Life Sciences Commons^™

Modeling Virus Coinfection To Inform Management Of Maize Lethal Necrosis In Kenya, Frank H. Hilker, Linda S. J. Allen, Vrushali A. Bokil, Cheryl J. Briggs, Zhilan Feng, Karen A. Garrett, Louis J. Gross, Frédéric M. Hamelin, Michael J. Jeger, Carrie A. Manore, Alison G. Power, Margaret G. Redinbaugh, Megan A. Rúa, Nik J. Cunniffee

Biological Sciences Faculty Publications

Maize lethal necrosis (MLN) has emerged as a serious threat to food security in sub-Saharan Africa. MLN is caused by coinfection with two viruses, Maize chlorotic mottle virus and a potyvirus, often Sugarcane mosaic virus. To better understand the dynamics of MLN and to provide insight into disease management, we modeled the spread of the viruses causing MLN within and between growing seasons. The model allows for transmission via vectors, soil, and seed, as well as exogenous sources of infection. Following model parameterization, we predict how management affects disease prevalence and crop performance over multiple seasons. Resource-rich farmers with …

Phytochemical Screening And Determination Of Antibacterial, Anti-Tumorigenic And Dna Protection Ability Of Root Extracts Of Saussurea Lappa, Sughra Arif Minhas, Fida Muhammad Khan, Fakhar-I- Abbas, Abu Ul Hassan Faiz

Journal of Bioresource Management

Saussurea lappa is a traditionally well-known plant for its medicinal uses in different indigenous systems of medicine. It is widely used in the treatment of asthma, ulcer, stomach problems and inflammatory diseases. In current study the phytochemical screening of S. lappa showed the presence of sesquiterpenes, anthraquinones, lignans, alkaloids, flavonoids, glycosides and steroids. Antimicrobial potential of subject plant was also investigated against three bacterial strains and maximum antibacterial activity was observed by CEE against S. aureus, CAE against P. aeruginosa, while CME, CEE, EAE and PEE showed almost same significant activity against E. coli. The CME (1000 …

New Record Of Asian Pied Starling (Gracupica Contra Contra) From Kalar Kahar (Pakistan), Usman Hanif, Fakhar-I- Abbas, Zahid Iqbal Khan, Afsar Mian

Journal of Bioresource Management

A pair of Asian Pied Starling or Pied Myna (Gracupica contra contra) was sighted in reed vegetation present around Kalar Kahar Lake (northwestern Salt Range, Pakistan). Subspecies has been sighted for the first time west of Sialkot and Lahore. Further studies are required to determine the status of the population of the subspecies in Kalar Kahar to suggest an extension in distribution range of the species.

Rehabilitation Of An Injured Golden Eagle (Aquila Chrysaetos): A Case Study, Fida Muhammad Khan, Fakhar-I- Abbas, Abu Ul Hassan Faiz

Journal of Bioresource Management

Habitat destruction and anthropogenic activities cause wild birds to migrate towards urban areas in search of food and sometimes nesting in high-roof buildings, where they are caught by local people using different techniques and are further used for hunting or recreational purposes. An injured Golden Eagle (Aquila chrysaetos) was found entangled in bushes near the vicinity of Balkasar Research Complex, Chakwal, Pakistan. After complete physical examination, a wound on the right wing and closed leg fracture was diagnosed. The successful treatment was done by anti-parasitic and anti-bacterial drugs with careful monitoring. Splint was adjusted after aligning the fractured …

Characterization Of Different Molecular Markers For Identification Of Salmonella Enterica Serovar Typhi In Pakistani Population, Faizan Muttiullah, Fida Muhammad Khan, Fakhar-I- Abbas, Sabiha Shamim

Journal of Bioresource Management

Typhoid is caused by Salmonella enterica serovar Typhi that is usually diagnosed by using serologic and immuno-chromatographic techniques in developing counties including Pakistan, which is thought to be an unreliable diagnostic method. For accurate diagnosis we used molecular techniques to amplify 204 bp StyR-36 and 498 bp flagellin gene for the identification of Salmonella enterica serovar Typhi. This study was done on 58 individuals diagnosed positive of typhoid via serologic tests and 50 healthy individuals as a control group. Success rate of amplification for flagellin gene was 77.58% while that for StyR-36 gene was 68.97% showing that flagellin gene primer …

