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Articles 1 - 30 of 32
Full-Text Articles in Life Sciences
The Role Of The Circadian Clock In The Intestinal Epithelium During Health, Regeneration, And Tumourigenesis, Kyle Stokes
The Role Of The Circadian Clock In The Intestinal Epithelium During Health, Regeneration, And Tumourigenesis, Kyle Stokes
Electronic Theses and Dissertations
The Earth’s axial rotation subjects its surface to constant periods of light and dark, this is known as photoperiod. Many organisms have adapted their physiology in accordance with this environmental constant by generating 24h rhythms in their physiological functions; these are known as circadian rhythms. Circadian rhythms are controlled by an endogenous time-keeping mechanism known as the circadian clock. Over 40% of the genome in mice and over 80% of the genome in primates has been shown to have 24h rhythms in transcription. The disruption of circadian rhythms through shiftwork, jetlag, or exposure to light at night is associated with …
A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba, Thomas Alexander
A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba, Thomas Alexander
Electronic Theses and Dissertations
In this thesis, we are interested in finding the best drugs that can be repurposed for the disease and able to find the adverse effects such drugs that are FDA-Approved. Developing an effective drug can be a time-consuming and expensive crucible method. Network-based machine learning methods are used for predicting a given drug for A that can be used for B. It aims at finding new indications for already existing drugs and therefore increases the available therapeutic choices at a fraction of the cost of new drug development. The perturbation gene expression data corresponding to the MCF7 cell line was …
Population Genetic Analyses Of Arctic Char (Salvelinus Alpinus) Life History Types In Nettilling Lake & Amadjuak River Ecosystem: A Test Of Reproductive Isolation, Chen Liu
Electronic Theses and Dissertations
A great number of studies have identified strong genetic differences between sympatric anadromous and resident populations of Salmonidae. However, Arctic char (Salvelinus alpinus) migratory phenotypes in the Nettilling Lake and Amadjuak River ecosystem in Nunavut, Canada have not been genetically characterized, and it remains unclear if distinct genotypes and phenotypes associated with migratory life history differences are maintained through reproductive isolation, and they have been assumed to be sympatric populations, or co-occurring populations. Co-occurring Arctic char (n=225) were sampled from eleven sites along the Amadjuak River in 2014 and 2015. Twelve microsatellite loci were used to quantify genetic variation among …
University Students Using Physical Activity As A Coping Strategy During The Covid-19 Pandemic, Jory Fulcher
University Students Using Physical Activity As A Coping Strategy During The Covid-19 Pandemic, Jory Fulcher
Electronic Theses and Dissertations
The Coronavirus Disease 2019 (COVID-19) pandemic is the most recent threat to global health (Fauci, Lane, & Redfield, 2020), impacting university students’ mental and physical health. Few studies currently exist that investigate the impact of online learning and COVID-19 have on stress and coping in university students (Bao, 2020; Xiao et al., 2020). Therefore, the purpose of the study was to investigate if students were using physical activity as a coping strategy for stress during the COVID-19 pandemic. An online survey assessing student stress, physical activity, and coping flexibility was completed by 276 undergraduate students (mean age 21.1 ± 2.7 …
Lower Trophic Relations Within The Lake Ontario Invertebrate Community As Assessed By Chemical Tracers, Donald Robert Uzarski
Lower Trophic Relations Within The Lake Ontario Invertebrate Community As Assessed By Chemical Tracers, Donald Robert Uzarski
Electronic Theses and Dissertations
The lower trophic food web of Lake Ontario plays an important role in the lake’s ecosystem, yet the trophic relationships of these taxa are not well understood. Utilizing carbon (δ13C) and nitrogen (δ15N) stable isotopes as a tool to trace the flow of energy through the system, the main objective of this thesis was to understand the isotopic variability and trophic relationships of invertebrate taxa through space and season in Lake Ontario. Using an extensive dataset collected in 2012 and 2013, this study was conducted in two research chapters. The first chapter assessed variation in the isotopic signature of three …
Deep Learning Applications In Medical Bioinformatics, Ziad Omar
Deep Learning Applications In Medical Bioinformatics, Ziad Omar
Electronic Theses and Dissertations
