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Recent Insights Into Muscle Fatigue At The Cross-Bridge Level, Edward Debold
Recent Insights Into Muscle Fatigue At The Cross-Bridge Level, Edward Debold
Edward P. Debold
The depression in force and/or velocity associated with muscular fatigue can be the result of a failure at any level, from the initial events in the motor cortex of the brain to the formation of an actomyosin cross-bridge in the muscle cell. Since all the force and motion generated by muscle ultimately derives from the cyclical interaction of actin and myosin, researchers have focused heavily on the impact of the accumulation of intracellular metabolites [e.g., Pi, H+ and adenosine diphoshphate (ADP)] on the function these contractile proteins. At saturating Ca++ levels, elevated Pi appears to be the primary cause for …
Macondo Crude Oil From The Deepwater Horizon Oil Spill Disrupts Specific Developmental Processes During Zebrafish Embryogenesis, T Yvanka De Soysa, Allison Ulrich, Timo Friedrich, Danielle Pite, Shannon L. Compton, Deborah Ok, Rebecca L. Bernardos, Gerald B. Downes, Shizuka Hsieh, Rachael Stein, M Caterina Lagdameo, Katherine Halvorsen, Lydia-Rose Kesich, Michael Jf Barresi
Macondo Crude Oil From The Deepwater Horizon Oil Spill Disrupts Specific Developmental Processes During Zebrafish Embryogenesis, T Yvanka De Soysa, Allison Ulrich, Timo Friedrich, Danielle Pite, Shannon L. Compton, Deborah Ok, Rebecca L. Bernardos, Gerald B. Downes, Shizuka Hsieh, Rachael Stein, M Caterina Lagdameo, Katherine Halvorsen, Lydia-Rose Kesich, Michael Jf Barresi
Gerald B. Downes
Background: The Deepwater Horizon disaster was the largest marine oil spill in history, and total vertical exposure of oil to the water column suggests it could impact an enormous diversity of ecosystems. The most vulnerable organisms are those encountering these pollutants during their early life stages. Water-soluble components of crude oil and specific polycyclic aromatic hydrocarbons have been shown to cause defects in cardiovascular and craniofacial development in a variety of teleost species, but the developmental origins of these defects have yet to be determined. We have adopted zebrafish, Danio rerio, as a model to test whether water accumulated fractions …
Expression Of Human Amyloid Precursor Protein In The Skeletal Muscles Of Drosophila Results In Age- And Activity-Dependent Muscle Weakness, Lawrence M. Schwartz, Chul Kim, Sapeckshita Srivastava, Marian Rice, Tanja A. Godenschwege, Brooke Bentley, Saranya Ravi, Shuang Shao, Ig T. Woodard
Expression Of Human Amyloid Precursor Protein In The Skeletal Muscles Of Drosophila Results In Age- And Activity-Dependent Muscle Weakness, Lawrence M. Schwartz, Chul Kim, Sapeckshita Srivastava, Marian Rice, Tanja A. Godenschwege, Brooke Bentley, Saranya Ravi, Shuang Shao, Ig T. Woodard
Lawrence M. Schwartz
Background One of the hallmarks of Alzheimer's disease, and several other degenerative disorders such as Inclusion Body Myositis, is the abnormal accumulation of amyloid precursor protein (APP) and its proteolytic amyloid peptides. To better understand the pathological consequences of inappropriate APP expression on developing tissues, we generated transgenic flies that express wild-type human APP in the skeletal muscles, and then performed anatomical, electrophysiological, and behavioral analysis of the adults. Results We observed that neither muscle development nor animal longevity was compromised in these transgenic animals. However, human APP expressing adults developed age-dependent defects in both climbing and flying. We could …