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Full-Text Articles in Life Sciences

Supporting Text And Data Analysis Across Campus From The Academic Library, Amy Kirchhoff, Hejin Shin Phd Apr 2024

Supporting Text And Data Analysis Across Campus From The Academic Library, Amy Kirchhoff, Hejin Shin Phd

Digital Initiatives Symposium

The ability to comprehend and communicate with text-based data is essential to future success in academics and employment, as evidenced in a recent survey from Bloomberg Research Services which shows that nearly 97% of survey respondents now use data analytics in their companies and 58% consider data and text mining a business analytics tool (https://www.sas.com/content/dam/SAS/bp_de/doc/studie/ba-st-the-current-state-of-business-analytics-2317022.pdf). This has fueled a substantial growth in text analysis research (involving the use of technology to analyze un- and semi-structured text data for valuable insights, trends, and patterns) across disciplines and a corresponding demand on academic libraries to support text analysis pedagogy and text analysis …


Translation Of: Trembley À Réaumer, Abraham Trembley, Morgan Mclaughlin Jan 2024

Translation Of: Trembley À Réaumer, Abraham Trembley, Morgan Mclaughlin

Biology: Student Scholarship & Creative Works

While examining a jar filled with aquatic plants and animals, Abraham Trembley, a young tutor working for Count William Bentinck in the Netherlands, noticed tiny, green, tube-shaped organisms attached to aquatic plants. Uncertain whether they were plants or animals, he devised a brilliant series of experiments to understand their biology. He observed them contract when disturbed and take steps towards a light, gathering in front of a chevron-shaped opening in a piece of cardboard. Nearly convinced they were animals, he cut one in half expecting to see it die. Instead, it regenerated two perfectly formed bodies from the severed halves. …


Assessing Genomic Literacy In Advanced Practice Nursing Students Before And After An Intervention, Guiselle Palomera May 2023

Assessing Genomic Literacy In Advanced Practice Nursing Students Before And After An Intervention, Guiselle Palomera

Doctor of Nursing Practice Final Manuscripts

Introduction

The purpose of this evidence-based Doctor of Nursing Practice (DNP) project was to examine genetics and genomics literacy in advanced practice nursing students before and after an intervention.

Background

As genomics continue to play an emerging role in healthcare, and advancements are introduced into clinical practice, it is critical that nurses be competent in genetics and genomics concepts. There is a fundamental need to incorporate genomics education into nursing school curriculum. However, studies have shown that the majority of faculty across nursing schools in the United States are ill-equipped to teach genetics and genomics concepts. Furthermore, many interventions to …


Practical Solutions To The Invasion Of Lionfish In Utila, Honduras: Science, Education, Food, And Jewelry, Carolyn Corley May 2023

Practical Solutions To The Invasion Of Lionfish In Utila, Honduras: Science, Education, Food, And Jewelry, Carolyn Corley

Undergraduate Honors Theses

Lionfish (Pterois sp.) are invasive species capable of devastating coral reef ecosystems due to their lack of predators, large appetites, generalist diet, high fecundity, and rapid spawning rates. As lionfish have expanded their distribution across the Caribbean, many conservation groups have taken it upon themselves to systematically remove these predators from environments where they are threatening native species. However, few have involved the community the way I observed while interning with the Whale Shark and Oceanic Research Center in Utila, Honduras. Protecting coral reefs is extremely important, especially in small communities like Utila, where the majority of people’s …


Nursing Education In Complementary Alternative Modalities: A Case Study, Deborah Bird May 2023

Nursing Education In Complementary Alternative Modalities: A Case Study, Deborah Bird

Dissertations

Purpose: The purpose of this embedded case study was to describe the preparation for and utilization of complimentary alternative modality (CAM) interventions by an experienced Doctor of Nursing Practice (DNP) prepared nurse practitioner (NP) working in an outpatient setting.

