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University of North Florida

2011

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Articles 1 - 9 of 9

Full-Text Articles in Life Sciences

Examination Of The Mitochondrial Health Of The Basigin Null Mouse Retina, Kristine Anne V. Pablo Jan 2011

Examination Of The Mitochondrial Health Of The Basigin Null Mouse Retina, Kristine Anne V. Pablo

UNF Graduate Theses and Dissertations

Basigin gene products are cell adhesion molecules that are expressed by photoreceptor cells, Müller cells and endothelial cells of the mammalian retina. Previous studies have suggested that a lactate shuttle exists between the photoreceptor cells and the Müller cells, with Basigin being an essential component in this shuttle. Deletion of the Basigin gene in mice results in blindness with an eventual retinal degeneration. It was hypothesized that the lactate shuttle between photoreceptors and Müller cells does not form in Basigin null mice and that the blindness is attributed to faulty photoreceptor metabolism. Therefore, the purpose of this study was to …


Protein Expression Of Hypoxia-Inducible Factor 1-Alpha (Hif-1Α) In Spot (Leiostomus Xanthurus) Under Acute Exposure To Hypoxic Treatments : A Laboratory-Field Comparison Study, Mason James Smith Jan 2011

Protein Expression Of Hypoxia-Inducible Factor 1-Alpha (Hif-1Α) In Spot (Leiostomus Xanthurus) Under Acute Exposure To Hypoxic Treatments : A Laboratory-Field Comparison Study, Mason James Smith

UNF Graduate Theses and Dissertations

Hypoxia in coastal estuaries is a topic of increasing concern, as the magnitude and frequency of hypoxic events have increased over the past several decades. These hypoxic events are highly detrimental to the coastal biota, particulary fish. The hypoxia-inducible factor 1α (HIF-1α) protein was used as a candidate biomarker for deciphering exposure of fish to hypoxic events. In chapter one, Spot (Leiostomus xanthurus) were exposed to three treatment groups of DO (means 7.32 ± 0.18, 5.15 ± .37, and 2.57 ± 0.01 mg Lˉ¹ DO) and sampled (n = 5) at time zero, 36 and 72-h for each treatment. The …


Assessing The Effects Of Pollutant Exposure On Sharks: A Biomarker Approach, Christina J. Walker Jan 2011

Assessing The Effects Of Pollutant Exposure On Sharks: A Biomarker Approach, Christina J. Walker

UNF Graduate Theses and Dissertations

Many hydrophobic environmental pollutants have been shown to bioaccumulate and biomagnify at high levels in sharks due to their high liver lipid content, high trophic level, and life history characteristics. Studies have demonstrated that the levels of pollutants present in shark tissues can not only exceed the recommended levels for human consumption, but that, in some cases, they are also greater than the threshold for physiological effect in other aquatic species. However, few studies to date have investigated the biological effect of environmental exposure to contaminants in sharks. Therefore, the goal of this study was to investigate, through the use …


Characterization Of Basigin And The Interaction Between Embigin And Monocarboxylate Transporter-1, -2, And -4 (Mct1, Mct2, Mct4) In The Mouse Brain, L Nicole Little Jan 2011

Characterization Of Basigin And The Interaction Between Embigin And Monocarboxylate Transporter-1, -2, And -4 (Mct1, Mct2, Mct4) In The Mouse Brain, L Nicole Little

UNF Graduate Theses and Dissertations

Basigin and Embigin are members of the immunoglobulin superfamily that function as cell adhesion molecules. Studies of Basigin null mice revealed reproductive sterility, increased pain sensitivity, and blindness. It is thought that the mechanism causing blindness involves misexpression of monocarboxylate transporter 1 (MCT1) in the absence of Basigin. It is known that the transmembrane domain of Basigin interacts with MCT1. In the absence of Basigin, MCT1 does not localize to the plasma membrane of expressing cells and photoreceptor function is disrupted. Studies of the Basigin null mouse brain suggest that MCT1 is properly expressed, which suggests a separate mechanism causes …


Localization And Characterization Of The Interactions Between Basigin Gene Products And Monocarboxlate Transporters In The Olfactory Bulb Of The Mouse, Paul L. Gambon Jan 2011

Localization And Characterization Of The Interactions Between Basigin Gene Products And Monocarboxlate Transporters In The Olfactory Bulb Of The Mouse, Paul L. Gambon

UNF Graduate Theses and Dissertations

Basigin, the mouse form of the human protein EMMPRIN, is commonly found as a transmembrane homodimer with carboxy termini in the cytosol and extracellular amino-termini. Because of its important role as a cell-to-cell junction molecule, and possible implications for cancer research, a Basigin null mouse was developed in 1996 by Igakura et al., to aid in the study of this protein. Their early research demonstrated that Basigin plays a large role in embryonic development. Mice lacking the Basigin gene are blind from the time of eye opening, and have demonstrated a lack of aversion to offensive odors such as acetic …


Bumblebees 2010-2011, Mandarin Garden Club Jan 2011

Bumblebees 2010-2011, Mandarin Garden Club

Mandarin Garden Club Scrapbooks

Scrapbook includes images, club news, news clippings and 3-D embellishments. Cover material: Plastic. Size: 11.625" x 10.125" x 2. 375".


State Of The River Report For The Lower St. Johns River Basin, Florida: Water Quality, Fisheries, Aquatic Life, And Contaminants 2011, Environmental Protection Board, City Of Jacksonville, University Of North Florida, Jacksonville University Jan 2011

State Of The River Report For The Lower St. Johns River Basin, Florida: Water Quality, Fisheries, Aquatic Life, And Contaminants 2011, Environmental Protection Board, City Of Jacksonville, University Of North Florida, Jacksonville University

State of the River Report

No abstract provided.


2009-2011, Mandarin Garden Club Jan 2011

2009-2011, Mandarin Garden Club

Mandarin Garden Club Scrapbooks

Scrapbook includes images, club news and news clippings. Cover material: Cardboard. Size: 12.5" x 13.5 x 1.0625". Date: 2009-2011


Physiology And Biochemistry Of The Tropical Seagrass Thalassia Testudinum In Response To Hypersalinity Stress And Labyrinthula Sp. Infection, Stacey Marie Trevathan-Tackett Jan 2011

Physiology And Biochemistry Of The Tropical Seagrass Thalassia Testudinum In Response To Hypersalinity Stress And Labyrinthula Sp. Infection, Stacey Marie Trevathan-Tackett

UNF Graduate Theses and Dissertations

Seagrass meadows are essential to coastal ecosystems and have experienced declines in abundance due to a series of environmental stressors including elevated salinity and incidence of disease caused by the pathogen Labyrinthula sp. This thesis evaluated the dynamics between T. testudinum and Labyrinthula concerning the impacts of short term elevated salinity stress on the early stages of infection in Thalassia testudinum (Chapter 2) as well as the presence of anti-labyrinthulid secondary metabolites produced by the tropical seagrass (Chapter 3). The results showed that short term exposure to hypersalinity alters some cellular processes but does not necessarily lead to an immediate …