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Articles 1 - 30 of 95
Full-Text Articles in Life Sciences
Sharing The Salt Bowl: Counterion Identity Drives N-Alkyl Resorcinarene Affinity For Pyrophosphate In Water, Kwaku Twum, Seyed Iraj Sadraei, Jordan Feder, S. Maryamdokht Taimoory, Kari Rissanen, John F. Trant, Ngong Kodiah Beyeh
Sharing The Salt Bowl: Counterion Identity Drives N-Alkyl Resorcinarene Affinity For Pyrophosphate In Water, Kwaku Twum, Seyed Iraj Sadraei, Jordan Feder, S. Maryamdokht Taimoory, Kari Rissanen, John F. Trant, Ngong Kodiah Beyeh
Chemistry and Biochemistry Publications
N-Alkyl ammonium resorcinarene chloride receptors, NARX4, have been shown to act as high-sensitivity detectors of pyrophosphate (PPi), a biomarker of disease, in aqueous media through the chloride-to-PPi exchange [NAR(Cl)4 to NARPPi]. The nature of the anion of the macrocyclic NARX4 (X = Cl−, Br−, triflate OTf−) receptor greatly influences the PPi-affinity in aqueous media. The binding affinity for [NAR (Cl)4] is 3.61 × 105 M−1, while the NAR (Br)4 and NAR (OTf)4 show stronger binding of 5.30 × 105 M−1, and 6.10 × 105 M−1, respectively. The effects of upper rim ammonium cation, –N+H2R substituents (R = 3-hydroxypropyl, cyclohexyl, …
Reaction Of Alkynyl- And Alkenyltrifluoroborates With Propargyldicobalt Cations: Alkynylation, Alkenylation, And Cyclopropanation Product Pathways, Brent St Onge, S. Maryamdokht Taimoory, Jeffrey Battersby, John F. Trant, James R. Green
Reaction Of Alkynyl- And Alkenyltrifluoroborates With Propargyldicobalt Cations: Alkynylation, Alkenylation, And Cyclopropanation Product Pathways, Brent St Onge, S. Maryamdokht Taimoory, Jeffrey Battersby, John F. Trant, James R. Green
Chemistry and Biochemistry Publications
The Lewis acid-mediated Nicholas reactions of propargyl acetate–Co2(CO)6 complexes with a series of potassium alkynyltrifluoroborates and potassium alkenyltrifluoroborates are described. Alkynyltrifluoroborates directly alkynylate the intermediate propargyldicobalt cations. In contrast, alkenyltrifluoroborates proceed through one of the three modes of dominant reactivity: C-2-substituted alkenyltrifluorobrates directly alkenylate, predominantly with the retention of stereochemistry. C-1-substituted alkenyltrifluoroborates alkenylate at C-2. Potassium vinyltrifluoroborate incorporates a cyclopropane at the site propargyl to alkynedicobalt. Computational analysis of these systems explains the differential modes of reactivity of alkenyltrifluoroborates and outlines the probable mechanisms for the formation of each product.
Protocol For Fabricating Electroless Nickel Immersion Gold Strain Sensors On Nitrile Butadiene Rubber Gloves For Wearable Electronics, Sara S. Mechael, Yunyun Wu, Yiting Chen, Tricia Breen Carmichael
Protocol For Fabricating Electroless Nickel Immersion Gold Strain Sensors On Nitrile Butadiene Rubber Gloves For Wearable Electronics, Sara S. Mechael, Yunyun Wu, Yiting Chen, Tricia Breen Carmichael
Chemistry and Biochemistry Publications
This protocol describes the fabrication of patterned conductive gold films on nitrile butadiene rubber (NBR) gloves for wearable strain sensors using electroless nickel immersion gold (ENIG) plating, a solution-based metallization technique. The resulting NBR/ENIG films are strain sensitive; resistance measurements of a patterned sensing array can be used to map human hand motions. This protocol also describes challenges related to the ENIG process and troubleshooting steps to achieve conformal gold films for strain sensing over a large working range. For complete details on the use and execution of this protocol, please refer to Mechael et al. (2021).
