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Acetylation Controls Thyroid Hormone Receptor Intracellular Localization And Intranuclear Mobility, Cyril S. Anyetei-Anum
Acetylation Controls Thyroid Hormone Receptor Intracellular Localization And Intranuclear Mobility, Cyril S. Anyetei-Anum
Dissertations, Theses, and Masters Projects
Thyroid hormone receptor (TR) is responsible for mediating the expression of genes involved in growth, development, and homeostatic regulation, in response to thyroid hormone. There are two main subtypes of TR, TRα1 and TRβ1, that mediate these physiological processes. Dysregulation of TR mediated processes is a contributing factor in disease pathology. Our prior studies show that TR is shuttled rapidly between the nucleus and cytosol, while localizing primarily to the nucleus. TRα1 contains two nuclear localization signals (NLSs) that act together to confer strong nuclear localization, while TRβ1 only contains one NLS (NLS-1). Recently, we found that the intracellular localization …