Life Sciences Commons^™

Ability Of Functional Performance Tests To Identify Individuals With Chronic Ankle Instability: A Systematic Review With Meta-Analysis, Adam B. Rosen, Alan R. Needle, Jupil Ko

Health and Kinesiology Faculty Publications

Objective:

The purpose of this systematic review with meta-analysis was to determine the effectiveness of functional performance tests (FPTs) in differentiating between individuals with chronic ankle instability (CAI) and healthy controls.

Data Sources:

The National Library of Medicine Catalog (PubMed), the Cumulative Index for Nursing and Allied Health Literature (CINAHL), and the SPORTDiscus, from inception to June 2017 were searched. Search terms consisted of: “Functional Performance Test*” OR “Dynamic Balance Test*” OR “Postural Stability Test*” OR “Star Excursion Balance Test*” OR “Hop Test*” AND “Ankle Instability” OR “Ankle Sprain.” Included articles assessed differences in FPTs in patients with CAI compared …

Editorial: Murine Models Of Leukemia And Lymphoma, Christine E. Cutucache, Pierluigi Porcu

Biology Faculty Publications

Murine models serve as an effective way to mimic the in vivo tumor microenvironmental interactions that take place in patients with leukemias and lymphomas. Specifically, leukemias and lymphomas rely heavily on the surrounding stroma and tissue microenvironmental cytokine and chemokine signals to ensure survival and expansion of tumor cells. Finally, leukemic cells migrate thanks to signals from varying regions of the host, furthering the progression and severity of disease. It is therefore impossible to fully understand such a dynamic relationship between tumor cells and their surrounding microenvironment, and the events to transformation in leukemias and lymphomas without an in vivo, …

Reduced Vertical Displacement Of The Center Of Mass Is Not Accompanied By Reduced Oxygen Uptake During Walking, Shane R. Wurdeman, Peter C. Raffalt, Nicholas Stergiou

Journal Articles

The six determinants of gait proposed that the goal of gait is to minimize vertical displacement of the body’s center of mass (CoM) with the objective to optimize energy expenditure. On the contrary, recent investigations suggest that reduced vertical displacement leads to an increase in energy expenditure. However, these investigations had the included subjects deliberately changing their gait, which could bias the endpoint measures. The present study investigated the effect of reduced vertical displacement of the CoM on oxygen uptake and walking economy without imposing altered gait patterns. This was accomplished by having subjects walk on a curved treadmill and …

Analyzing Coxsackievirus B3 Genomic Rna By Site Directed Mutagenesis And Shape Analysis, Sara Smith

Theses/Capstones/Creative Projects

Virulent Coxsackievirus B3 (CVB3) is linked to myocarditis, pancreatitis, and type I diabetes. Avirulent CVB3 doesn’t cause disease. CVB3 possesses a positive, single-stranded ribonucleic acid (RNA) genome containing 7,400 nucleotides, organized into four sections: a 5’ untranslated region (5’ UTR), a single open reading frame, a 3’ untranslated region, and a poly-A tail. The 5’ UTR is 743 nucleotides divided into 7 domains. Mutations within the 5’ UTR can alter RNA structure, and thus alter virulence. Nucleotide associations responsible for higher level RNA folding patterns and structure haven’t been defined. We are investigating the 5’ UTR by selective 2’ hydroxyl …

Biomechanics (Chapter 9), Nicholas Stergiou, K.-C. Siu, Sara Myers, Ben Senderling

Journal Articles

Biomechanics is a discipline. A discipline deals with understanding, predicting, and explaining phenomena within a content domain, and biomechanics is the study of the human body in motion. Kinesiology, the parent discipline of biomechanics, is a science that investigates movement. Biomechanical research in human development focuses on evaluating essential movement patterns across the human life span. Biomechanical analysis is specifically important in quantifying the developmental motor skills and movement patterns such as walking, kicking, jumping, throwing, and catching. Biomechanical research also involves studying the movement patterns of injured and disabled people. Forensic biomechanists are invited to analyze evidence, clarify some …

