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Full-Text Articles in Life Sciences
Quantifying Limits On Replication, Death, And Quiescence Of Mycobacterium Tuberculosis In Mice, Margaret M. Mcdaniel, Nitin Krishna, Winode G. Handagama, Shigetoshi Eda, Vitaly V. Ganusov
Quantifying Limits On Replication, Death, And Quiescence Of Mycobacterium Tuberculosis In Mice, Margaret M. Mcdaniel, Nitin Krishna, Winode G. Handagama, Shigetoshi Eda, Vitaly V. Ganusov
Microbiology Publications and Other Works
When an individual is exposed to Mycobacterium tuberculosis (Mtb) three outcomes are possible: bacterial clearance, active disease, or latent infection. It is generally believed that most individuals exposed to Mtb become latently infected and carry the mycobacteria for life. How Mtb is maintained during this latent infection remains largely unknown. During an Mtb infection in mice, there is a phase of rapid increase in bacterial numbers in the murine lungs within the first 3 weeks, and then bacterial numbers either stabilize or increase slowly over the period of many months. It has been debated whether the relatively constant numbers of …