Allergen Homologs In The Euroglyphus Maynei Draft Genome, S. Dean Rider, Majorie S. Morgan, Larry G. Arlian

Biological Sciences Faculty Publications

Euroglyphus maynei is a house dust mite commonly found in homes worldwide and is the source of allergens that sensitize and induce allergic reactions in humans. It is the source of species-specific allergens as well as allergens that are cross-reactive with the allergens from house dust mites Dermatophagoides farinae and D. pteronyssinus, and the ectoparasitic scabies mite Sarcoptes scabiei. The genomics, proteomics and molecular biology of E. maynei and its allergens have not been as extensively investigated as those of D. farinae, D. pteronyssinus, and S. scabiei where natural and recombinant allergens from these species have been characterized. Until now, …

Discovering Explanatory Models To Identify Relevant Tweets On Zika, Roopteja Muppalla, Michele Miller, Tanvi Banerjee, William L. Romine

Kno.e.sis Publications

Zika virus has caught the worlds attention, and has led people to share their opinions and concerns on social media like Twitter. Using text-based features, extracted with the help of Parts of Speech (POS) taggers and N-gram, a classifier was built to detect Zika related tweets from Twitter. With a simple logistic classifier, the system was successful in detecting Zika related tweets from Twitter with a 92% accuracy. Moreover, key features were identified that provide deeper insights on the content of tweets relevant to Zika. This system can be leveraged by domain experts to perform sentiment analysis, and understand the …

A Knowledge Graph Framework For Detecting Traffic Events Using Stationary Cameras, Roopteja Muppalla, Sarasi Lalithsena, Tanvi Banerjee, Amit Sheth

Kno.e.sis Publications

With the rapid increase in urban development, it is critical to utilize dynamic sensor streams for traffic understanding, especially in larger cities where route planning or infrastructure planning is more critical. This creates a strong need to understand traffic patterns using ubiquitous sensors to allow city officials to be better informed when planning urban construction and to provide an understanding of the traffic dynamics in the city. In this study, we propose our framework ITSKG (Imagery-based Traffic Sensing Knowledge Graph) which utilizes the stationary traffic camera information as sensors to understand the traffic patterns. The proposed system extracts image-based features …

Human Biomechanics Ii Course Project, Abdelaziz Mohammad

Best Integrated Writing

Mohammad tested Human Arm Module PASCO ME-6807A, in order to determine some of the biomechanical characteristics, such as force, tension, instantaneous angular velocity, and acceleration vs. angular position required for various movements and arm positions in space.

The Effects Of Nitrogen And Potassium On The Growth Of Brassica Rapa, Kimberly Truong

Best Integrated Writing

Truong conducted an experiment to observe the effect that nitrogen and potassium from organic sources has on plant growth. Truong makes suggestions for further research.

La Crisis Ignorada, Joseph Pokorski

Best Integrated Writing

Pokorski researched the food production practices of pre-Columbian civilizations. He uses his research to evaluate the current food production practices of transnational corporations and offers suggestions for best practices.

Best Integrated Writing 2017 - Complete Edition

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University. The journal is published annually by the Wright State University Department of English Language and Literatures.

Identification Of Antigenic Sarcoptes Scabiei Proteins For Use In A Diagnostic Test And Of Non-Antigenic Proteins That May Be Immunomodulatory, Majorie S. Morgan, S. Dean Rider, Larry G. Arlian

Biological Sciences Faculty Publications

Background

Scabies, caused by the mite, Sarcoptes scabiei, infects millions of humans, and many wild and domestic mammals. Scabies mites burrow in the lower stratum corneum of the epidermis of the skin and are the source of substances that are antigenic or modulate aspects of the protective response of the host. Ordinary scabies is a difficult disease to diagnose.

Objective

The goal of this project was to identify S. scabiei proteins that may be candidate antigens for use in a diagnostic test or may be used by the mite to modulate the host’s protective response.