Energy Neutral: The Human Foot And Ankle Subsections Combine To Produce Near Zero Net Mechanical Work During Walking, Kota Z. Takahashi, Kate Worster, Dustin A. Bruening

Journal Articles

The human foot and ankle system is equipped with structures that can produce mechanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad) mechanisms, or by active muscle contractions. Yet, quantifying the work distribution among various subsections of the foot and ankle can be difficult, in large part due to a lack of objective methods for partitioning the forces acting underneath the stance foot. In this study, we deconstructed the mechanical work production during barefoot walking in a segment-by-segment manner (hallux, forefoot, hindfoot, and shank). This was accomplished by isolating the forces acting within each foot …

Functional Changes Through The Usage Of 3d-Printed Transitional Prostheses In Children, Jorge Zuniga, Jean Peck, Rakesh Srivastava, James E. Pierce, Drew Dudley, Nicholas T. Than, Nicholas Stergiou

Journal Articles

Introduction: There is limited knowledge on the use of 3 D-printed transitional prostheses, as they relate to changes in function and strength. Therefore, the purpose of this study was to identify functional and strength changes after usage of 3 D-printed transitional prostheses for multiple weeks for children with upper-limb differences.

Materials and methods: Gross manual dexterity was assessed using the Box and Block Test and wrist strength was measured using a dynamometer. This testing was conducted before and after a period of 24 ± 2.61 weeks of using a 3 D-printed transitional prosthesis. The 11 children (five girls and six …

Filamentation Involves Two Overlapping, But Distinct, Programs Of Filamentation In The Pathogenic Fungus Candida Albicans, Jahaun Azadmanesh, Austin M. Gowen, Paul E. Creger, Nicole D. Shafer, Jill R. Blankenship

Biology Faculty Publications

The ability of the human pathogenic fungus Candida albicans to switch between yeast-like and filamentous forms of growth has long been linked to pathogenesis. Numerous environmental conditions, including growth at high temperatures, nutrient limitation, and exposure to serum, can trigger this morphological switch and are frequently used in in vitro models to identify genes with roles in filamentation. Previous work has suggested that differences exist between the various in vitro models both in the genetic requirements for filamentation and transcriptional responses to distinct filamentation-inducing media, but these differences had not been analyzed in detail. We compared 10 in vitro models …

Measuring Coupling Of Rhythmical Time Series Using Cross Sample Entropy And Cross Recurrence Quantification Analysis, John D. Mccamley, William Denton, Elizabeth E. Lyden, Jennifer M. Yentes

Journal Articles

The aim of this investigation was to compare and contrast the use of cross sample entropy (xSE) and cross recurrence quantification analysis (cRQA) measures for the assessment of coupling of rhythmical patterns. Measures were assessed using simulated signals with regular, chaotic, and random fluctuations in frequency, amplitude, and a combination of both. Biological data were studied as models of normal and abnormal locomotor-respiratory coupling. Nine signal types were generated for seven frequency ratios. Fifteen patients with COPD (abnormal coupling) and twenty-one healthy controls (normal coupling) walked on a treadmill at three speeds while breathing and walking were recorded. xSE and …

Healthy Families: A Family-Based Community Intervention To Address Childhood Obesity, Danae Dinkel, Melissa Tibbits, Emily Hanigan, Kelly Nielsen, Leah Jorgensen, Kay Grant

Health and Kinesiology Faculty Publications

The objective of this study was to determine the effectiveness of Healthy Families, a family-based community intervention, in improving the knowledge, self-efficacy, and health behaviors of overweight/obese children and their families as well as to explore the lessons learned. Results showed families who completed the program had significant improvements for children and parents in areas such as nutrition knowledge and self-efficacy in making healthy eating choices as well as participating in physical activity. Additionally, families reported decreasing their intake of sugar-sweetened beverages. Participating families and community partners provided valuable lessons for other communities seeking to implement a similar program.