Early Life Neonicotinoid Exposure Results In Proximal Benefits And Ultimate Carryover Effects, Thomas Zgirski, Pierre Legagneux, Olivier Chastel, Lyette Regimbald, Louise Prouteau, Audrey Le Pogam, Hélène Budzinski, Oliver P. Love, François Vézina
Early Life Neonicotinoid Exposure Results In Proximal Benefits And Ultimate Carryover Effects, Thomas Zgirski, Pierre Legagneux, Olivier Chastel, Lyette Regimbald, Louise Prouteau, Audrey Le Pogam, Hélène Budzinski, Oliver P. Love, François Vézina
Great Lakes Institute for Environmental Research Publications
Neonicotinoids are insecticides widely used as seed treatments that appear to have multiple negative effects on birds at a diversity of biological scales. Adult birds exposed to a low dose of imidacloprid, one of the most commonly used neonicotinoids, presented reduced fat stores, delayed migration and potentially altered orientation. However, little is known on the effect of imidacloprid on birds growth rate despite studies that have documented disruptive effects of low imidacloprid doses on thyroid gland communication. We performed a 2 × 2 factorial design experiment in Zebra finches, in which nestling birds were exposed to a very low dose …
Herd Immunity Drives The Epidemic Fadeout Of Avian Cholera In Arctic-Nesting Seabirds, Jacintha G.B. Van Dijk, Samuel A. Iverson, H. Grant Gilchrist, N. Jane Harms, Holly L. Hennin, Oliver P. Love, E. Isabel Buttler, Stephanie Lesceu, Jeffrey T. Foster, Mark R. Forbes, Catherine Soos
Herd Immunity Drives The Epidemic Fadeout Of Avian Cholera In Arctic-Nesting Seabirds, Jacintha G.B. Van Dijk, Samuel A. Iverson, H. Grant Gilchrist, N. Jane Harms, Holly L. Hennin, Oliver P. Love, E. Isabel Buttler, Stephanie Lesceu, Jeffrey T. Foster, Mark R. Forbes, Catherine Soos
Great Lakes Institute for Environmental Research Publications
Avian cholera, caused by the bacterium Pasteurella multocida, is a common and important infectious disease of wild birds in North America. Between 2005 and 2012, avian cholera caused annual mortality of widely varying magnitudes in Northern common eiders (Somateria mollissima borealis) breeding at the largest colony in the Canadian Arctic, Mitivik Island, Nunavut. Although herd immunity, in which a large proportion of the population acquires immunity to the disease, has been suggested to play a role in epidemic fadeout, immunological studies exploring this hypothesis have been missing. We investigated the role of three potential drivers of fadeout of avian cholera …
Synergistic Broad-Spectrum Antibacterial Activity Of Hypoxis Hemerocallidea-Derived Silver Nanoparticles And Streptomycin Against Respiratory Pathobionts, Oluwole S. Aremu, T. Qwebani-Ogunleye, Lebogang Katata-Seru, Zimbili Mkhize, John F. Trant
Synergistic Broad-Spectrum Antibacterial Activity Of Hypoxis Hemerocallidea-Derived Silver Nanoparticles And Streptomycin Against Respiratory Pathobionts, Oluwole S. Aremu, T. Qwebani-Ogunleye, Lebogang Katata-Seru, Zimbili Mkhize, John F. Trant
Chemistry and Biochemistry Publications
Respiratory tract infections arise due to the introduction of microbes into the airway, disrupting the normal, healthy, complex interdependent microbiome. The selective disruption of this community can be either beneficial or dangerous. Nanoparticles are a potential tool for modifying this population. Coated silver nanoparticles (AgNPs) were synthesized using ethanolic extracts of Hypoxis hemerocallidea (EEHH), a Southern African plant used extensively in traditional medicine and the source of many bioactive secondary metabolites. The room temperature reaction between silver nitrate and EEHH forms largely spherical AgNPs with an average diameter of 6–20 nm. These nanoparticles show similar levels of antibacterial activity as …
New Isolate From Salvinia Molesta With Antioxidant And Urease Inhibitory Activity, Nadra Naheed, Saima Maher, Farooq Saleem, Ajmal Khan, Abdul Wadood, Saima Rasheed, M. Iqbal Choudhary, Matheus Froeyen, Iskandar Abdullah, Muhammad Usman Mirza, John F. Trant, Sarfraz Ahmad