After a patient’s breast cancer diagnosis, identifying breast cancer lymph node metastases is one of the most important and critical factor that is directly related to the patient’s survival. The traditional way to examine the existence of cancer cells in the breast lymph nodes is through a lymph node procedure, biopsy. The procedure process is time-consuming for the patient and the provider, costly, and lacks accuracy as not every lymph node is examined. The intent of this study is to develop an artificial neural network (ANNs) that would map genetic biomarkers to breast lymph node classes using ANNs. The neural …
Physiological State Determinants Of Maternal Cortisol Signaling And Its Impact On Offspring Quality And Fitness, Sydney Currier
Physiological State Determinants Of Maternal Cortisol Signaling And Its Impact On Offspring Quality And Fitness, Sydney Currier
Electronic Theses and Dissertations
Assessing the intergenerational effects of maternal stress is important for predicting how offspring will respond to changing environments. The overall aim of my thesis was to quantify the effects of maternal state on maternally derived egg cortisol and determine whether this variation in egg cortisol impacts Chinook salmon offspring performance and fitness in a sex-specific way. I quantified within-female changes in maternal energetics and reproductive metrics that I linked to egg quality and ultimately embryo survival. I found egg cortisol increases with increasing maternal plasma cortisol, and increases further as plasma cortisol levels rise with each day that eggs are …
Examining The Combined Impacts Of Rapid Senescence And A Low Water Stressor On Maternal State, Egg Quality, And Fitness In Chinook Salmon, Madison A. Sturba
Examining The Combined Impacts Of Rapid Senescence And A Low Water Stressor On Maternal State, Egg Quality, And Fitness In Chinook Salmon, Madison A. Sturba
Electronic Theses and Dissertations
Assessing the impact of environmental challenges on maternal state and breeding success is important for predicting how migratory Pacific salmon populations will respond to an increasingly stressful world. The overall goal of my thesis was to examine fine-scale senescent changes in female Chinook salmon over time, whether these changes impacted ovulation and egg quality, and whether exposure to an environmental challenge (low water) during senescence subsequently provoked even stronger state-dependent responses to ultimately impact female longevity and egg survival. Following an experimental decrease in water availability, I quantified changes in physical, physiological, and reproductive maternal state, then linked these changes …
Evaluating The Appropriateness Of Retail Providers’ Selections Of Office Ergonomic Products Based On Customer Orders And Inquiries, Victoria Brunet
Evaluating The Appropriateness Of Retail Providers’ Selections Of Office Ergonomic Products Based On Customer Orders And Inquiries, Victoria Brunet
Electronic Theses and Dissertations
Product providers are individuals working for companies who are responsible for aiding and selecting office ergonomic products for clients and are key players in the product purchasing stage of the Office Workstation Assessment, Recommendation, Purchasing and Implementation (OWARPI) process. Despite the importance of their role to ensure proper products are selected, there is no existing research on product providers. The objective of this two-part study was to evaluate how companies within the product provider sector (both ergonomic and non-ergonomic) in Ontario, Canada performed when recommending products. Each company was presented with 15 vignettes via an alias-blocked procedure. Performance was evaluated …
The Role Of The Nkr-P1b:Clr-B Inhibitory Axis In Nk Cell-Mediated Tumour Immunosurveillance, Abd El Aziz Hendy
The Role Of The Nkr-P1b:Clr-B Inhibitory Axis In Nk Cell-Mediated Tumour Immunosurveillance, Abd El Aziz Hendy
Electronic Theses and Dissertations
Natural killer (NK) cells are lymphocytes of the innate immune system which do not require prior priming to target infected or altered-self cells, such as tumour cells. The basic functions of NK cells include cytotoxicity and cytokine production. These cells possess numerous activating and inhibitory receptors which regulate their function based on a signalling balance. In mice, NK cells possess NKR-P1B inhibitory receptors which recognize the C-type lectin-related protein-b (Clr-b) ligand. This ligand is present on healthy self cells and may be used by cancer cells to evade NK cell effector functions. The disruption of the NKR-P1B:Clr-b axis has been …
Analysis Of The Sphingolipid Profile In Regenerating Skeletal Muscle Of A Murine Model Of Type 1 Diabetes Mellitus, Jacob Oulette