Methods

An aqueous …

Animals And Their Epibiota As Net Autotrophs: Size Scaling Of Epibiotic Metabolism On Snail Shells, Nicole Lukens, Benjamin Kraemer, Vanessa Constant, Ellen J. Hamann, Ellinor Michel, Anne M. Socci, Yvonne Vadeboncoeur, Peter B. Mcintyre

Biological Sciences Faculty Publications

Animals are heterotrophic by definition, but species from many taxonomic groups are hosts to epibiota that may alter their net metabolism. We tested the degree to which snail-shell epibiota can generate net ecosystem productivity for snails and their epibiota (snail–epibiota ecosystems; SEEs) after accounting for snail respiration. We focused on 3 species from the Lavigeria snail assemblage in Africa’s Lake Tanganyika and quantified the scaling of SEE metabolism with shell size under light and dark conditions. The metabolism of snails and their epibiota shifted significantly across the size gradient. SEEs of large snails (>20 mm) were consistently autotrophic during …

Assessment Of Functional Movement Screening™ By Assessors Of Three Different Skill Levels, Mackenzie Cole, Marissa Mccollister, Neil Greier, Siobhan Fagan, Andrew W. Froehle, Nicholas Curry, Jason Bradford, Brad Muse, Scott Bruce

Kinesiology and Health Faculty Publications

• The Functional Movement Screen (FMS) is a series of 7 physical tests

• FMS screens fundamental movement patterns that require mobility, stability, and motor control

• FMS is comprised of deep squat (DS), hurdle step (HS), in-line lunge (IL), shoulder mobility (ShM), active straight leg raise (ASLR), trunk stability push-up (TSP), and rotary stability (RS) (Figures 1-4)

• Sports medicine clinicians use FMS to assess for dysfunctional movement patterns

• FMS is not intended to be a diagnostic tool

• The inter-rater reliability for FMS has values ranging from 0.37 to .95

• The intra-rater reliability for FMS has …

Khealth Bariatrics: A Multisensory Approach To Monitoring Patient’S Postsurgical Behavior, Revathy Venkataramanan, Utkarshani Jaimini, Amit Sheth, Joon K. Shim, Priti Parikh, Dene S. Berman

Symposium of Student Research, Scholarship, and Creative Activities Materials

The rate of obesity is on the rise reaching epidemic proportions. According to American Society for Metabolic and Bariatric Surgery (ASMBS), 500 million people all over the world are obese. The data from Centers for Disease Control and Prevention(CDC) shows that more than 36% of adults in the United States have obesity. According to World Health Organization (WHO), 65% of the world’s population lives in countries where the occurrence of death due to overweight and obesity is higher than being underweight. It is well established that weight loss surgery can play a significant role in reducing, or even eliminating medical …

Measuring Gender-Based Violence Attitude On Twitter, Goonmeet Bajaj, Tanvi Banerjee, Amir Hossein Yazdavar, Valerie L. Shalin, Amit Sheth

Symposium of Student Research, Scholarship, and Creative Activities Materials

This study examines social media to analyze communication patterns, specifically in the Gender-Based Violence domain. It explores the pragmatic content of tweets to categorize them into one of the following groups: Belief, Fact Reporting, or Other to determine the tweeting practices prevalent in this domain.

Legalization Of Gay Marriage And Its Impact On Military Stereotypes Of Homosexuals, Jasmine Moore

Symposium of Student Research, Scholarship, and Creative Activities Materials

Homosexuality has become a popular research topic in a variety of professional fields, and over the last decade has become a priority for the military. Since the implementation of the law repealing Don't Ask Don't Tell (DADT) researchers have questioned what effects repealing this law has had on the military as a whole. Particular attention has been spent on studying the attitudes and stereotypes about homosexuals after DADT was repealed. However, there is a lack of research examining how marriage equality affects society's stereotypes about homosexuals serving in the United States military.

It was hypothesized that participants that have personal …

Wright State University's Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts From Friday, April 21, 2017, Wright State University

Symposium of Student Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Annual Celebration of Research, Scholarship and Creative Activities on April 21, 2017.