Reliability Of A Feedback-Controlled Treadmill Algorithm Dependent On The User's Behavior, Casey Wiens, William Denton, Molly Schieber, Ryan Hartley, Vivien Marmelat, Sara A. Myers, Jennifer M. Yentes

Journal Articles

he reliability of the treadmill belt speed using a feedback-controlled treadmill algorithm was analyzed in this study. Using biomechanical factors of the participant's walking behavior, an estimated walking speed was calculated and used to adjust the speed of the treadmill. Our proposed algorithm expands on the current hypotheses of feedback-controlled treadmill algorithms and is presented below. Nine healthy, young adults walked on a treadmill controlled by the algorithm for three trials over two days. Each participant walked on the feedback-controlled treadmill for one 16-minute and one five-minute trial during day one and one 16-minute trial during day two. Mean, standard …

Multifractality, Interactivity, And The Adaptive Capacity Of The Human Movement System: A Perspective For Advancing The Conceptual Basis Of Neurologic Physical Therapy, Jon Cavanaugh, Damian G. Kelty-Stephen, Nicholas Stergiou

Journal Articles

Background and Purpose:

Physical therapists seek to optimize movement as a means of reducing disability and improving health. The short-term effects of interventions designed to optimize movement ultimately are intended to be adapted for use across various future patterns of behavior, in potentially unpredictable ways, with varying frequency, and in the context of multiple tasks and environmental conditions. In this perspective article, we review and discuss the implications of recent evidence that optimal movement variability, which previously had been associated with adaptable motor behavior, contains a specific complex nonlinear feature known as “multifractality.”

Summary of Key Points:

Multifractal movement fluctuation …

Assessment Of Human Adipose Tissue Microvascular Function Using Videomicroscopy, Melissa G. Farb, Song-Young Park, Shakun Karki, Noyan Gokce

Health and Kinesiology Faculty Publications

While obesity is closely linked to the development of metabolic and cardiovascular disease, little is known about mechanisms that govern these processes. It is hypothesized that pro-atherogenic mediators released from fat tissues particularly in association with central/visceral adiposity may promote pathogenic vascular changes locally and systemically, and the notion that cardiovascular disease may be the consequence of adipose tissue dysfunction continues to evolve. Here, we describe a unique method of videomicroscopy that involves analysis of vasodilator and vasoconstrictor responses of intact small human arterioles removed from the adipose depot of living human subjects. Videomicroscopy is used to examine functional properties …

An Overview Of Assessment Methodology For Obesity-Related Variables In Infants At Risk, Danae Dinkel, Corrine Hanson, Karsten Koehler, Ann Anderson Berry, Anastasia Kyvelidou, Matthew Bice, Jill Wallen, Danstan Bagenda, Laura Jana, Jana Pressler

Health and Kinesiology Faculty Publications

Background: The first 2 years of a child’s life are a particularly critical time period for obesity prevention.

Aim: An increasing amount of research across the world is aimed at understanding factors that impact early childhood obesity and developing interventions that target these factors effectively. With this growing interest, new and interdisciplinary research teams are developing to meet this research need. Due to rapid growth velocity during this phase of the lifespan, typical assessments used in older populations may not be valid or applicable in infants, and investigators need to be aware of the pros and cons of …

Human-In-The-Loop Bayesian Optimization Of Wearable Device Parameters, Myunghee Kim, Ye Ding, Philippe Malcolm, Jozefien Speeckaert, Christopher Siviy, Conor J. Walsh

Journal Articles

The increasing capabilities of exoskeletons and powered prosthetics for walking assistance have paved the way for more sophisticated and individualized control strategies. In response to this opportunity, recent work on human-in-the-loop optimization has considered the problem of automatically tuning control parameters based on realtime physiological measurements. However, the common use of metabolic cost as a performance metric creates significant experimental challenges due to its long measurement times and low signal-to-noise ratio. We evaluate the use of Bayesian optimization—a family of sample-efficient, noise-tolerant, and global optimization methods—for quickly identifying near-optimal control parameters. To manage experimental complexity and provide comparisons against related …

Cross-Cultural Adaptation, Reliability, And Validation Of The Korean Version Of The Identification Functional Ankle Instability (Idfai), Jupil Ko, Adam B. Rosen, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Purpose: To cross-culturally adapt the Identification Functional Ankle Instability for use with Korean-speaking participants.