Analysis Of The Sphingolipid Profile In Regenerating Skeletal Muscle Of A Murine Model Of Type 1 Diabetes Mellitus, Jacob Oulette
Electronic Theses and Dissertations
Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease that destroys the pancreatic β-cells. Poor skeletal muscle regeneration and atrophy are associated with T1DM, termed diabetic myopathy, which includes an accumulation of muscle lipids. Sphingolipids are a class of lipids that display powerful cellular effects and are implicated in roles in skeletal muscle regeneration and diabetic myopathy. However, sphingolipids have yet to be quantified in regenerating skeletal muscle of animal models of T1DM. This project aimed to examine the sphingolipid profile of wild type (WT) and Ins2Akita+/- (Akita) mice following cardiotoxin(CTX)-induced injury. 22 WT and 20 Akita mice received an …
A Novel Role For Frequenin In Drosophila Melanogaster Courtship, Renada Hana
A Novel Role For Frequenin In Drosophila Melanogaster Courtship, Renada Hana
Electronic Theses and Dissertations
The Drosophila calcium-binding proteins Frequenin1 (Frq1) and Frequenin2 (Frq2), and their mammalian homologue Neuronal Calcium Sensor-1 (NCS-1), have been extensively reported to regulate several aspects of synaptic function. Although Frq/NCS-1 is well studied at the molecular level and is expected to regulate normal neurological development, as it is implicated in several diseases, less is known about its role in behaviour. Thus, in the present study, I aimed to determine if the role of Frq1 and Frq2 in synaptic function leads to a role in the complex Drosophila behaviour, courtship. I tested naïve courtship levels of two frq null mutants, frq …
The Effects Of A 12-Week, Virtual, At-Home Upper Limb Training Program For Stroke Survivors On Falls Self-Efficacy And Physical Functioning, Amanda Tetzlaff
The Effects Of A 12-Week, Virtual, At-Home Upper Limb Training Program For Stroke Survivors On Falls Self-Efficacy And Physical Functioning, Amanda Tetzlaff
Electronic Theses and Dissertations
Chronic health conditions and sedentary behaviour are major public health concerns among older adults. The relationship between falls and upper limb strength becomes increasingly apparent among stroke survivors. In addition to helping prevent a fall from occurring, the upper limbs play a significant role in the performing activities of daily living and other meaningful tasks. However, fall prevention and stroke research focused on exercise and rehabilitation has primarily focused on lower-limb impairments. Thus, the objective of this study was to determine if a 12-week upper limb, virtual, at-home exercise intervention had an effect on falls self-efficacy and physical functioning on …
An Integrated Approach To Understanding Anthonomus Eugenii Cano (Coleoptera: Curculionidae): An Exotic Pest Of Greenhouse And Field Pepper Crops, Diana Catalina Fernandez
An Integrated Approach To Understanding Anthonomus Eugenii Cano (Coleoptera: Curculionidae): An Exotic Pest Of Greenhouse And Field Pepper Crops, Diana Catalina Fernandez
Electronic Theses and Dissertations
Anthonomus eugenii, the pepper weevil is an important pest of cultivated pepper plants (Capsicum spp.). The weevil is originally from Mexico, but it is present in Central America, the Caribbean, and southern United States. Additionally, it was present and eradicated in the Netherlands, Italy, and western Canada in British Columbia. However, sporadic outbreaks occur during the pepper growing season in southern Ontario, which has prompted further investigation of its biology and management. My dissertation investigates the genetics, physiology and ecology of the pepper weevil and its implications for prevention, management, and potential establishment in southern Ontario. I investigated …
An Enhancement To Cnn Approach With Synthesized Image Data For Disease Subtype Classification, Narider Pal Singh
An Enhancement To Cnn Approach With Synthesized Image Data For Disease Subtype Classification, Narider Pal Singh
Electronic Theses and Dissertations
The introduction of genetic testing has profoundly enhanced the prospects of early detection of diseases and techniques to suggest precision medicines. The subtyping of critical diseases has proven to be an essential part of the development of individualized therapies and has led to deeper insights into the heterogeneity of the disease. Studies suggest that variants in particular genes have significant effects on certain types of immune system cells and are also involved in the risk of certain critical illnesses like cancer. By analyzing the genetic sequence of a patient, disease types and subtypes can be predicted. Recent research work has …
Regulation Of The Ribosome Biogenesis Factor Hyvh1 By Src-Mediated Phosphorylation, Ashley Anne Dadalt
