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Circadian Rhythm Of Brain Gaba Levels In The Cockroach, Leucophaea Maderae, Juli Martin Mccay, Jeanette Marie Gibson
Circadian Rhythm Of Brain Gaba Levels In The Cockroach, Leucophaea Maderae, Juli Martin Mccay, Jeanette Marie Gibson
Mahurin Honors College Capstone Experience/Thesis Projects
Brain levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) were determined at three-hour intervals in roaches acclimated to a 12-hour lightl12-hour dark cycle (light onset 0600 h) at 25 ± 2° C using high performance liquid chromatography coupled with fluorometnc detection GABA levels were found to be highest at noon and lowest at 1800 h. A difference between the high and low levels at these two times remained during the second day under constant dark conditions, indicating that GABA levels do indeed vary on a circadian basis. Brain GABA levels were highest at a time of day that corresponded with …