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Full-Text Articles in Life Sciences
Prenatal Programming Of Hepatic Glucose And Cholesterol Regulation In Male Rat Offspring By Chronic Intermittent Hypoxia, Waseem Iqbal
Prenatal Programming Of Hepatic Glucose And Cholesterol Regulation In Male Rat Offspring By Chronic Intermittent Hypoxia, Waseem Iqbal
Electronic Thesis and Dissertation Repository
Obstructive sleep apnea (OSA) is a chronic disorder involving repetitive interruptions in breathing during sleep. Sufferers of OSA are exposed to chronic intermittent hypoxia (CIH), characterized by cyclical reductions in oxygen availability. A number of studies have established a link between OSA and various cardiovascular and metabolic comorbidities in adulthood, including hypertension, obesity, and type II diabetes. While the consequences of OSA in adults have been well described, the cross-generational impact of this condition and potential effects on fetal development are not known. Epidemiological and animal studies have demonstrated that physiological insults during pregnancy lead to diminished growth of offspring …
The Role Of The Liver X Receptor (Lxr) In The Fetal Programming Of Hepatic Gluconeogenesis, (Peter) Thin X. Vo
The Role Of The Liver X Receptor (Lxr) In The Fetal Programming Of Hepatic Gluconeogenesis, (Peter) Thin X. Vo
Electronic Thesis and Dissertation Repository
Chronic diseases such as type 2 diabetes and the Metabolic Syndrome create enormous burdens on society. Epidemiological studies now strongly implicate intrauterine growth restriction (IUGR) for increasing the risk of developing chronic diseases later on in life. However, the molecular mechanisms underlying how IUGR leads to the increased susceptibility to these metabolic diseases in adulthood is not well understood. The Liver-X-Receptor (LXR) is a nuclear receptor involved in cholesterol, glucose, and lipid metabolism. LXR acts to decrease gluconeogenesis through repression of glucose-6-phosphatase(G6Pase), phosphoenolpyruvate carboxykinase(PEPCK), and 11β-hydroxysteroid dehydrogenase type-1(11β-HSD1). Using a well-characterized model of maternal protein restriction in rats, this study …
Hypoxia-Induced Alterations In Skeletal Muscle Cell Respiration And Resveratrol As A Potential Pharmacological Intervention, Kathleen R. Belgrave
Hypoxia-Induced Alterations In Skeletal Muscle Cell Respiration And Resveratrol As A Potential Pharmacological Intervention, Kathleen R. Belgrave
Electronic Thesis and Dissertation Repository
Using the C2C12 mouse muscle myoblast cell line, I sought to investigate the hypothesis that differentiation under hypoxia impairs muscle mitochondrial respiratory function irreversibly. Resveratrol (RSV) will increase expression of markers of mitochondrial biogenesis and reverse the hypoxia-induced depression of O2 consumption rates. Hypoxia decreased oxygen consumption rates after five days of differentiation and after two days of normoxic recovery. This coincided with a hypoxia-induced decrease in protein levels of the NDUFB8 subunit of complex I of the electron transport chain and decreases in mRNA levels of mitochondrial biogenesis transcription factors, both of which could contribute …