulcers. In a study described in Matrix Metalloproteinases and Diabetic Foot Ulcers (Muller et al., 2008), sixteen patients with diabetic foot ulcers were examined throughout a twelve week healing period. During this period, levels of matrix metalloproteinases (MMP-1), their inhibitors (TIMP-1), and the extracellular matrix in a wound area were measured at distinct time intervals for each patient. The ratios of these healing components are vital in determining whether a wound will heal or become chronic and never properly heal. Connecting Local and Global Sensitivities in a Mathematical Model for Wound …
Substrate-Borne Communication In Chameleons: Do Vibrations Induce Behavioral Changes?, Emily J. Hamilton
Substrate-Borne Communication In Chameleons: Do Vibrations Induce Behavioral Changes?, Emily J. Hamilton
Mahurin Honors College Capstone Experience/Thesis Projects
Understanding the modes of communication used by a species is essential to understanding their ecology, behavior, and evolution. Substrate-borne vibrations have been reported to be produced by the veiled chameleon (Chamaeleo calyptratus), possibly implemented by use of a gular pouch. We found that veiled chameleons produced vibrations under dominance and mating behavioral contexts. We tested the sensitivity of veiled chameleons to vibrations by placing chameleons, one at a time, on a wooden dowel attached to a permanent magnetic shaker and recording each chameleon’s behavior before, during, and after a three-pulse vibrational stimulus of 25, 50, 150, 300, or 600 Hz. …
Effect Assessment Of Tio2 Nanoparticles Exposure On Medicago By Monitoring Morphophysiology, Charles Towey
Effect Assessment Of Tio2 Nanoparticles Exposure On Medicago By Monitoring Morphophysiology, Charles Towey
Mahurin Honors College Capstone Experience/Thesis Projects
In recent years titanium dioxide nanoparticles (TiO2NPs) have been ingredients in everything from paints to cosmetics, and even in some kinds of food. This growth in use has resulted in a substantial increase in the amount of titanium released into the environment, which could have detrimental effects on nearby plant and animal life. Currently, the number of studies conducted on the effects of TiO2NPs is quite small, especially when it comes to edible crops. Because of this lack of research data, this study has been designed to assess the effect of TiO2 NPs exposure on …
Finding A Link Between Circadian Rhythms And The Immune System Of Captive Zebra Finches (Taeniopygia Guttata), Amber Bishop
Finding A Link Between Circadian Rhythms And The Immune System Of Captive Zebra Finches (Taeniopygia Guttata), Amber Bishop
Mahurin Honors College Capstone Experience/Thesis Projects
Circadian rhythms are commonplace in organisms and are normally controlled by a master clock. More recent evidence suggests that autonomous clocks operate in various systems in the body, including the immune system. This study looks for such a connection between the circadian rhythm and the immune system. In this study, captive zebra finches (Taeniopygia guttata) were exposed to different light and dark cycles and blood samples were taken every six hours. Birds were exposed to 12 hours of light and then 12 hours of darkness (LD), 24 hours of darkness (DD), or 48 hours of DD. After collecting …
Evaluating The Social Behavior And Activity Patterns Of Clouded Leopards (Neofelis Nebulosa) At The Nashville Zoo: Research And Literature Review, Meghan Ryckeley
Evaluating The Social Behavior And Activity Patterns Of Clouded Leopards (Neofelis Nebulosa) At The Nashville Zoo: Research And Literature Review, Meghan Ryckeley
Mahurin Honors College Capstone Experience/Thesis Projects
The behavior of the elusive clouded leopard (Neofelis nebulosa) is not well understood. In captivity, they are prone to exhibit stress-related behaviors and are often aggressive to conspecifics when paired. The present study built on past research by examining clouded leopards at the Nashville Zoo at Grassmere (NZG) to determine their activity patterns and temperament. Twelve leopards were exposed to familiar and unfamiliar objects and people, as well as their reflection in a mirror over nine trials. The males were often more reactive than the females, and the 5-year olds more reactive than their younger counterparts. The mirror …
The Validity Of Submaximal Exercise Testing In Obese Women, Gabrielle Ringenberg
The Validity Of Submaximal Exercise Testing In Obese Women, Gabrielle Ringenberg
Mahurin Honors College Capstone Experience/Thesis Projects
Background: Submaximal exercise tests use heart rate responses to low-to-moderate intensity activity in order to predict cardiorespiratory fitness (VO2max). Currently used tests may be inappropriate for obese populations as obese women have altered heart rate responses to exercise. The purpose of this project is to test the validity of the Modified Bruce Protocol submaximal treadmill test in obese women. Methods: Normal-weight (NWG) and obese women (OBG) completed the Modified Bruce submaximal treadmill test (to predict VO2max using previously validated equations) and a maximal graded exercise test on a treadmill using the Standard Bruce Protocol (to obtain an …
Analysis Of Population Structure In A California Newt (Taricha Torosa) Metapopulation, Jessica Vincent
Analysis Of Population Structure In A California Newt (Taricha Torosa) Metapopulation, Jessica Vincent
Mahurin Honors College Capstone Experience/Thesis Projects