Background: Given the widespread use of CAM by the American public and the potential complications involved in combining CAM and standard medical care, a lack of educational preparation in CAM interventions by NPs delivering primary care in outpatient health care settings represents both a potential risk and a missed opportunity to provide holistic patient care. Such a lack of knowledge also …


Demystifying The Mind-Body Connection: The Neuroscience Behind How Thoughts Impact Physical Health, Sofia Pantis May 2023

Demystifying The Mind-Body Connection: The Neuroscience Behind How Thoughts Impact Physical Health, Sofia Pantis

Undergraduate Honors Theses

The beliefs, emotions, and experiences that constitute a mindset shape numerous aspects of one’s reality, but in particular, health. Health is defined by not only the physical state of one’s body, but also the content of one’s mind. The integration of the mind and body is often associated with naturopathic medicines or pseudoscience, and thus is usually left out of Western medicinal practices. This review aims to demystify the mind-body connection in health and wellness by introducing it within an empirical, neuroscientific landscape. This research supports the hypothesis that mind over matter rings true even at the biochemical level. Activation …


What Drives Larval Condition For Northern Anchovy (Engraulis Mordax)? Implications For Coastal Pelagic Species Recruitment Fluctuations And Fishery Management Practices, Michelle Robidas Jan 2023

What Drives Larval Condition For Northern Anchovy (Engraulis Mordax)? Implications For Coastal Pelagic Species Recruitment Fluctuations And Fishery Management Practices, Michelle Robidas

Theses

Discerning the causes of population boom and bust cycles for coastal pelagic species (CPS) has been a major focus of fisheries management research for over a century. Year-class strength is contingent on larval survival and condition, which can be influenced by larval size at age and growth rate. These two factors, in turn, can be affected by maternal investment and environmental variables such as water temperature, salinity, oxygen, and chlorophyll a. We evaluated each of these factors from 127 two to eight week-old Northern Anchovy (Engraulis mordax) larvae off the coast of San Diego to San Francisco, …


Assessing The Effectiveness Of Integrated Multi-Trophic Aquaculture For Growing West Coast Venus Clams, Avery Wallace Jan 2023

Assessing The Effectiveness Of Integrated Multi-Trophic Aquaculture For Growing West Coast Venus Clams, Avery Wallace

Theses

With demand for sustainable sources of seafood on the rise, California is looking to expand aquaculture with a focus on innovative culturing methods and use of native or resident species. Therefore, this study examined the potential for culturing native North American west coast venus clams (Chione californiensis and Chione undatella) using integrated multi-trophic aquaculture (IMTA). An ITMA approach was chosen because it is a culture method that uses species from different but functionally complementary trophic levels that have been found to reduce the potential negative effects of traditional monoculture. California sea cucumber (Parastichopus californicus) and the seaweeds red ogo (Gracilaria …


Ichthyofaunal Utilization Of A Man-Made Salt Marsh Creek In Mission Bay, California, 25 Years After Creation, Maria Angst, Drew M. Talley Aug 2022

Ichthyofaunal Utilization Of A Man-Made Salt Marsh Creek In Mission Bay, California, 25 Years After Creation, Maria Angst, Drew M. Talley

Research Month

Abstract: Southern California's wetlands are drastically declining due to human activities. Increasingly, marsh restoration and creation are being used to mitigate such losses. This study used minnow traps to resample the ichthyofauna of a created marsh (Crown Point Mitigation Site; CPMS) and an adjacent natural marsh (Kendall Frost) in Mission Bay, California, 26 years following the marsh creation. These data were compared to data collected from 1995-1998, immediately after marsh creation. Fishes trapped included Fundulus parvipinnis, Gillichthys mirabilis, Ctenogobius sagittula, Atherinops affinis, and Mugil cephalus. Species richness and dominance measures were higher in the natural …


Interannual Variation Of Ichthyofaunal Utilization Of A Man-Made Salt Marsh Creek In Mission Bay, California, Maria Angst Jul 2022

Interannual Variation Of Ichthyofaunal Utilization Of A Man-Made Salt Marsh Creek In Mission Bay, California, Maria Angst

McNair Summer Research Program

Southern California’s wetlands are drastically declining due to human activities. Increasingly, marsh restoration and creation are being used to mitigate such losses. This study used minnow traps to resample the ichthyofauna of a created marsh (Crown Point Mitigation Site; CPMS) and an adjacent natural marsh (Kendall Frost) in Mission Bay, California, 26 years following the marsh creation. These data were compared to data collected from 1995-1998, immediately after marsh creation, and data from 2021. Fishes captured included Fundulus parvipinnis, Gillichthys mirabilis, Acanthagobius flavimanus, Ctenogobius sagittula, and Mugil cephalus. Species richness and dominance measures were higher in the natural relative to …


Distribution Patterns Of The Invasive Mussel Arcuatula Senhousia In Mission Bay, San Diego, California: Effects Of Sediment Grain Size And Byssus Thread Production On Predation, Samantha Ahlman May 2022

