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Full-Text Articles in Life Sciences

Penetrance Estimates For Incidental Genomic Findings In Acmg-59, James A. Diao Jan 2017

Penetrance Estimates For Incidental Genomic Findings In Acmg-59, James A. Diao

Yale Day of Data

The dropping costs and rising popularity of next-generation sequencing has introduced the possibility of personalizing medical treatments and screening for genetic diseases. Still, the clinical community’s understanding remains incomplete, with limited consensus on the proper interpretation for many genetic variants. Thus, the standard procedure when returning sequencing results has been to report findings only in genes related to the diagnostic indication, and not incidental findings in other genes. To balance the threat of false positives with the medical benefits of true findings, the American College on Medical Genetics and Genomics (ACMG) recommends an exception: that clinical sequencing laboratories seek and …


Do Elephants Eat More Trees When Less Grass Is Available? A Field Study In Kruger National Park, South Africa., Emily Goldberg Jan 2017

Do Elephants Eat More Trees When Less Grass Is Available? A Field Study In Kruger National Park, South Africa., Emily Goldberg

Yale Day of Data

Although African bush elephants are often responsible for the majority of herbivore-driven savanna tree mortality, confusion remains regarding the factors that influence their diet. Some elephants either browse or graze almost exclusively, while others balance the two, and the determinants of this variation remain poorly understood. I seek to determine whether grass availability controls the proportion of woody plants in elephant diet and, therefore, the amount of damage elephants do to trees while foraging. Preliminary analysis using already-available data on grass biomass, elephant density, and elephant damage to trees suggest that tree damage is in fact negatively correlated with grass …