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Full-Text Articles in Life Sciences
Reproductive Success Of Eastern Bluebirds (Siala Sialis) On Suburban Golf Courses, Kerri L. Cornell, Caitlin R. Kight, Ryan B. Burdge, Alex R. Gunderson, Joanna K. Hubbard, Allyson K. Jackson, Joshua E. Leclerc, Marie L. Pitts, John P. Swaddle, Daniel A. Cristol
Reproductive Success Of Eastern Bluebirds (Siala Sialis) On Suburban Golf Courses, Kerri L. Cornell, Caitlin R. Kight, Ryan B. Burdge, Alex R. Gunderson, Joanna K. Hubbard, Allyson K. Jackson, Joshua E. Leclerc, Marie L. Pitts, John P. Swaddle, Daniel A. Cristol
Arts & Sciences Articles
Understanding the role of green space in urban—suburban landscapes is becoming critical for bird conservation because of rampant habitat loss and conversion. Although not natural habitat, golf courses could play a role in bird conservation if they support breeding populations of some native species, yet scientists remain skeptical. In 2003–2009, we measured reproduction of Eastern Bluebirds (Siala sialis) in Virginia on golf courses and surrounding reference habitats, of the type that would have been present had golf courses not been developed on these sites (e.g., recreational parks, cemeteries, agriculture land, and college campus). We monitored >650 nest boxes …
Recruitment Of The Oncoprotein V-Erba To Aggresomes, Cornelius Bondzi, Abigail M. Brunner, Michelle R. Munyikwa, Crystal D. Conner, Et Al., Vincent R. Roggero, Lizabeth A. Allison
Recruitment Of The Oncoprotein V-Erba To Aggresomes, Cornelius Bondzi, Abigail M. Brunner, Michelle R. Munyikwa, Crystal D. Conner, Et Al., Vincent R. Roggero, Lizabeth A. Allison
Arts & Sciences Articles
Aggresome formation, a cellular response to misfolded protein aggregates, is linked to cancer and neurodegenerative disorders. Previously we showed that Gag-v-ErbA (v-ErbA), a retroviral variant of the thyroid hormone receptor (TRα1), accumulates in and sequesters TRα1 into cytoplasmic foci. Here, we show that foci represent v-ErbA targeting to aggresomes. v-ErbA colocalizes with aggresomal markers, proteasomes, hsp70, HDAC6, and mitochondria. Foci have hallmark characteristics of aggresomes: formation is microtubule-dependent, accelerated by proteasome inhibitors, and they disrupt intermediate filaments. Proteasome-mediated degradation is critical for clearance of v-ErbA and T3-dependent TRα1 clearance. Our studies highlight v-ErbA's complex mode of action: the oncoprotein is …