Distribution Patterns Of The Invasive Mussel Arcuatula Senhousia In Mission Bay, San Diego, California: Effects Of Sediment Grain Size And Byssus Thread Production On Predation, Samantha Ahlman

Theses

The ability of bivalves to avoid predation by using defensive behaviors such as burrowing and byssus production may vary depending on the sediment characteristics of a given habitat. The varying sediment characteristics that change with water velocity within estuaries may influence the distribution of bivalves and limit them to areas that optimize their ability to defend against predators. We examined the distribution patterns of the invasive Asian date mussel Arcuatula senhousia relative to the sediment grain size distribution in Mission Bay, an urban estuary located in San Diego, California, USA. Mussels and sediment were collected using an Ekman grab at …


The Effect Of Different Feeding Regimes On Recent Nutritional And Growth Measurements In Juvenile California Killifish (Fundulus Parvipinnis), Emily Parks May 2022

The Effect Of Different Feeding Regimes On Recent Nutritional And Growth Measurements In Juvenile California Killifish (Fundulus Parvipinnis), Emily Parks

Theses

Gaining a deeper understanding of in-situ growth approximations for juvenile fishes is one way to understand how food consumption may affect fish growth. If variations in growth rate are strongly mirrored by past food status, then the condition (degree of well-being) of fish can be potentially used as a reference for relative prey availability. Furthermore, confirming that there is a positive relationship between food availability and fish growth rate is a critical first step to deepen our understanding of growth rate variation as well as examining if growth can be a proxy for habitat quality.

The California killifish (Fundulus …


Movement Patterns Of The Shovelnose Guitarfish (Pseudobatos Productus) And California Bat Ray (Myliobatis Californica) In The Southern California Bight, Annabel Gong Apr 2022

Movement Patterns Of The Shovelnose Guitarfish (Pseudobatos Productus) And California Bat Ray (Myliobatis Californica) In The Southern California Bight, Annabel Gong

Theses

While the movement patterns of large elasmobranch species have been studied extensively, those of smaller, mesopredatory species remain understudied. The shovelnose guitarfish (Pseudobatos productus) and the California bat ray (Myliobatis californica) are among the least studied elasmobranchs in the Southern California Bight. This study quantified the broad- and fine-scale movement patterns of these species using passive acoustic telemetry. Twelve guitarfish were surgically implanted with coded acoustic transmitters at a known aggregation site off La Jolla (San Diego County), California, USA and tracked for 849.5 days each, on average. Six bat rays were also implanted here and tracked for …


The Effect Of Marine Snow Particle Distribution On The Foraging Behavior Of Calanus Pacificus, Elena Beckhaus Jan 2022

The Effect Of Marine Snow Particle Distribution On The Foraging Behavior Of Calanus Pacificus, Elena Beckhaus

Theses

Marine snow is a major component of the biological pump, through which carbon is exported to the deep ocean. The sinking of marine snow can be disrupted by organisms, including many species of zooplankton that ingest or break up aggregates. These processes can have important impacts on planktonic food web dynamics and carbon export. Marine snow can have vertically patchy distributions, occurring in thin layers, which may further affect interactions with zooplankton. In this lab-based study, we examined how the presence of a marine snow layer affects copepod behavior and ingestion.

We conducted a series of experiments in which copepods …


Crassostrea Gigas Invasion In Southern California: Macrofaunal Diversity And Local Community Impacts Of Ecosystem Engineers On Estuarine Habitats, Noah Jansen-Yee Jan 2022

Crassostrea Gigas Invasion In Southern California: Macrofaunal Diversity And Local Community Impacts Of Ecosystem Engineers On Estuarine Habitats, Noah Jansen-Yee

Theses

Many marine ecosystems are facing the growing threat of biological invasions. These invasions can have a variety of different impacts on ecosystems and their inhabitants. The Pacific oyster, Crassostrea gigas, is currently in the relatively early stages of invasion in San Diego estuaries. Crassostrea gigas is a large, filter-feeding bivalve that forms dense oyster beds on hard substrate. These oysters are known to outcompete native counterparts and drastically alter habitats where they are present. Crassostrea gigas is an ecosystem engineer that, through shell creation and formation of a dense oyster matrix, impacts ecosystems in a variety of direct and indirect …


Ichthyofaunal Utilization Of A Man-Made Salt Marsh Creak In Mission Bay, California, 25 Years After Creation, Maria Angst Aug 2021

