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Effects Of Fluoxetine/Simvastatin/Ascorbic Acid Combination Treatment On Neurogenesis And Functional Recovery In A Model Of Multiple Sclerosis, Olivia Cameron Webb
Effects Of Fluoxetine/Simvastatin/Ascorbic Acid Combination Treatment On Neurogenesis And Functional Recovery In A Model Of Multiple Sclerosis, Olivia Cameron Webb
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Whereas immune modulation has proven beneficial in multiple sclerosis (MS), we hypothesized that targeting down-stream modulators of neurogenesis and subsequent remyelination may offer an additional, if not superior, point of intervention in an attempt to repair damage and recover lost function. As such, the present study assessed the effectiveness of 30-day administration of the drug combination fluoxetine (5 mg/kg), simvastatin (1 mg/kg), and ascorbic acid (50 mg/kg) (FSA) on an early marker of neurogenesis, doublecortin (DCX), and functional recovery using the Montoya Staircase following lysolecithin-induced focal demyelination of the corpus callosum in middle-aged (10-11 month) male and female rats. Lysolecithin …
A Novel Method For Analysis Of Proprioceptor Sensory Neuron Subtypes In The Mouse Dorsal Root Ganglia, Delaney C. Grant
A Novel Method For Analysis Of Proprioceptor Sensory Neuron Subtypes In The Mouse Dorsal Root Ganglia, Delaney C. Grant
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Proprioceptive sensory neurons encode critical mechanosensory information that helps determine how the body interacts with the outside world and monitors the proper execution of motor movements. Housed in skeletal muscles lie specialized mechanoreceptors that are critical to this feedback loop: muscle spindles supplied by group Ia & group II afferents, and Golgi tendon organs supplied by group Ib afferents relay information regarding changes in muscle force, length, and tension. All three afferent subtypes originate in the muscle and travel to the dorsal root ganglia, relaying information to the central nervous system. GTO and MS proprioceptive afferent subtypes have been identified, …