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Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Characterizing The Range Shifts Of Two Peromyscus Species In Maine, Molly Bennett
Characterizing The Range Shifts Of Two Peromyscus Species In Maine, Molly Bennett
Honors College
In a changing climate, two species of mice in Maine (Peromyscus maniculatus and Peromyscus leucopus) are currently undergoing range shifts. The objective of my thesis is to determine the historical and current range of each species within the state of Maine. I used two approaches. I assembled ear biopsies collected this summer in Acadia National Park and throughout the state by the Gardner and Levesque labs to genotype the mice as either P. maniculatus or P. leucopus. Additionally, I summarized research that denotes where the two species were historically present around the state. These species are functionally impossible to tell …
The Affective Disturbance Of Ethanol Withdrawal On C57bl/6j And C57bl/6nj Mice, Eric L. Levasseur
The Affective Disturbance Of Ethanol Withdrawal On C57bl/6j And C57bl/6nj Mice, Eric L. Levasseur
Honors College
The C57BL/6 (B6) mouse is the most commonly used inbred mouse strain in biomedical research. While the B6 mouse originated at The Jackson Laboratory, a number of separate breeding colonies are now maintained at various sites, resulting in genetic drift that has led to the emergence of both genotypic and phenotypic differences among these colonies. Two distinct substrains of B6 mice, C57BL/6J (B6J) and C57BL/6NJ (B6N), have been shown to differ on several addiction-related phenotypes, such as ethanol preference and locomotor responses to psychostimulants. Therefore, the aim of this study was to assess possible differences in depression- and anxiety-like behaviors …
An Analysis Of Neurogenesis In A Mouse Model Of Chemotherapy Related Cognitive Impairment, Maxwell A. Hennings
An Analysis Of Neurogenesis In A Mouse Model Of Chemotherapy Related Cognitive Impairment, Maxwell A. Hennings
Electronic Theses and Dissertations
Cancer patients treated with adjuvant chemotherapy often experience cognitive decline following treatment. This phenomenon, often dubbed “chemo brain” or “chemo fog” is usually temporary, but for a subset of survivors, these cognitive impairments can be long-lasting (>10 years) and negatively affect patients’ quality of life, career performance, and social fulfillment. While it is unclear what neurobiological mechanisms underlie chemotherapy related cognitive impairment, the majority of the animal literature has focused on adult neurogenesis. One process important for neurogenesis is the proliferation of new neurons within the dentate gyrus of the hippocampus. It is evident that many chemotherapy agents can …
Microglial Activation Immediately After Ethanol Withdrawal And 1 Week After Ethanol Withdrawal In Female C3h Mice, Sarah Holbrook
Microglial Activation Immediately After Ethanol Withdrawal And 1 Week After Ethanol Withdrawal In Female C3h Mice, Sarah Holbrook
Honors College
Alcohol abuse is the fourth leading cause of preventable death in the United States (National Institute on Alcohol Abuse and Alcoholism [NIAAA], 2016). Alcohol affects us on a molecular, biological, and even societal level. Liver damage, cancer, and drunk driving accidents are only a few adverse consequences of alcohol abuse. Studies have also shown that alcohol abuse can damage the brain, in part by activating the central nervous system’s immune system, leading to inflammation and demyelination. This damage may lead to alcohol-related psychiatric disorders, motor impairment, and cognitive disabilities. Studies have also shown that females tend to exhibit more damage …