Ichthyofaunal Utilization Of A Man-Made Salt Marsh Creak In Mission Bay, California, 25 Years After Creation, Maria Angst

McNair Summer Research Program

Southern California’s wetlands are drastically declining due to human activities. Increasingly, marsh restoration and creation are being used to mitigate such losses. This study used minnow traps to resample the ichthyofauna of a created marsh (Crown Point Mitigation Site; CPMS) and an adjacent natural marsh (Kendall Frost) in Mission Bay, California, 26 years following the marsh creation. These data were compared to data collected from 1995-1998, immediately after marsh creation. Fishes trapped included Fundulus parvipinnis, Gillichthys mirabilis, Ctenogobius sagittula, Atherinops affinis, and Mugil cephalus. Species richness and dominance measures were higher in the natural relative to the created marsh. The …


Obesity Prevention Toolkit To Combat Weight Gain Related To Sedentary Behavior And Dietary Habits In College Students: An Evidence-Based Project, Maria Amos, Martha Fuller May 2021

Obesity Prevention Toolkit To Combat Weight Gain Related To Sedentary Behavior And Dietary Habits In College Students: An Evidence-Based Project, Maria Amos, Martha Fuller

Doctor of Nursing Practice Final Manuscripts

Abstract

Background: Forty percent of the US population ages 20-39 are categorized as obese,

their BMI is over 30, and 35% of college age students are obese or overweight. Issues related to obesity cost the US $147 billion annually. Between 40%-50% of college students are reported to be inactive. Inactivity can lead to increased morbidity and mortality related to increased risks of cardiovascular disease, diabetes, hypertension, musculoskeletal issues, and depression. Providing dietary and physical activity education and access to nutritional information promotes behavior change in young adults.

Aims of Service Change: This evidence-based project proposal aims to provide a toolkit …


Historical Ecology Of The San Diego Sport Fishery: Catch Composition, Species Trends, And Fishing Effort From 1959 To 2011, Rebecca Schwartz Lesberg Apr 2021

Historical Ecology Of The San Diego Sport Fishery: Catch Composition, Species Trends, And Fishing Effort From 1959 To 2011, Rebecca Schwartz Lesberg

Theses

Like ocean systems around the world, species targeted by the San Diego sportfishery are subject to myriad threats from human activity, with several species already showing documented decline. However, long-term fisheries datasets are often lacking, limiting natural resource managers’ ability to appropriately manage these ecologically and economically important species. Therefore, this study used daily reports published in two Southern California newspapers to examine changes in catch composition, effort, and catch per unit effort (CPUE) from 1959-2011 for the San Diego commercial passenger fishing vessel (CPFV) sportfishery. This study then tested the relationship between those patterns and three large scale oceanographic …


Life Satisfaction: Aging Female Informal Caregivers Of Persons With Dementia, Deborah Ann Monson Apr 2021

Life Satisfaction: Aging Female Informal Caregivers Of Persons With Dementia, Deborah Ann Monson

Dissertations

Purpose/Aims

The purpose of this study was to describe the relationship between aging female informal caregivers of persons with dementia (PWD) and care recipients’ PWD demographic factors, aging female informal caregivers of PWD social support factors, positive and negative feelings, a sense of flourishing, stress, and life satisfaction.

Background/Rationale

Older adults with dementia are living longer and the majority are receiving care by aging female informal caregivers. Dementia incrementally worsens over time impacting informal caregiver life satisfaction. Most studies have focused on negative aspects of informal caregiving. Therefore, this study investigated both positive and negative aspects of caregiving.

Conceptual Basis …


Using Aerial Photogrammetry And Sexually Dimorphic Measurements To Investigate Seasonal Differences In School Composition Of Delphinus Spp. Off Southern California, Samantha Gm Leander Jan 2021

Using Aerial Photogrammetry And Sexually Dimorphic Measurements To Investigate Seasonal Differences In School Composition Of Delphinus Spp. Off Southern California, Samantha Gm Leander

Theses

Insights into school composition can provide a means to understand basic biology and ecology, including reproductive patterns. They can also be applied to conservation assessments, allowing for better understanding of the potentially differential vulnerability of demographic groups to natural or anthropogenic disturbances that may influence their populations. However, the two subspecies of common dolphins in the waters off California (Delphinus delphis delphis and D. d. bairdii) form large, energetic groups that make characterization of school composition difficult. Remotely controlled drones now offer the opportunity for the study of school composition in Delphinus spp., allowing for precise morphometric measurements …


