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Pharmacological Characterization Of The Oxytocin Receptor Antagonist L-368,899 For Coyote Receptors, Mckenna Rich, Hillary Ihrig
Pharmacological Characterization Of The Oxytocin Receptor Antagonist L-368,899 For Coyote Receptors, Mckenna Rich, Hillary Ihrig
Student Research Symposium
The neurohormone oxytocin influences many physiological pathways in animals, aiding in social behaviors, pair bonding, social recognition, and maternal behavior. A common strategy used to observe the influence of oxytocin on these behaviors is to disrupt oxytocin signaling, by blocking the oxytocin receptor (OXTR). This blockade can be achieved using antagonists which bind to the receptor and inhibit the subsequent activation of intracellular signaling pathways. We aimed to determine whether the commercially-available OXTR antagonist L-368,899 selectively binds to OXTR in coyote brains. L-368,899 selectively binds to OXTR in primates and has been used in animal behavior studies to block oxytocin-dependent …
Comparing L-368,899 And Als-Iii-61 As Human-Selective Oxytocin Receptor Antagonists, Blake Nielson, Matthew Webb
Comparing L-368,899 And Als-Iii-61 As Human-Selective Oxytocin Receptor Antagonists, Blake Nielson, Matthew Webb
Student Research Symposium
Oxytocin is a neuropeptide that influences social behavior in animals and humans. One way to test the effects of oxytocin on social behavior is by blocking oxytocin receptors (OXTR) with an antagonist. The commercially-available OXTR antagonist L-368,899 (the “Merck compound”) is commonly used for such studies despite inadequate evidence of its affinity and selectivity for OXTR in the brain. The Freeman Lab has used the custom-synthesized antagonist ALS-III-61 (the “Smith compound”), which has high specificity and affinity for OXTR in the brain but is not commercially available. Due to our diminishing supply of the Smith compound, we sought evidence that …