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Articles 31 - 32 of 32
Full-Text Articles in Life Sciences
Neuronal Calcium Regulation And Cellular Stress In A Malignant Hyperthermia Disease Model, Jason Santiago
Neuronal Calcium Regulation And Cellular Stress In A Malignant Hyperthermia Disease Model, Jason Santiago
Electronic Theses and Dissertations
Calcium ions (Ca2+) are essential signaling molecules and must be carefully regulated to preserve specificity in function. One indispensible Ca2+ signaling protein is the ryanodine receptor (RyR) calcium release channel. RyR1 is essential for muscle contraction, and RyR1mutations can lead to severe muscle disorders such as malignant hyperthermia (MH). Recently, a mouse model of human MH (Y522S-RyR1) has been developed. In skeletal muscle, Y522S-RyR1 exhibits an increased sensitivity to activation resulting in Ca2+ leak, mitochondrial disorganization, and cellular stress. Although RyR1 expression is limited in the brain, the cerebellum may be particularly vulnerable to this disease because RyR1 is highly …
Purinergic Receptors In The Circumvallate Papillae Of Rats, Alana Marselle Montoya
Purinergic Receptors In The Circumvallate Papillae Of Rats, Alana Marselle Montoya
Electronic Theses and Dissertations
P2X2 receptors and P2Y4 receptors are ATP-activated cell surface receptors that gate movement of K+, Na+, and Ca2+. We used immunocytochemistry for P2X2 and P2Y4 receptors as well as taste cell type markers to learn if P2X2 immunoreactivity (IR) is present in nerve processes in close apposition to Type II and/or Type III taste cells. We also tested to see if P2Y4 IR is present in Type II and/or Type III taste cells. Our results indicate that P2X2 is present only in intragemmal nerve processes. P2X2-LIR nerve processes form close contacts with Type II and Type III taste cells. P2Y4 …