Developing A Method To Track Marine Snow Aggregation Through Individual Collisions Using Stereoscopic Imaging, Riley Henning Jan 2021

Developing A Method To Track Marine Snow Aggregation Through Individual Collisions Using Stereoscopic Imaging, Riley Henning

Theses

The aggregation of individual phytoplankton into marine snow allows particles to sink more quickly, thus resulting in the transport of particulate organic carbon from surface waters to the deep ocean. Aggregate formation has previously been measured in experiments indirectly by quantifying how particle size or particle concentration changes over time. Here, I present my thesis in which I applied high-resolution imaging to quantify aggregate formation using two different methodologies.

We conducted experiments to investigate aggregate formation using stereoscopic imaging, tracking individual particles directly in a 3D volume. Phytoplankton cultures were rolled in cylindrical tanks and imaged by two cameras illuminated …


The Effects Of Temperature And Body Size On The Metabolism And Hypoxia Tolerance Of White Abalone (Haliotis Sorenseni) And Red Abalone (H. Rufescens), Stephanie Fan Jan 2021

The Effects Of Temperature And Body Size On The Metabolism And Hypoxia Tolerance Of White Abalone (Haliotis Sorenseni) And Red Abalone (H. Rufescens), Stephanie Fan

Theses

In 2001, white abalone, Haliotis sorenseni, became the first marine invertebrate to be listed under the U.S. Endangered Species Act. Allee effects due primarily to overharvesting and disease resulted in individuals being too far apart for successful fertilization. Despite the fishery closure in 1996, H. sorenseni still shows no signs of recovery. Today, the White Abalone Recovery Consortium (WARC), a group that includes federal and state agencies, aquaculture organizations, academic institutions, and public aquaria, is working to recover this endangered species back from the brink of extinction.

In order to better understand the metabolic demands and hypoxia tolerance of the …


Otolith Microchemistry Reveals Low Habitat Connectivity Of California Killifish (Fundulus Parvipinnis) Across A Range Of Spatial Scales, Lisa Robison Jan 2021

Otolith Microchemistry Reveals Low Habitat Connectivity Of California Killifish (Fundulus Parvipinnis) Across A Range Of Spatial Scales, Lisa Robison

Theses

As wetlands face continued fragmentation worldwide, an understanding of habitat connectivity and how fishes that rely on these environments is imperative to conduct effective marine management. Site fidelity and habitat connectivity are vital measures of the interdependence of fish populations living in neighboring marshes (or in regions of a single marsh).

Here, we examine the habitat connectivity, site fidelity, and movement of California killifish (Fundulus parvipinnis) within and among three estuaries in Southern California through otolith microelemental analysis. Assessing the site fidelity of estuarine fishes is important to determine the level of connectivity between spatially distinct populations within …


Diet Of An Important Wetland Resident, The California Killifish, Fundulus Parvipinnis, In A Natural And Created Marsh Habitat In Mission Bay, California, Katie Robinson-Filipp Jan 2021

Diet Of An Important Wetland Resident, The California Killifish, Fundulus Parvipinnis, In A Natural And Created Marsh Habitat In Mission Bay, California, Katie Robinson-Filipp

Theses

The California killifish, Fundulus parvipinnis Girard, is an ecologically important marsh resident. Fundulus parvipinnis is a low-level carnivore, displaying high-site fidelity and occurring in high densities across a range of environmental conditions. Despite the importance of F. parvipinnis to the ecosystem functions of the threatened coastal wetlands of southern California and the Baja California Peninsula, there are critical gaps in our knowledge of this species. In particular, information on their diet and food habits is lacking.

Understanding wetland food web linkages, interactions, and trophic transfer is essential for informing effective habitat management and contributes to our ability to evaluate the …


Algal Wrack Community Composition And Succession On A Sandy Beach In San Diego, Ca, Marisol Palomares Dec 2020

Algal Wrack Community Composition And Succession On A Sandy Beach In San Diego, Ca, Marisol Palomares

Theses

Sandy beaches are high-energy impact zones that produce little to no organic material. Much of the organic matter on beaches is washed up on shore in the form of algal wrack, providing a vital source of nutrients, food, and habitat for a variety of organisms on the sandy beach. Over time wrack will decay and decompose, releasing nutrients including nitrogen and phosphorus, which are consumed by benthic microalgae and bacteria. The type of wrack and geomorphology of the beach environments affect decomposition, which in turn supports a variety of different wrack associated macrofaunal communities. Different species of algal wrack will …


