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Full-Text Articles in Life Sciences
Possible Mechanisms Behind Impaired Glucose Metabolism In Niacin-Deficient Mice, Sierra Lopez
Possible Mechanisms Behind Impaired Glucose Metabolism In Niacin-Deficient Mice, Sierra Lopez
Student Research Symposium
Niacin, a component of vitamin B3, is necessary for the synthesis of nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme in many biologic functions, including a number of metabolic processes that regulate glucose and fat homeostasis. Humans obtain niacin in its dietary form, common in meats, nuts, legumes and some leafy vegetables. While severe niacin deficiency, or pellagra, has been drastically reduced in the United States, some populations remain vulnerable to deficiency, particularly pregnant women, cancer patients, the elderly and alcoholics. Age-related NAD deficiency is emerging as being positively correlated with cognitive decline and impaired dermal repair.. At the …
Detecting Dna Oxidation In Sperm, Alexie Zwerdling
Detecting Dna Oxidation In Sperm, Alexie Zwerdling
Student Research Symposium
Declining body-wide levels of nicotinamide adenine dinucleotide (NAD) that are present in normal aging men are linked to decreased sperm quality and DNA integrity. When NAD is low, the amount of oxidative stress on the DNA appears to be increased, due to the limited regeneration of the antioxidant glutathione, which is NAD-dependent. We therefore hypothesize that the increased sperm DNA damage in the aging male is caused by an elevated formation of 8-oxoguanine in the DNA, caused by increased oxidative stress when NAD levels are low. To test this hypothesis, a transgenic mouse model (ANDY mouse) was used to create …
Roles Of Nad In Dna Repair And Response To Oxidative Stress, Micah Forbush
Roles Of Nad In Dna Repair And Response To Oxidative Stress, Micah Forbush
Student Research Symposium
It has become a common trend for people to start their families at a later age, often due to lifestyle choices like achieving career goals first and waiting to achieve financial stability. Along with this trend of increasing parental age comes another, the decrease in fertility. While it is well established that female fertility declines significantly with age, current research is showing that male fertility may be impacted just as much. NAD (Nicotinamide Adenine Dinucleotide) is an important biochemical cofactor in most metabolic reactions, and importantly, is it also essential for DNA repair. As age increases in humans, the amount …