Treating Chronic Post Herpetic Neuralgia Using Topical Superconcentrated Capsaicin, Jaree Naqvi, Scott Seider, Jason Miller, Cole Budinsky, Amol Soin

Symposium of Student Research, Scholarship, and Creative Activities Materials

Post Herpetic Neuralgia (PHN) is a painful condition that occurs after reactivation of the dormant Herpes Zoster Virus.Typically PHN presents with a unilateral rash affecting a single dermatome which is accompanied by burning, irritation, and hypersensitivity for >3 months.Current treatment includes anticonvulsants, tricyclic antidepressants, narcotic/nonnarcotic painkillers, and topical lidocaine.

We propose the utilization of a superconcentrated transdermal patch of capsaicin called Qutenza 8%, which is 300 times more potent than current OTC capsaicin. The treatment protocol using Qutenza to treat refractory PHN proposes a novel approach to the treatment of this condition.

Capsaicin is commonly known as the active chemical …

Social Workers’ Salaries Vs. Educational Student Debt Burden: A Losing Battle, Michael Wadham

Symposium of Student Research, Scholarship, and Creative Activities Materials

College tuitions rise at disparate rates with starting salaries and inflation, causing student debt to weigh on social work graduates. Data was collected from 701 social workers in an NASW - Ohio Chapter survey to investigate this disparity and its consequences. The purpose of this study was to analyze the qualitative data set, 174 written comments, for themes and perceptions. The following themes, echoed in current research on the topics of social work salary and student debt burden, were identified: unmanageable debt and financial burden, varying lengths of time and repayment methods, social workers feeling undervalued and underpaid, loan forgiveness …

Eassistant: Cognitive Assistance For Identification And Auto-Triage Of Actionable Conversations, Hamid R. Motahari Nezhad, Kalpa Gunaratna, Juan Cappi

Kno.e.sis Publications

The browser and screen have been the main user interfaces of the Web and mobile apps. The notification mechanism is an evolution in the user interaction paradigm by keeping users updated without checking applications. Conversational agents are posed to be the next revolution in user interaction paradigms. However, without intelligence on the triage of content served by the interaction and content differentiation in applications, interaction paradigms may still place the burden of information overload on users. In this paper, we focus on the problem of intelligent identification of actionable information in the content served by applications, and in particular in …

What Are People Tweeting About Zika? An Exploratory Study Concerning Its Symptoms, Treatment, Transmission, And Prevention, Michele Miller, Tanvi Banerjee, Roopteja Muppalla, William L. Romine, Amit Sheth

Kno.e.sis Publications

Background: In order to harness what people are tweeting about Zika, there needs to be a computational framework that leverages machine learning techniques to recognize relevant Zika tweets and, further, categorize these into disease-specific categories to address specific societal concerns related to the prevention, transmission, symptoms, and treatment of Zika virus.

Objective: The purpose of this study was to determine the relevancy of the tweets and what people were tweeting about the 4 disease characteristics of Zika: symptoms, transmission, prevention, and treatment.

Methods: A combination of natural language processing and machine learning techniques was used to determine what people were …

An Attempt To Update A Checklist And Some Other Aspects Of Murree Hills’ Avifauna, Abulhasan Faiz, Fakhar -I- Abbas, Adila Nazli, Fakhra Nazir

Journal of Bioresource Management

Birds are vital component of biodiversity as they are playing a significant role in an ecosystem. Increasing human interference might have affected previously reported diversity of birds. This study was designed to collect information about birds check list data of Murree hills. Area was surveyed at different times of day and different months of season. During visits, pictures of birds were taken and identification as well as preparation of list was carried out. Comparison of new checklist with previous literature was done in order to get revised checklist of existing species.