New Isolate From Salvinia Molesta With Antioxidant And Urease Inhibitory Activity, Nadra Naheed, Saima Maher, Farooq Saleem, Ajmal Khan, Abdul Wadood, Saima Rasheed, M. Iqbal Choudhary, Matheus Froeyen, Iskandar Abdullah, Muhammad Usman Mirza, John F. Trant, Sarfraz Ahmad
Chemistry and Biochemistry Publications
Urease plays a significant role in the pathogenesis of urolithiasis pyelonephritis, urinary catheter encrustation, hepatic coma, hepatic encephalopathy, and peptic acid duodenal ulcers. Salvinia molesta was explored to identify new bioactive compounds with particular emphasis on urease inhibitors. The aqueous methanol extract was fractionated using solvents of increasing polarity. A series of column chromatography and later HPLC were performed on butanol extract. The structures of the resulting pure compounds were resolved using NMR (1D and 2D), infrared, and mass spectroscopy. The novel isolate was evaluated for antioxidant activity (using DPPH, superoxide anion radical scavenging, oxidative burst, and Fe+2 chelation assays), …
Ecoacoustic Monitoring Of Lake Sturgeon (Acipenser Fulvescens) Spawning And Its Relation To Anthropogenic Noise, Dennis M. Higgs, Riley K. Beach
Ecoacoustic Monitoring Of Lake Sturgeon (Acipenser Fulvescens) Spawning And Its Relation To Anthropogenic Noise, Dennis M. Higgs, Riley K. Beach
Integrative Biology Publications
Lake sturgeon (Acipenser fulvescens) are endangered in the Laurentian Great Lakes with increasing binational efforts to establish spawning grounds to aid restoration. While SCUBA surveys can document spawning activity, these are labour-intensive and may disrupt spawning. We used passive acoustic monitoring to quantify spawning sounds of lake sturgeon as a first step to developing remote sensing of sturgeon spawning grounds. Acipenser sp. are known to make a variety of sounds including, “thunders” (aka drums), which have been documented in A. fulvescens during spawning. We quantified drums from a known spawning bed. We recorded 5 different potential sturgeon sounds but only …
The Role Of The Circadian Clock In The Intestinal Epithelium During Health, Regeneration, And Tumourigenesis, Kyle Stokes
The Role Of The Circadian Clock In The Intestinal Epithelium During Health, Regeneration, And Tumourigenesis, Kyle Stokes
Electronic Theses and Dissertations
The Earth’s axial rotation subjects its surface to constant periods of light and dark, this is known as photoperiod. Many organisms have adapted their physiology in accordance with this environmental constant by generating 24h rhythms in their physiological functions; these are known as circadian rhythms. Circadian rhythms are controlled by an endogenous time-keeping mechanism known as the circadian clock. Over 40% of the genome in mice and over 80% of the genome in primates has been shown to have 24h rhythms in transcription. The disruption of circadian rhythms through shiftwork, jetlag, or exposure to light at night is associated with …
From Fat To Bilayers: Understanding Where And How Vitamin E Works, Jeffrey Atkinson, Drew Marquardt, Mitchell Dipasquale, Thad Harroun
From Fat To Bilayers: Understanding Where And How Vitamin E Works, Jeffrey Atkinson, Drew Marquardt, Mitchell Dipasquale, Thad Harroun
Chemistry and Biochemistry Publications
Vitamin E was one of the last fat-soluble vitamins to be discovered. We provide here an historical review of the discovery and the increasingly more detailed understanding of the role of α-tocopherol both as an antioxidant and as a structural component of phospholipid bilayer membranes. Despite the detailed descriptions now available of the orientation, location, and dynamics of α-tocopherol in lipid bilayers, there are still gaps in our knowledge of the effect of α-tocopherol and its potential receptors than control gene transcription.