Regulation Of The Ribosome Biogenesis Factor Hyvh1 By Src-Mediated Phosphorylation, Ashley Anne Dadalt
Electronic Theses and Dissertations
The protein tyrosine phosphatase (PTP) superfamily is a major segment of the signal transduction landscape, responsible for regulating the biomolecular phosphorylation status of the cell. Diverse PTP subclasses exist, some of which are understudied and whose cellular functions are not yet fully elucidated. YVH1, an atypical PTP of the dual-specificity phosphatase (DUSP) subclass, is a pleiotropic enzyme with no known substrate. Human YVH1 (hYVH1) protects cells from cellular stressors, including heat shock and oxidative stress, regulates the cell cycle, disassembles stress granules, and acts as 60S ribosome biogenesis factor. Additionally, heat shock protein 70 (Hsp70) has been found to be …
Bioacoustic Studies Of Population Size And Microdialects In An Island-Living Savannah Sparrow Population, Abby Lynn Jill Hensel
Bioacoustic Studies Of Population Size And Microdialects In An Island-Living Savannah Sparrow Population, Abby Lynn Jill Hensel
Electronic Theses and Dissertations
Bioacoustic monitoring provides an innovative technique for studying the behaviour and ecology of wild birds. In this thesis I use bioacoustic monitoring as a tool for studying Savannah Sparrows (Passerculus sandwichensis). In my first data chapter, I tested the accuracy of passive acoustic monitoring in estimating population size and annual survival in an island population of Savannah Sparrows. Six years of data reveal that passive acoustic monitoring with autonomous recorders provides accurate underestimates of population size and annual survival. I found that passive acoustic monitoring estimated population size with 74% accuracy, with higher accuracy in low density years. I also …
Allowing The Experiences Of Older Adults To Be Heard: Interpreting Senior Centre Accessibility, Fallon Mitchell
Allowing The Experiences Of Older Adults To Be Heard: Interpreting Senior Centre Accessibility, Fallon Mitchell
Electronic Theses and Dissertations
Senior centres aim to support and improve the health of older adults by offering a wide variety ofservices and activities tailored to their needs, yet there is little known about accessibility of senior centres. Inaccessible environments can negatively impact participation and health potentially leading to increased sedentary behaviour and morbidity. This study explores the accessibility experiences of older adults through a case study of a senior centre in Southwestern Ontario. This study utilizes a hermeneutic phenomenological approach to ascertain a deeper understanding of the participants’ lived experiences. Six older adult members (m = 2, f = 4; Mage = 72 …
Does It Take A Community To Save A Species? Examining The Use Of Community Interactions To Restore Unionid Species At Risk, Roland Adriaan Eveleens
Does It Take A Community To Save A Species? Examining The Use Of Community Interactions To Restore Unionid Species At Risk, Roland Adriaan Eveleens
Electronic Theses and Dissertations
The conservation and restoration of freshwater ecosystems are complex. Knowledge from community ecology, conservation biology, and restoration ecology was integrated to interrogate the role of species interactions involving freshwater mussels (order Unionida) as keystone species. Freshwater mussels require host fish and provide ecosystem functions for other species throughout aquatic and riparian ecosystems, yet conservation efforts remain focused on focal mussel species or host fish associations. My thesis explored species co-occurrences within mussel and benthic macroinvertebrate community assemblages, and systematically reviewed the published literature to assess the breadth and reported effectiveness of mussel restoration. Community analyses confirmed species co-occurrences across environmental …
The Development And Application Of Targeted Edna Metabarcoding For Monitoring Freshwater And Marine Ais, Yueyang Wu
The Development And Application Of Targeted Edna Metabarcoding For Monitoring Freshwater And Marine Ais, Yueyang Wu
Electronic Theses and Dissertations
Species invasions are of critical concern due to their significant impacts on ecosystems and social economies, of which aquatic invasive species (AIS) often pose significant challenges in their control and management, notably because of difficulties in early detection. Environmental DNA (eDNA) provides a promising tool in advancing the detection of newly introduced aquatic organisms because of its high sensitivity and ease of use compared to traditional capture-based methods. Although eDNA-based methods are increasingly used worldwide, especially in aquatic ecosystems, most studies focus on a limited number of target species despite a pressing need for broad taxonomic monitoring for conservation and …