A Check List Of The Avifauna Of Loi-Bher Wildlife Park Islamabad, Madeeha Manzoor, Sabiha Shamim, Fida Muhammad Khan

Journal of Bioresource Management

Despite its relatively small area, Loi-Bher wild life park is quite diverse with respect to the avifauna. The common bird species found in the area are: bulbuls, pies, pigeons, parakeets, mynas, babblers, warblers, rollers, bee-eaters, doves, crows and pheasants. Over 40 species of Broad-leaved trees, shrubs and woody climbers have been identified in this zone e.g. Acacia modesta, Morus alba, Bauhinia variegata, Punica granatum, Aristida cynnantha, Acacia nilotica, Dalbergia sisso, etc. Human settlements in designated natural areas of the Loi-Bher wild life park constitute the most serious threat to the park resources.

A Study On The Birds Of Urban Islamabad In Moonsoon Season, Ehjaz Raza Abbas, Sabiha Shamim, Fida Muhammad Khan

Journal of Bioresource Management

Every species constituting the fauna of an environment plays an important role in various aspects of Ecology. Cataloging of available diversity provides base line for any advancement in conservation. This study was designed to gather information from the field and literature to formulate a checklist of birds. Compartments of study area were visited on appropriate timing and compared with available literature. A checklist was formulated. Comparisons with the existing lists were made and the new distribution of birds was reported.

A Revision And Pectoral Guide To The Checklist Of Birds Of Salt Range, Zahid Iqbal Khan, Adila Nazli, Fakhra Nazir, Madeeha Manzoor

Journal of Bioresource Management

Birds as major important component of biodiversity provide a vital aspect of nature’s beauty and completes important ecological role in ecosystem. Current study was designed to gather baseline information about birds of salt range which tends to be modifying with the passage of time. The area was surveyed, pictures of birds were taken and after identification a checklist was formulated and changes in biodiversity was notified.

Δnp63Α And Microrna: Leveraging The Epithelial-Mesenchymal Transition, Andrew J. Stacy, Michael P. Craig, Suraj Sakaram, Madhavi Kadakia

Biochemistry and Molecular Biology Faculty Publications

The epithelial-mesenchymal transition (EMT) is a cellular reprogramming mechanism that is an underlying cause of cancer metastasis. Recent investigations have uncovered an intricate network of regulation involving the TGFβ Wnt, and Notch signaling pathways and small regulatory RNA species called microRNAs (miRNAs). The activity of a transcription factor vital to the maintenance of epithelial stemness, ?Np63a, has been shown to modulate the activity of these EMT pathways to either repress or promote EMT. Furthermore, ?Np63a is a known regulator of miRNA, including those directly involved in EMT. This review discusses the evidence of ?Np63a as a master regulator of EMT …

A Novel Molecular Relationship Between Parn And Pld That, When Deregulated, Contributes To The Aggressive Phenotype Of Breast Cancer Cell Lines., Taylor Elaine Miller

Browse all Theses and Dissertations

The removal of mRNA transcript poly(A) tails by 3'-5' exonucleases is the rate-limiting step for controlled mRNA decay in eukaryotes. Poly(A)-specific ribonuclease (PARN) is one such exonuclease that degrades poly(A) tails, and although its in vitro activity is well-characterized, PARN’s patho-physiological roles in the cell are not well understood. Prior studies have found a possible role for PARN in cancer, in that PARN expression levels in human breast cancer tissues are often decreased compared to normal control tissues. Indeed, data mined from the ONCOMINE cancer array database showed that PARN is downregulated in patient invasive breast carcinoma samples compared to …

Genomic Vs. Non-Genomic Role Of The Ahr In Human Immunoglobulin Expression, Nasser Alhamdan

Browse all Theses and Dissertations

The immunoglobulin heavy chain gene (Igh) in various animal models is regulated by numerous regulatory elements including the 3’Igh regulatory region (3’IghRR). Several transcription factors are involved in modulating the 3’IghRR including the aryl hydrocarbon receptor (AhR). The AhR is a ligand-activated transcription factor that mediates the transcription of genes involved in the metabolism of environmental toxicants such as TCDD. TCDD binds AhR and regulates immunoglobulin (Ig) expression in B cells. This modulation appears to be directly mediated by binding of the AhR to dioxin response elements (DRE) within the 3’IghRR. In human B cells, IgG secretion inhibited by TCDD …