Spatio-Temporal Variability In White Shark (Carcharodon Carcharias) Movement Ecology During Residency And Migration Phases In The Western North Atlantic, Bryan R. Franks, John P. Tyminski, Nigel E. Hussey, Camrin D. Braun, Alisa L. Newton, Simon R. Thorrold, George C. Fischer, Brett Mcbride, Robert E. Hueter
Spatio-Temporal Variability In White Shark (Carcharodon Carcharias) Movement Ecology During Residency And Migration Phases In The Western North Atlantic, Bryan R. Franks, John P. Tyminski, Nigel E. Hussey, Camrin D. Braun, Alisa L. Newton, Simon R. Thorrold, George C. Fischer, Brett Mcbride, Robert E. Hueter
Integrative Biology Publications
Understanding how mobile, marine predators use three-dimensional space over time is central to inform management and conservation actions. Combining tracking technologies can yield powerful datasets over multiple spatio-temporal scales to provide critical information for these purposes. For the white shark (Carcharodon carcharias), detailed movement and migration information over ontogeny, including inter- and intra-annual variation in timing of movement phases, is largely unknown in the western North Atlantic (WNA), a relatively understudied area for this species. To address this need, we tracked 48 large juvenile to adult white sharks between 2012 and 2020, using a combination of satellite-linked and acoustic telemetry. …
Efficient And Reproducible Synthesis Of An Fmoc-Protected Tn Antigen, Sabrina M. Piazza, Michael R. Reynolds, Jonathan Chiaramonte, Peihan Xu, Fabiola A. Chapa-Villarreal, John F. Trant
Efficient And Reproducible Synthesis Of An Fmoc-Protected Tn Antigen, Sabrina M. Piazza, Michael R. Reynolds, Jonathan Chiaramonte, Peihan Xu, Fabiola A. Chapa-Villarreal, John F. Trant
Chemistry and Biochemistry Publications
This concise total synthesis of the Thomsen-Nouveau (Tn) glycoconjugate was accomplished using a palladium-catalyzed coupling between the glycosyl donor and Fmoc-protected serine acceptor. This is, to the best of our knowledge, the shortest synthesis reported from galactose for preparing this essential building block for large-scale solid phase peptide synthesis.
Drought At A Coastal Wetland Affects Refuelling And Migration Strategies Of Shorebirds, Alexandra M. Anderson, Christian Friis, Cheri L. Gratto-Trevor, Christopher M. Harris, Oliver P. Love, R. I.Guy Morrison, Sean W.J. Prosser, Erica Nol, Paul A. Smith
Drought At A Coastal Wetland Affects Refuelling And Migration Strategies Of Shorebirds, Alexandra M. Anderson, Christian Friis, Cheri L. Gratto-Trevor, Christopher M. Harris, Oliver P. Love, R. I.Guy Morrison, Sean W.J. Prosser, Erica Nol, Paul A. Smith
Great Lakes Institute for Environmental Research Publications
Droughts can affect invertebrate communities in wetlands, which can have bottom-up effects on the condition and survival of top predators. Shorebirds, key predators at coastal wetlands, have experienced widespread population declines and could be negatively affected by droughts. We explored, in detail, the effects of drought on multiple aspects of shorebird stopover and migration ecology by contrasting a year with average wet/dry conditions (2016) with a year with moderate drought (2017) at a major subarctic stopover site on southbound migration. We also examined the effects of drought on shorebird body mass during stopover across 14 years (historical: 1974–1982 and present-day: …
A Calorimetric, Volumetric And Combined Sans And Saxs Study Of Hybrid Siloxane Phosphocholine Bilayers, Mark B. Frampton, Doruntina Yakoub, John Katsaras, Paul M. Zelisko, Drew Marquardt
A Calorimetric, Volumetric And Combined Sans And Saxs Study Of Hybrid Siloxane Phosphocholine Bilayers, Mark B. Frampton, Doruntina Yakoub, John Katsaras, Paul M. Zelisko, Drew Marquardt
Chemistry and Biochemistry Publications