As anthropogenic influences take an ever-increasing toll on the environment, understanding how environmental change affects species is paramount. Concern regarding decline in amphibian populations has spurred research examining the effects of habitat change on the dynamics of populations at landscape levels. One important goal is to understand how gene flow among populations is affected by changes in habitat. Biologists need to consider the relationship between gene flow and habitat alterations so that movements among individual breeding ponds can be maintained over time, reducing risk of local extinction events. This study focuses on patterns of gene flow among thirteen populations of …
Assessment Of Endpoint Criteria And Perceived Barriers During Maximal Cardiorespiratory Testing Among Pregnant Women, Caitlin Hesse
Assessment Of Endpoint Criteria And Perceived Barriers During Maximal Cardiorespiratory Testing Among Pregnant Women, Caitlin Hesse
Mahurin Honors College Capstone Experience/Thesis Projects
PURPOSE: Plateau in oxygen consumption (VO2) is the primary indicator for determining if an individual has reached their true maximal aerobic capacity (Howley et al., 1995). Although age and gender-specific secondary criteria (i.e. additional criteria that can be used to identify one’s attainment of maximal effort) have been developed for the healthy population, no secondary criteria have been established for pregnant women (Edvarsen et al., 2014). The primary purpose of this study was to analyze secondary endpoint criteria during VO2max testing among pregnant women during the 2nd trimester. A secondary purpose was to identify emotional and physical …
Detection Of Tetracyclines In An Anaerobic Waste Digester Using Solid Phase Extraction And High-Performance Liquid Chromatography Mass Spectrometry, Courtney Cruse
Mahurin Honors College Capstone Experience/Thesis Projects
Antibiotics are introduced to livestock to encourage growth and for the treatment of diseases. These antibiotics are not completely metabolized by swine, and thus these antibiotics are excreted with their waste. This poses a potential risk to human health as these antibiotics, a potential link to antibiotic resistant bacteria, then enter the surface water, ground water, and soil. In collaboration with the US Department of Agriculture (USDA) in Bowling Green, Kentucky, this research is concerned with analyzing the degradation of tetracyclines in swine waste from an anaerobic digester. Waste samples obtained from a digester and swine waste at the USDA …
An Approach To Identify Mycobacteriophage Diversity Prior To Dna Sequencing, Charles Gregory
An Approach To Identify Mycobacteriophage Diversity Prior To Dna Sequencing, Charles Gregory
Mahurin Honors College Capstone Experience/Thesis Projects
Over 6,869 Mycobacteriophages have been isolated and purified. Of these, 1,367 genomes have been sequenced at the DNA level and more are added each year through the SEA-PHAGES program. Sequenced mycobacteriophages are grouped into clusters based on a 50% or greater nucleotide identity. The number and breadth of these clusters represents the diversity present in the environment. Each year, as new phages are discovered by students in the SEA-PHAGES program, the question arises, “Which isolates should we sequence?” In order to sequence phages that represent the greatest possible diversity, and thus broaden under-represented clusters and identify new singletons, we need …
Investigating The Synergistic Effects Of Cisplatin And Two Curcuminoid Compounds On Cancer, Denis Hodzic
Investigating The Synergistic Effects Of Cisplatin And Two Curcuminoid Compounds On Cancer, Denis Hodzic
Mahurin Honors College Capstone Experience/Thesis Projects
Cisplatin is an anti-cancer drug effective against several cancers which can produce the serious side-effect of hearing loss. Curcumin, a natural plant compound, can increase the activity of cisplatin against cancer and counteract cisplatin’s effect against hearing. Because curcumin exhibits poor bioavailability, there is considerable interest in developing synthetic curcumin analogs (curcuminoids) that are more soluble and which retain anti-cancer activity and otoprotective function. This study investigated whether two curcuminoids, EF-24 and CLEFMA, increase the cytotoxic and ototoxic effects of cisplatin against the lung cancer cell line, A549, and the colorectal cancer cell line, Caco2. Cytotoxicity was measured by using …
Growth And Survival Of Salamanders Exposed To Different Formulations Of Glyphosate-Based Herbicide, Jessica Johnson
Growth And Survival Of Salamanders Exposed To Different Formulations Of Glyphosate-Based Herbicide, Jessica Johnson
Mahurin Honors College Capstone Experience/Thesis Projects
Amphibian populations have been experiencing rapid declines worldwide in the past few decades. There are many proposed causations, including the use of agricultural chemicals such as herbicides. Glyphosate based herbicides are one of the most widely used herbicides. This study looks at the effects of different brands of glyphosate-based herbicides, including those intended for aquatic use, on the survival and growth of axolotl salamander larvae. Out of four brands of glyphosate herbicide (Aquamaster, Aquaneat, Helosate plus, and Roundup Pro), the survival rates of Roundup Pro were the lowest. Most mortality occurred between the 3 mg/L and 6 mg/L concentrations, during …