Methods: The English version of the IdFAI was cross-culturally adapted into Korean based on the guidelines. The psychometric properties in the Korean version of the IdFAI were measured for test-retest reliability, internal consistency, criterion-related validity, discriminative validity, and measurement error 181 native Korean-speakers.

Results: Intra-class correlation coefficients (ICC2,1) between the English and Korean versions of the IdFAI for test–retest reliability was 0.98 (standard error of measurement = 1.41). The Cronbach’s alpha coefficient was 0.89 for the Korean versions of IdFAI. The Korean versions of the IdFAI …

Diagnosis Of A Chiari Malformation After A Concussion In A Junior College Football Player With A History Of Chronic Headaches: A Case Report, Takeaki Ando, Shannon Gehr, Melanie L. Mcgrath, Adam B. Rosen

Health and Kinesiology Faculty Publications

The purpose of this report is to present the case of a National Junior Collegiate Athletic Association football player diagnosed with Chiari malformation postconcussion. A Chiari malformation is characterized by the cerebellum presenting below the level of the foramen. The uniqueness of this case stems from the patient’s health history, length of symptoms, and diagnosis. The effectiveness of treatment options, and the primary means to reduce the risk of catastrophic head injury in those with Chiari malformations are debatable. Clinicians should be familiar with the potential for the presence of a Chiari malformation with persistent symptoms postconcussion.

Dynamics Of Stride Interval Characteristics During Continuous Stairmill Climbing, Peter C. Raffalt, Srikant Vallabhajosula, Jessica J. Renz, Mukul Mukherjee, Nikolaos Stergiou

Journal Articles

It has been shown that statistical persistence in stride intervals characteristics exist during walking, running and cycling and were speed-dependent among healthy young adults. The purpose of this study was to determine if such statistical persistence in stride time interval, stride length and stride speed also exists during self-paced continuous stairmill climbing and if the strength is dependent on stepping rate. Stride time, stride length, and stride speed were collected from nine healthy participants during 3 min of stairmill climbing at 100, 110, and 120% of their preferred stepping rate (PSR) and 5 min of treadmill walking at preferred walking …

Single-Limb Landing Biomechanics Are Altered And Patellar Tendinopathy Related Pain Is Reduced With Acute Infrapatellar Strap Application, Adam B. Rosen, Jupil Ko, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Background

Patellar tendinopathy, a common condition of the knee, is often treated with patellar tendon straps to control pain during dynamic activity. Little is known regarding their effect on pain, landing kinematics and kinetics with their application. The purpose of this study was to determine if patellar tendon straps influenced pain, kinematics at landing and ground reaction forces in individuals with patellar tendinopathy versus healthy controls.

Methods

Thirty participants with patellar tendinopathy and 30 controls participated. They completed single-limb landings with and without patellar tendon straps while pain, three-dimensional kinematics and vertical ground reaction forces were measured. A multivariate …

Dynamic Balance Changes Within Three Weeks Of Fitting A New Prosthetic Foot Component, Jenny A. Kent, Nicholas Stergiou, Shane R. Wurdeman

Journal Articles

Balance during walking is of high importance to prosthesis users and may affect walking during baseline observation and evaluation. The aim of this study was to determine whether changes in walking balance occurred during an adaptation period following the fitting of a new prosthetic component.

Margin of stability in the medial-lateral direction (MOSML) and an anterior instability margin (AIM) were used to quantify the dynamic balance of 21 unilateral transtibial amputees during overground walking. Participants trialled two prosthetic feet presenting contrasting movement/balance constraints; a Higher Activity foot similar to that of their own prosthesis, and a Lower Activity foot. Participants …

Trpv1 Channels In Human Skeletal Muscle Feed Arteries: Implications For Vascular Function, Stephen J. Ives, Song-Young Park, Oh-Sung Kwon, Jayson R. Gifford, Robert H. I. Andtbacka, John R. Hyngstrom, Russell S. Richardson

Health and Kinesiology Faculty Publications

New Findings

• What is the central question of this study?