Siloxanes are molecules used extensively in commercial, industrial, and biomedical applications. The inclusion of short siloxane chains into phospholipids results in interesting physical properties, including the ability to form low polydispersity unilamellar vesicles. As such, hybrid siloxane phosphocholines (SiPCs) have been examined as a potential platform for the delivery of therapeutic agents. Using small angle X-ray and neutron scattering, vibrating tube densitometry, and differential scanning calorimetry, we studied four hybrid SiPCs bilayers. Lipid volume measurements for the different SiPCs compared well with those previously determined for polyunsaturated PCs. Furthermore, the different SiPC's membrane thicknesses increased monotonically with temperature and, for …
Accident Experiences And Reporting Practices In Canadian Chemistry And Biochemistry Labs: A Pilot Investigation, Dana Ménard, John F. Trant
Accident Experiences And Reporting Practices In Canadian Chemistry And Biochemistry Labs: A Pilot Investigation, Dana Ménard, John F. Trant
Chemistry and Biochemistry Publications
Accidents in chemistry and biochemistry laboratories are a regular occurrence and have been associated with injuries, property damage, and deaths. However, despite a high prevalence rate of accident involvement reported in previous investigations of academic lab personnel (approximately 30%), little is known about the context in which academic lab accidents occur. Previous findings also suggest a high degree of accident underreporting (25–40%), but again, little is known about this phenomenon. Pilot data was gathered from a convenience sample of 104 students and postdoctoral fellows in chemistry-related fields through an online survey. Results showed a high level of accident involvement (56.7%); …
Timing Of Breeding Site Availability Across The North-American Arctic Partly Determines Spring Migration Schedule In A Long-Distance Neotropical Migrant, Jean François Lamarre, Gilles Gauthier, Richard B. Lanctot, Sarah T. Saalfeld, Oliver P. Love, Eric Reed, Oscar W. Johnson, Joe Liebezeit, Rebecca Mcguire, Mike Russell, Erica Nol, Laura Koloski, Felicia Sanders, Laura Mckinnon, Paul A. Smith, Scott A. Flemming, Nicolas Lecomte, Marie Andrée Giroux
Timing Of Breeding Site Availability Across The North-American Arctic Partly Determines Spring Migration Schedule In A Long-Distance Neotropical Migrant, Jean François Lamarre, Gilles Gauthier, Richard B. Lanctot, Sarah T. Saalfeld, Oliver P. Love, Eric Reed, Oscar W. Johnson, Joe Liebezeit, Rebecca Mcguire, Mike Russell, Erica Nol, Laura Koloski, Felicia Sanders, Laura Mckinnon, Paul A. Smith, Scott A. Flemming, Nicolas Lecomte, Marie Andrée Giroux
Great Lakes Institute for Environmental Research Publications
Long-distance migrants are under strong selection to arrive on their breeding grounds at a time that maximizes fitness. Many arctic birds start nesting shortly after snow recedes from their breeding sites and timing of snowmelt can vary substantially over the breeding range of widespread species. We tested the hypothesis that migration schedules of individuals co-occurring at the same non-breeding areas are adapted to average local environmental conditions encountered at their specific and distant Arctic breeding locations. We predicted that timing of breeding site availability (measured here as the average snow-free date) should explain individual variation in departure time from shared …
Fabrication Of An Autonomously Self-Healing Flexible Thin-Film Capacitor By Slot-Die Coating, Susanna Vu, Gnanesh Nagesh, Nastaran Yousefi, John F. Trant, David S.K. Ting, M. Jalal Ahamed, Simon Rondeau-Gagné
Fabrication Of An Autonomously Self-Healing Flexible Thin-Film Capacitor By Slot-Die Coating, Susanna Vu, Gnanesh Nagesh, Nastaran Yousefi, John F. Trant, David S.K. Ting, M. Jalal Ahamed, Simon Rondeau-Gagné
Chemistry and Biochemistry Publications
Flexible pressure sensors with self-healing abilities for wearable electronics are being developed, but generally either lack autonomous self-healing properties or require sophisticated material processing methods. To address this challenge, we developed flexible, low-cost and autonomously self-healing capacitive sensors using a crosslinked poly(dimethylsiloxane) through metal-ligand interactions processed into thin films via slot-die coating. These films have excellent self-healing properties, approximately 1.34 × 105 μm3 per hour at room temperature and 2.87 × 105 μm3 per hour at body temperature (37 °C). Similarly, no significant change in capacitance under bending strain was observed on these flexible thin-films when assembled on poly(ethyleneterephthalate) (PET) …
