Life Sciences Commons^™

Lost In Translation, Daniel Pena

Master's Projects and Capstones

At the conclusion of a patient’s hospitalization the Registered Nurse (RN) will review all discharge instructions in the patients room in their preferred language. Plan time for the discharge and facilitate a calm quiet environment, such as the patient’s room with the door closed, if possible. Get the discharge instructions printed out in their preferred language and a set for yourself in English would be best so you are able to review the instructions line by line with them. When the patients medical team, such as but not limited to, medical doctors, pharmacists, physical therapists, and social work have completed …

Prevention Of Childhood Obesity And Diabetes, Karen Carig

Master's Projects and Capstones

One of the public health concerns that have been on the rise is childhood obesity and diabetes. The National Health and Nutrition Examination Survey indicate that approximately one-third of children in the United States are overweight or obese with 17% meeting criteria for obesity (Pulgaron and Delamater, 2014). This crisis exists nationally and internationally which can effect children in the following ways: physically, socially, psychologically and mentally. Although, genetics also play a role in these diseases, environmental factors, lifestyle preferences and cultural environmental play have a major influence. My internship with the Food Education Project covers a better understanding to …

The Role Of Orphan Nuclear Receptor Dax-1 (Nr0b1) In Human Breast Cancer Cells: Expression, Proliferation And Metastasis, Erin Dishington

Master's Theses

The orphan nuclear hormone receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita on the X Chromosome, gene 1) plays an important role in the development of adrenal and gonadal tissues and functions as a global negative-regulator of steroidogenesis. In addition, it is known to be involved in several diseases including some cancers. Herein, we describe our examination of the role of DAX-1 in breast cancer, specifically its influence on proliferation and metastasis and its expression during progressive stages of disease. In an effort to understand how DAX-1 influences breast cancer cell proliferation and metastasis, we used MCF7 breast cancer …

Rethinking Urban Green Infrastructure As A Means To Promote Avian Conservation, Allen Lau

Master's Projects and Capstones

There is an under-recognized potential for cities to use urban green infrastructure to contribute to avian biodiversity conservation. At the global scale, climate change and growing urbanization are primary global drivers leading to decline and homogenization in world bird populations. Birds are fundamental and intricate species in ecosystems, and even in urban areas, act as indicator and regulator species contributing to healthy ecosystem function. While many cities have recognized the economic and social benefits associated with green spaces, such as the vast benefits ecosystem services provide to the urban dweller, the use of green spaces to concurrently contribute to avian …

A Comparison Of Wildlife Monitoring Techniques In Riparian Ecosystems Of The Western United States, Shelan Zuhdi

Master's Projects and Capstones

Many riparian restoration projects in the western United States have not implemented monitoring plans. This lack of wildlife monitoring has resulted in a loss riparian ecosystem services and missed opportunities to conserve them. Data collected from wildlife monitoring assists researchers, policymakers, and stakeholders in efficiently allocating time and resources to improve the effectiveness of resource management. This paper discusses the level of feasibility and practicality as a sum of the benefits, limitations, and financial costs for each of the following mammal and avian monitoring methods: wildlife camera trapping, GPS devices, mark-recapture, fecal DNA surveying, circular plot point counts, mist-net transects …

Understanding The Complex Relationships Between Climate, Vegetation, And Foraging Behavior Of A Climate-Sensitive Alpine Mammal In Order To Explain Patterns Of Persistence, Evan Cole

Master's Projects and Capstones

Mountain ecosystems offer substantial ecosystem services but are highly sensitive to climate change. The American pika (Ochotona princeps) serves as an indicator species of climate change and a model organism for studying its impacts on mountain mammals. Certain aspects of plant community composition and structure can function as predictors of pika distribution, but understanding the links between climate, forage quality, and foraging behavior is necessary to identify the mediating mechanism. Pika foraging pressure help shape the local plant community, which can confound modeling efforts and must be considered when evaluating the influence of vegetation on pika persistence. Plant …

Dax-1 Gene Expression Regulation In Prostate Cancer Cells Through The Activation Of Androgen Receptors, Ryan Jann, Roxxana Beltran

Creative Activity and Research Day - CARD

The nuclear hormone receptor DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is associated with the development and progression of prostate cancer within human males. Previous studies on DAX-1 have suggested a repression of steroidogenesis, indicating an inverse correlation between DAX-1 and steroidogenic gene expressions. To further understand the role of DAX-1 in tumor growth and development, experimentation was performed on Androgen Receptor (AR) sensitive and insensitive prostate cancer cell lines. Analysis of the different gene expression patterns of prostate cancer cell lines (including a CRISPR DAX-1 negative cell line) under separate treatment conditions, provides …

Unboxing Cluster Heatmaps, Sophie J. Engle, S. Whalen, Alark Joshi, K. Pollard

Computer Science

Background: Cluster heatmaps are commonly used in biology and related fields to reveal hierarchical clusters in data matrices. This visualization technique has high data density and reveal clusters better than unordered heatmaps alone. However, cluster heatmaps have known issues making them both time consuming to use and prone to error. We hypothesize that visualization techniques without the rigid grid constraint of cluster heatmaps will perform better at clustering-related tasks.

Results: We developed an approach to “unbox” the heatmap values and embed them directly in the hierarchical clustering results, allowing us to use standard hierarchical visualization techniques as alternatives …

Obstacles To Preventing Obesity In Children Aged 2 To 5 Years: Latino Mothers’ And Fathers’ Experiences And Perceptions Of Their Urban Environments, Carlos Penilla, Jeanne M. Tschann, Emma V. Sanchez-Vaznaugh, Elena Flores, Emily J. Ozer

School of Education Faculty Research

Background

The prevalence of obesity among Latino children is alarmingly high, when compared to non-Latino White children. Low-income Latino parents living in urban areas, even if they are well-educated, face obstacles that shape familial health behaviors. This study used qualitative methods to explore parents’ experiences in providing meals and opportunities to play to their children aged 2 to 5 years. In contrast to most prior studies, this study examined perceptions of familial behaviors among both mothers and fathers.

Methods

An ecological framework for exploring the associations of parental feeding behaviors and children’s weight informed this study. An interview guide was …

Effect Of Human Cytomegalovirus (Hcmv) Us27 On Cxcr4 Receptor Internalization Measured By Fluorogen-Activating Protein (Fap) Biosensors, J. M. Boeck, Juliet Spencer

Biology Faculty Publications

Human cytomegalovirus (HCMV) is a widespread pathogen and a member of the Herpesviridae family. HCMV has a large genome that encodes many genes that are non-essential for virus replication but instead play roles in manipulation of the host immune environment. One of these is the US27 gene, which encodes a protein with homology to the chemokine receptor family of G protein-coupled receptors (GPCRs). The US27 protein has no known chemokine ligands but can modulate the signaling activity of host receptor CXCR4. We investigated the mechanism for enhanced CXCR4 signaling in the presence of US27 using a novel biosensor system comprised …

Human Cytomegalovirus Interleukin-10 Enhances Matrigel Invasion Of Mda-Mb-231 Breast Cancer Cells, Cendy Valle Oseguera, Juliet Spencer

Biology Faculty Publications

Background: While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. The HCMV protein cmvIL-10 is a potent suppressor of immune function that has also been shown to promote proliferation and migration of breast cancer cells. In this study, the impact of cmvIL-10 on tumor cell invasion through a simulated basement membrane was investigated.

Results: MDA-MB-231 breast cancer cells exhibited invasion through a matrigel layer that was significantly …