Parasites And Sexual Selection In A Sexually Dichromatic Toad, Nicole Erin Shangi
Parasites And Sexual Selection In A Sexually Dichromatic Toad, Nicole Erin Shangi
Electronic Theses and Dissertations
Parasitism is among the most common and successful life history strategies on Earth, leading to constant coevolution between parasites and hosts. Parasites continuously pressure hosts to evolve more effective parasite resistance, fueling interest in the relationships between expression of sexually selected host ornamentation and parasite resistance. By studying parasite-mediated sexual selection we gain unique insights into the evolution of animal traits. In this thesis, I attempt to further our understanding of a sexually dichromatic neotropical anuran by studying its parasites in the context of sexual selection. Firstly, in the General Introduction (Chapter 1), I reviewed important background information key to …
A Program Evaluation Of Nutrition-Based Educational Modules Designed For The University Of Windsor Lancers Varsity Athletics, Justine Van Herk
A Program Evaluation Of Nutrition-Based Educational Modules Designed For The University Of Windsor Lancers Varsity Athletics, Justine Van Herk
Electronic Theses and Dissertations
The purpose of this program evaluation was to develop nutrition-based educational modules for the coaches and student-athletes at the University of Windsor and to investigate their effectiveness, usefulness, and applicability. The nutrition-based educational modules were a collaborative effort between the Community Health, Environment, and Wellness (CHEW) lab and the Centre for Human Performance and Health (CHPH). Eight teams voluntarily participated in the 6-week implementation period with the nutrition-based educational modules. Following this implementation period, nine participants (n = 2 coaches, n = 7 student-athletes) volunteered to provide feedback during one-on-one semi-structured virtual interviews. The interview guide was divided into …
The Effects Of Probiotic Therapy On Stress Coping Styles Of Triploid Juvenile Farmed Chinook Salmon, Oncorhynchus Tshawytscha, Brendyn M. St. Louis
The Effects Of Probiotic Therapy On Stress Coping Styles Of Triploid Juvenile Farmed Chinook Salmon, Oncorhynchus Tshawytscha, Brendyn M. St. Louis
Electronic Theses and Dissertations
Triploid salmon – fish with three sets of chromosomes – are regularly used in aquaculture as they are functionally sterile and therefore avoid the decline in flesh quality associated with sexual maturation. However, triploid fish exhibit many immune, behavioural, and physiological drawbacks which reduce their condition and survival in aquaculture environments. My research examines the effects of probiotic treatment to promote behavioural and stress-related (termed ‘coping styles’) traits more suited for aquaculture environments in triploid fish with the ultimate goal of increasing fish yield. In this study, Chinook salmon (Oncorhynchus tshawytscha) crosses were developed in a 3x3 and 3x2 design, …
Hla Blockers For Potentially Treating Rheumatoid Arthritis, Samaneh Mehri
Hla Blockers For Potentially Treating Rheumatoid Arthritis, Samaneh Mehri
Electronic Theses and Dissertations
Autoimmune diseases occurs when the immune system recognize self antigens in the body as foreign invaders leads to dysfunction of tissue. RA is an autoimmune disease, caused by improper recognition of self-peptides, particularly human cartilage glycoprotein and type II collagen, by specific human leukocyte antigen (HLA) receptors. Normally T-cell specific for these peptides are destroyed in the thymus before they are released, preventing autoimmunity. However, certain post-translational modifications, especially citrullination, can lead to “self-peptide” recognition by non-self T cells: in the case of RA, one HLA protein (DRB*0401), out of about 1700 possible ones, is responsible for 65% of RA …
Ergonomic Evaluation Of Percentile Height Differences During Automorive Assembly Tasks – A Focus On Joint Angle Kinematics, Joe Kagumba
Electronic Theses and Dissertations
The purpose of this study was to assess the effects of anthropometric height on movement variability during seven simulated automotive assembly tasks. Twenty participants completed seven simulated automotive assembly tasks commonly found in industry. The 20 participants were evenly distributed into one of four groups based on their height. For each group, and during each task, the following seven time-series joint angle profiles were assessed: Elbow Flexion/Extension (Flex/Ext), Shoulder Abduction/Adduction (Abd/Add), Shoulder Forward/Backwards movement (For/Back), Trunk Flex/Ext, Trunk Lateral bending (Lat), Hip Flex/Ext and Knee Flex/Ext. To compare between groups, Statistical Parametric Mapping (SPM) was used to assess group differences …