Environmental Studies Of Cyanobacterial Harmful Algal Blooms Should Include Interactions With The Dynamic Microbiome, Helena L. Pound, Robbie M. Martin, Cody S. Sheik, Morgan M. Steffen, Silvia E. Newell, Gregory J. Dick, R. Michael L. Mckay, George S. Bullerjahn, Steven W. Wilhelm
Environmental Studies Of Cyanobacterial Harmful Algal Blooms Should Include Interactions With The Dynamic Microbiome, Helena L. Pound, Robbie M. Martin, Cody S. Sheik, Morgan M. Steffen, Silvia E. Newell, Gregory J. Dick, R. Michael L. Mckay, George S. Bullerjahn, Steven W. Wilhelm
Great Lakes Institute for Environmental Research Publications
No abstract provided.
Evaluating The Appropriateness Of Retail Providers’ Selections Of Office Ergonomic Products Based On Customer Orders And Inquiries, Victoria Brunet
Evaluating The Appropriateness Of Retail Providers’ Selections Of Office Ergonomic Products Based On Customer Orders And Inquiries, Victoria Brunet
Electronic Theses and Dissertations
Product providers are individuals working for companies who are responsible for aiding and selecting office ergonomic products for clients and are key players in the product purchasing stage of the Office Workstation Assessment, Recommendation, Purchasing and Implementation (OWARPI) process. Despite the importance of their role to ensure proper products are selected, there is no existing research on product providers. The objective of this two-part study was to evaluate how companies within the product provider sector (both ergonomic and non-ergonomic) in Ontario, Canada performed when recommending products. Each company was presented with 15 vignettes via an alias-blocked procedure. Performance was evaluated …
Allowing The Experiences Of Older Adults To Be Heard: Interpreting Senior Centre Accessibility, Fallon Mitchell
Allowing The Experiences Of Older Adults To Be Heard: Interpreting Senior Centre Accessibility, Fallon Mitchell
Electronic Theses and Dissertations
Senior centres aim to support and improve the health of older adults by offering a wide variety ofservices and activities tailored to their needs, yet there is little known about accessibility of senior centres. Inaccessible environments can negatively impact participation and health potentially leading to increased sedentary behaviour and morbidity. This study explores the accessibility experiences of older adults through a case study of a senior centre in Southwestern Ontario. This study utilizes a hermeneutic phenomenological approach to ascertain a deeper understanding of the participants’ lived experiences. Six older adult members (m = 2, f = 4; Mage = 72 …
Parasites And Sexual Selection In A Sexually Dichromatic Toad, Nicole Erin Shangi
Parasites And Sexual Selection In A Sexually Dichromatic Toad, Nicole Erin Shangi
Electronic Theses and Dissertations
Parasitism is among the most common and successful life history strategies on Earth, leading to constant coevolution between parasites and hosts. Parasites continuously pressure hosts to evolve more effective parasite resistance, fueling interest in the relationships between expression of sexually selected host ornamentation and parasite resistance. By studying parasite-mediated sexual selection we gain unique insights into the evolution of animal traits. In this thesis, I attempt to further our understanding of a sexually dichromatic neotropical anuran by studying its parasites in the context of sexual selection. Firstly, in the General Introduction (Chapter 1), I reviewed important background information key to …
A Program Evaluation Of Nutrition-Based Educational Modules Designed For The University Of Windsor Lancers Varsity Athletics, Justine Van Herk
A Program Evaluation Of Nutrition-Based Educational Modules Designed For The University Of Windsor Lancers Varsity Athletics, Justine Van Herk
Electronic Theses and Dissertations