Diverse Community Of Arsenic Resistant Bacteria Display Arsenate Reducing Capabilities, Stephanie Maeda Oct 2020

Diverse Community Of Arsenic Resistant Bacteria Display Arsenate Reducing Capabilities, Stephanie Maeda

Undergraduate Honors Theses

Naturally found in soil and water environments arsenic is toxic to many organisms, carcinogenic to humans, and poses a significant public health risk. Yet communities of bacteria found thriving in arsenic ridden environments have evolved mechanisms to tolerate and exploit both oxidation states of this heavy metal (arsenite and arsenate). As the site of an old arsenic mine, Black Mountain Open Space Park in San Diego, California has yielded concentrations of arsenic in the soil between 111-14,800 ppm. Exceeding average arsenic soil concentrations and levels considered safe in the environment by the World Health Organization, we sought to characterize the …


The Effect Of Phytoplankton Properties On The Ingestion Of Marine Snow By Calanus Pacificus, Grace Cawley Aug 2020

The Effect Of Phytoplankton Properties On The Ingestion Of Marine Snow By Calanus Pacificus, Grace Cawley

Theses

The aggregation of phytoplankton into marine snow provides a mechanism by which smaller particles can coagulate to form larger particles, which can be consumed at various depths or readily transported to the deep ocean and sequestered from the atmosphere on time scales of a thousand years or more. Zooplankton interacting with these large carbon-rich aggregates can obtain nutrition in environments where the phytoplankton size spectrum is small and not directly available, enhancing the possibility of obtaining adequate nutrition in environments dominated by small cells. In addition, interactions between zooplankton and marine snow can result in fragmentation, thus affecting the particle …


La Habana: A History Of Society, Livelihood, Movement, And Land Use On The Iquitos-Nauta Highway, Katie Brown May 2020

La Habana: A History Of Society, Livelihood, Movement, And Land Use On The Iquitos-Nauta Highway, Katie Brown

Undergraduate Honors Theses

With increasing infrastructural projects and land titling in the Peruvian Amazon, many changes are occurring within small roadside communities. In this case study, we investigate how these changes impact livelihoods, land use, travel patterns, and social relations within the broader concepts of development, privatization of land, and commodification of nature. Specifically we focus on the caserío La Habana situated on the Iquitos-Nauta highway in the Loreto region of Peru. Semi-formal interviews and ethnographic methods were conducted to gather information on social organization, history of the community, land use practices, migration patterns, opinions on the road, and livelihood strategies. After data …


Screening For Iron-Deficiency Anemia In The Pediatric Population (Ages 1-17) In Gonaïves, Haiti, Cara Rose Fratianni May 2020

Screening For Iron-Deficiency Anemia In The Pediatric Population (Ages 1-17) In Gonaïves, Haiti, Cara Rose Fratianni

Doctor of Nursing Practice Final Manuscripts

Abstract

Purpose: The purpose of this pilot project is to screen for iron-deficiency anemia in pediatric patients (ages 1-17) in a primary school in Gonaïves, Haiti. Patients with anemia will be treated with oral supplemental iron for a period of four weeks according to WHO guidelines (WHO, 2011). All students will be treated empirically for helminths per WHO guidelines, unless treated elsewhere in the last six months (WHO, 2017). Nutritional status will also be assessed using MUAC according to WHO guidelines (2017).

Background Summary: Malnutrition contributes significantly to the problem of iron-deficiency anemia, with one in four children exhibiting stunting …


Sleep Modifications In A Drosophila Melanogaster Model Of Fragile X Syndrome, Morgan Mclaughlin May 2020

Sleep Modifications In A Drosophila Melanogaster Model Of Fragile X Syndrome, Morgan Mclaughlin

Undergraduate Honors Theses

Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disabilities, disruptions in sleep, and autism in humans. Mutations in Fragile X Mental Retardation gene 1 (FMR1), which codes for a protein that modifies the expression of many target proteins, are primarily responsible for this disorder. Genetic modifications of FMR1 can increase or decrease the overall amount of sleep in humans. A potential pharmaceutical target of FXS is dopamine, a critical neurotransmitter in the regulation of sleep and wakefulness. In fruit flies (Drosophila melanogaster) dopamine has been shown to alter sleep. The mushroom body, a structure in …