  We sought to determine whether human skeletal muscle feed arteries (SFMAs) express TRPV1 channels and what role they play in modulating vascular function.

• What is the main finding and its importance?

  Human SMFAs do express functional TRPV1 channels that modulate vascular function, specifically opposing α-adrenergic receptor-mediated vasocontraction and potentiating vasorelaxation, in an endothelium-dependent manner, as evidenced by the α1-receptor-mediated responses. Thus, the vasodilatory role of TRPV1 channels, and their ligand capsaicin, could be a potential therapeutic target for improving vascular function. Additionally, given the ‘sympatholytic’ effect of TRPV1 activation and …

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Wnt5a Regulates Adipose Tissue Angiogenesis Via Antiangiogenic Vegf-A165b In Obese Humans, Melissa G. Farb, Doan T.M. Ngo, Song-Young Park, Samantha M. Saggese, Naomi M. Hamburg, Brian Carmine, Donald T. Hess, Kenneth Walsh, Noyan Gokce

Health and Kinesiology Faculty Publications

Experimental studies have suggested that Wingless-related integration site 5A (WNT5A) is a proinflammatory secreted protein that is associated with metabolic dysfunction in obesity. Impaired angiogenesis in fat depots has been implicated in the development of adipose tissue capillary rarefaction, hypoxia, inflammation, and metabolic dysfunction. We have recently demonstrated that impaired adipose tissue angiogenesis is associated with overexpression of antiangiogenic factor VEGF-A165b in human fat and the systemic circulation. In the present study, we postulated that upregulation of WNT5A is associated with angiogenic dysfunction and examined its role in regulating VEGF-A165b expression in human obesity. We biopsied subcutaneous and visceral adipose …

Comparison Between Single And Combined Clinical Postural Stability Tests In Individuals With And Without Chronic Ankle Instability, Jupil Ko, Adam B. Rosen, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Objective: To determine if a single or/and combined clinical tests match group membership based on self-reported ankle function.

Design: Cross-sectional.

Setting: Biomechanics Laboratory.

Participants: From participants, 58 meeting inclusion/exclusion criteria were divided into a chronic ankle instability (CAI) group (n = 25) who reported ≤25 on the Cumberland Ankle Instability Tool (CAIT) and a history of moderate–severe ankle sprain(s) and a control group (n = 33) who reported ≥29 on the CAIT and no history of ankle sprain(s).

Interventions: Participants completed the following clinical tests: Foot Lift Test (FLT), the Star Excursion Balance Test (SEBT), the Single-Leg Hop Test (SLHT), …

Muscle Strength And Control Characteristics Are Altered By Peripheral Artery Disease, Molly Schieber, Ryan Hasenkamp, Iraklis Pipinos, Jason Johanning, Nicholas Stergiou, Holly Despiegelaere, Jung Chien, Sara A. Myers

Journal Articles

Objective

Methods

Patellar Tendon Straps Decrease Pain And May Alter Lower Extremity Kinetics In Those With Patellar Tendinopathy During Jump Landing, Adam B. Rosen, Jupil Ko, Kathy J. Simpson, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Patellar tendinopathy is often managed with a patellar tendon strap, however, their effectiveness is unsubstantiated. The purpose of this study was to determine if straps altered pain or lower extremity kinetics of individuals with patellar tendinopathy during landing. Thirty participants with patellar tendinopathy and 30 controls completed drop jumps with and without patellar tendon straps. Wearing the strap, tendinopathy participants demonstrated significantly decreased pain and reduced knee adductor moment; all participants displayed significantly decreased anterior ground reaction force while wearing a strap. Patellar tendon strapping may reduce pain due to alterations in direction and magnitude of loading.