The purpose of this program evaluation was to develop nutrition-based educational modules for the coaches and student-athletes at the University of Windsor and to investigate their effectiveness, usefulness, and applicability. The nutrition-based educational modules were a collaborative effort between the Community Health, Environment, and Wellness (CHEW) lab and the Centre for Human Performance and Health (CHPH). Eight teams voluntarily participated in the 6-week implementation period with the nutrition-based educational modules. Following this implementation period, nine participants (n = 2 coaches, n = 7 student-athletes) volunteered to provide feedback during one-on-one semi-structured virtual interviews. The interview guide was divided into …
The Development And Application Of Targeted Edna Metabarcoding For Monitoring Freshwater And Marine Ais, Yueyang Wu
The Development And Application Of Targeted Edna Metabarcoding For Monitoring Freshwater And Marine Ais, Yueyang Wu
Electronic Theses and Dissertations
Species invasions are of critical concern due to their significant impacts on ecosystems and social economies, of which aquatic invasive species (AIS) often pose significant challenges in their control and management, notably because of difficulties in early detection. Environmental DNA (eDNA) provides a promising tool in advancing the detection of newly introduced aquatic organisms because of its high sensitivity and ease of use compared to traditional capture-based methods. Although eDNA-based methods are increasingly used worldwide, especially in aquatic ecosystems, most studies focus on a limited number of target species despite a pressing need for broad taxonomic monitoring for conservation and …
Physiological State Determinants Of Maternal Cortisol Signaling And Its Impact On Offspring Quality And Fitness, Sydney Currier
Physiological State Determinants Of Maternal Cortisol Signaling And Its Impact On Offspring Quality And Fitness, Sydney Currier
Electronic Theses and Dissertations
Assessing the intergenerational effects of maternal stress is important for predicting how offspring will respond to changing environments. The overall aim of my thesis was to quantify the effects of maternal state on maternally derived egg cortisol and determine whether this variation in egg cortisol impacts Chinook salmon offspring performance and fitness in a sex-specific way. I quantified within-female changes in maternal energetics and reproductive metrics that I linked to egg quality and ultimately embryo survival. I found egg cortisol increases with increasing maternal plasma cortisol, and increases further as plasma cortisol levels rise with each day that eggs are …
Deep Learning Applications In Medical Bioinformatics, Ziad Omar
Deep Learning Applications In Medical Bioinformatics, Ziad Omar
Electronic Theses and Dissertations
After a patient’s breast cancer diagnosis, identifying breast cancer lymph node metastases is one of the most important and critical factor that is directly related to the patient’s survival. The traditional way to examine the existence of cancer cells in the breast lymph nodes is through a lymph node procedure, biopsy. The procedure process is time-consuming for the patient and the provider, costly, and lacks accuracy as not every lymph node is examined. The intent of this study is to develop an artificial neural network (ANNs) that would map genetic biomarkers to breast lymph node classes using ANNs. The neural …
Analysis Of The Sphingolipid Profile In Regenerating Skeletal Muscle Of A Murine Model Of Type 1 Diabetes Mellitus, Jacob Oulette
Analysis Of The Sphingolipid Profile In Regenerating Skeletal Muscle Of A Murine Model Of Type 1 Diabetes Mellitus, Jacob Oulette
Electronic Theses and Dissertations
Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease that destroys the pancreatic β-cells. Poor skeletal muscle regeneration and atrophy are associated with T1DM, termed diabetic myopathy, which includes an accumulation of muscle lipids. Sphingolipids are a class of lipids that display powerful cellular effects and are implicated in roles in skeletal muscle regeneration and diabetic myopathy. However, sphingolipids have yet to be quantified in regenerating skeletal muscle of animal models of T1DM. This project aimed to examine the sphingolipid profile of wild type (WT) and Ins2Akita+/- (Akita) mice following cardiotoxin(CTX)-induced injury. 22 WT and 20 Akita mice received an …