The Function And Evolution Of Wood-Warbler Flight Calls (Parulidae), Zach G. Gayk
The Function And Evolution Of Wood-Warbler Flight Calls (Parulidae), Zach G. Gayk
Electronic Theses and Dissertations
Animals produce vocalizations to communicate with territorial rivals, to communicate with potential mates, to alert others of predators, or to stay in contact with other animals. To date, little research has focused on the vocalizations that animals use to communicate during migration. Many birds produce flight calls, which are short calls given by migratory birds on the wing. The function of flight calls is poorly understood but they are thought to help migrants maintain contact with other individuals during movements between breeding grounds and wintering grounds. Across four data chapters in my dissertation, I investigated the function and evolution of …
The Effects Of Acid Rain Mitigation Efforts On The Behaviour-Dependent Movement Of Migrating Atlantic Salmon (Salmo Salar, L.) Smolts, Omar Salem Taboun
The Effects Of Acid Rain Mitigation Efforts On The Behaviour-Dependent Movement Of Migrating Atlantic Salmon (Salmo Salar, L.) Smolts, Omar Salem Taboun
Electronic Theses and Dissertations
Acidification has led to changes in the chemistry of fresh waters and has impacted the survival of Atlantic Salmon (Salmo salar), an endangered anadromous fish species. Liming, which has been implemented to restore freshwater ecosystems, has been demonstrated to restore a suitable pH for Atlantic Salmon, however, it remained unknown to what extent liming can restore the underlying behavioural traits and migration behaviour of smolts. We captured 116 smolts from two freshwater river treatments in Nova Scotia, Canada: acidified Little River (n=17) and lime-treated West River (n=99). We performed stream-side behavioural assays and discerned five behavioural metrics: (1) …
A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba Thomas Alexander
A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba Thomas Alexander
Electronic Theses and Dissertations
In this thesis, we are interested in finding the best drugs that can be repurposed for the disease and able to find the adverse effects such drugs that are FDA-Approved. Developing an effective drug can be a time-consuming and expensive crucible method. Network-based machine learning methods are used for predicting a given drug for A that can be used for B. It aims at finding new indications for already existing drugs and therefore increases the available therapeutic choices at a fraction of the cost of new drug development. The perturbation gene expression data corresponding to the MCF7 cell line was …
Exploring Teacher Perceptions Of Teaching Strategies For Fundamental Movement Skills In Primary Physical Education Programs, Danielle Salters
Exploring Teacher Perceptions Of Teaching Strategies For Fundamental Movement Skills In Primary Physical Education Programs, Danielle Salters
Electronic Theses and Dissertations
Physical education (PE) programs are uniquely situated to promote the development of motor skills during childhood. When children do not receive appropriate instructions during motor skill development, they are likely to experience motor delays. Nevertheless, the relationship between Fundamental Movement Skills (FMS) and teaching styles in PE has remained relatively unexplored in previous research. The present study explored teacher perceptions of FMS through a mixed-methods approach. Participants were a mix of preservice, specialist, and general primary school teachers with varying levels of PE experience. Surveys were used to assess self-reported use of the spectrum of teaching styles among PE teachers. …
Examining The Links Between Environmental Variation, Foraging Behaviour And Foraging Success In An Arctic Seabird, Alyssa Eby
Electronic Theses and Dissertations
Arctic regions are experiencing increasing variability in inter-annual sea ice dynamics ultimately impacting marine Arctic ecosystems. Arctic-breeding seabirds, such as thick-billed murres (Uria lomvia) are thus likely to be negatively impacted by fluctuating environmental conditions through its influence on prey availability. Additional extrinsic factors (colony size and chick demand) and intrinsic factors (sex) are also likely to impact foraging behaviour and success of murres in combination with environmental conditions. First, we tested the effect of colony size on colony sensitivity to environmental change at two low Arctic colonies of varying sizes, Coats Island, Nunavut and Digges Island, Nunavut …