An Examination Of Estimated Bmi And Perceived Wellness Among Students At A Midsized Midwest University, Kylie Kenedy, Eric M. Wiedenman, James W. Ball, Danae Dinkel, Kazuma Akehi, Matthew R. Bice

Health and Kinesiology Faculty Publications

Health is complex and the perception of individual wellness can be influenced by various factors. Students at a Midwestern university estimated their BMI, completed the Perceived Wellness Survey, and had their BMI calculated. Measured BMI was significantly higher than estimated [F(2,155) = 62.03, p = 0.001]. Associations existed between the measured constructs of psychological (r = -0.231; p = 0.004), spiritual (r = 0.248; p = 0.002), and estimated BMI. Data indicates that perceived body composition is related to wellness. False perception of body composition could lead to wellness deficiencies.

Affordances In The Home Environment For Motor Development-Infant Scale, Spanish Translation, Danae Dinkel, Kailey Snyder, Priscila Cacola

Health and Kinesiology Faculty Publications

The home environment has a critical influence on an infant’s development and well-being. The Affordances in the Home Environment for Motor Development-Infant Scale (AHEMD-IS) is an instrument that has been developed to assess the home environment. This article illustrates the translation, validation, and cultural adaptation process of the AHEMD-IS from English to Spanish. The AHEMD-IS underwent a comprehensive process involving a four-phase translation process: (1) Forward translation, (2) Semantic equivalence, (3) Content equivalence testing, and (4) Final version development. Steps 1 and 2 resulted in linguistic alterations from the initial translation to enhance clarity for general public understanding. In step …

Gait Deficiencies Associated With Peripheral Artery Disease Are Different Than Chronic Obstructive Pulmonary Disease, John D. Mccamley, Eric J. Pisciotta, Jennifer M. Yentes, Shane R. Wurdeman, Stephen I. Rennard, Iraklis I. Pipinos, Jason M. Johanning, Sara A. Myers

Journal Articles

Objective: Previous studies have indicated that patients with peripheral artery disease (PAD), display significant differences in their kinetic and kinematic gait characteristics when compared to healthy, aged-matched controls. The ability of patients with chronic obstructive pulmonary disease (COPD) to ambulate is also limited. These limitations are likely due to pathology-driven muscle morphology and physiology alterations establish in PAD and COP, respectively. Gait changes in PAD were compared to gait changes due to COPD to further understand how altered limb muscle due to disease can alter walking patterns. Both groups were independently compared to healthy controls. It was hypothesized that both …

Varying Negative Work Assistance At The Ankle With A Soft Exosuit During Loaded Walking, Philippe Malcolm, Sangjun Lee, Simon Crea, Christopher Siviy, Fabricio Saucedo, Ignacio Galiana, Fausto A. Panizzolo, Kenneth G. Holt, Conor J. Walsh

Journal Articles

Background: Only very recently, studies have shown that it is possible to reduce the metabolic rate of unloaded and loaded walking using robotic ankle exoskeletons. Some studies obtained this result by means of high positive work assistance while others combined negative and positive work assistance. There is no consensus about the isolated contribution of negative work assistance. Therefore, the aim of the present study is to examine the effect of varying negative work assistance at the ankle joint while maintaining a fixed level of positive work assistance with a multi-articular soft exosuit.

Methods: We tested eight participants during …

Muscle Strength And Control Characteristics Are Altered By Peripheral Artery Disease, Molly Schieber, Ryan Hasenkamp, Iraklis Pipinos, Jason Johanning, Nicholas Stergiou, Holly Despiegelaere, Jung Chien, Sara Myers

Journal Articles

Objective

Peripheral artery disease (PAD), a common manifestation of atherosclerosis, is characterized by lower leg ischemia and myopathy in association with leg dysfunction. Patients with PAD have impaired gait from the first step they take with consistent defects in the movement around the ankle joint, especially in plantar flexion. Our goal was to develop muscle strength profiles to better understand the problems in motor control responsible for the walking impairment in patients with PAD.

Methods

Ninety-four claudicating PAD patients performed maximal isometric plantar flexion contractions lasting 10 seconds in two conditions: pain free (patient is well rested and has …