Regulation Of The Ribosome Biogenesis Factor Hyvh1 By Src-Mediated Phosphorylation, Ashley Anne Dadalt
Regulation Of The Ribosome Biogenesis Factor Hyvh1 By Src-Mediated Phosphorylation, Ashley Anne Dadalt
Electronic Theses and Dissertations
The protein tyrosine phosphatase (PTP) superfamily is a major segment of the signal transduction landscape, responsible for regulating the biomolecular phosphorylation status of the cell. Diverse PTP subclasses exist, some of which are understudied and whose cellular functions are not yet fully elucidated. YVH1, an atypical PTP of the dual-specificity phosphatase (DUSP) subclass, is a pleiotropic enzyme with no known substrate. Human YVH1 (hYVH1) protects cells from cellular stressors, including heat shock and oxidative stress, regulates the cell cycle, disassembles stress granules, and acts as 60S ribosome biogenesis factor. Additionally, heat shock protein 70 (Hsp70) has been found to be …
Does It Take A Community To Save A Species? Examining The Use Of Community Interactions To Restore Unionid Species At Risk, Roland Adriaan Eveleens
Does It Take A Community To Save A Species? Examining The Use Of Community Interactions To Restore Unionid Species At Risk, Roland Adriaan Eveleens
Electronic Theses and Dissertations
The conservation and restoration of freshwater ecosystems are complex. Knowledge from community ecology, conservation biology, and restoration ecology was integrated to interrogate the role of species interactions involving freshwater mussels (order Unionida) as keystone species. Freshwater mussels require host fish and provide ecosystem functions for other species throughout aquatic and riparian ecosystems, yet conservation efforts remain focused on focal mussel species or host fish associations. My thesis explored species co-occurrences within mussel and benthic macroinvertebrate community assemblages, and systematically reviewed the published literature to assess the breadth and reported effectiveness of mussel restoration. Community analyses confirmed species co-occurrences across environmental …
The Effects Of Probiotic Therapy On Stress Coping Styles Of Triploid Juvenile Farmed Chinook Salmon, Oncorhynchus Tshawytscha, Brendyn M. St. Louis
The Effects Of Probiotic Therapy On Stress Coping Styles Of Triploid Juvenile Farmed Chinook Salmon, Oncorhynchus Tshawytscha, Brendyn M. St. Louis
Electronic Theses and Dissertations
Triploid salmon – fish with three sets of chromosomes – are regularly used in aquaculture as they are functionally sterile and therefore avoid the decline in flesh quality associated with sexual maturation. However, triploid fish exhibit many immune, behavioural, and physiological drawbacks which reduce their condition and survival in aquaculture environments. My research examines the effects of probiotic treatment to promote behavioural and stress-related (termed ‘coping styles’) traits more suited for aquaculture environments in triploid fish with the ultimate goal of increasing fish yield. In this study, Chinook salmon (Oncorhynchus tshawytscha) crosses were developed in a 3x3 and 3x2 design, …
Hla Blockers For Potentially Treating Rheumatoid Arthritis, Samaneh Mehri
Hla Blockers For Potentially Treating Rheumatoid Arthritis, Samaneh Mehri
Electronic Theses and Dissertations
Autoimmune diseases occurs when the immune system recognize self antigens in the body as foreign invaders leads to dysfunction of tissue. RA is an autoimmune disease, caused by improper recognition of self-peptides, particularly human cartilage glycoprotein and type II collagen, by specific human leukocyte antigen (HLA) receptors. Normally T-cell specific for these peptides are destroyed in the thymus before they are released, preventing autoimmunity. However, certain post-translational modifications, especially citrullination, can lead to “self-peptide” recognition by non-self T cells: in the case of RA, one HLA protein (DRB*0401), out of about 1700 possible ones, is responsible for 65% of RA …