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Full-Text Articles in Life Sciences

Biomechanical Analysis Of The Wrist Arthroplasty In Rheumatoid Arthritis: A Finite Element Analysis, Bajuri Mn, Abdul Kadir Mr, Murali Mr, Kamarul T Jan 2013

Biomechanical Analysis Of The Wrist Arthroplasty In Rheumatoid Arthritis: A Finite Element Analysis, Bajuri Mn, Abdul Kadir Mr, Murali Mr, Kamarul T

Murali Malliga Raman

The total replacement of wrists affected by rheumatoid arthritis (RA) has had mixed outcomes in terms of failure rates. This study was therefore conducted to analyse the biomechanics of wrist arthroplasty using recently reported implants that have shown encouraging results with the aim of providing some insights for the future development of wrist implants. A model of a healthy wrist was developed using computed tomography images from a healthy volunteer. An RA model was simulated based on all ten general characteristics of the disease. The ReMotion ™ total wrist system was then modelled to simulate total wrist arthroplasty (TWA). Finite …


A Comparative Study On Morphochemical Properties And Osteogenic Cell Differentiation Within Bone Graft And Coral Graft Culture Systems., Puvaneswary S, Balaji Raghavendran Hr, Ibrahim Ns, Murali Mr, Merican Am, Kamarul T Jan 2013

A Comparative Study On Morphochemical Properties And Osteogenic Cell Differentiation Within Bone Graft And Coral Graft Culture Systems., Puvaneswary S, Balaji Raghavendran Hr, Ibrahim Ns, Murali Mr, Merican Am, Kamarul T

Murali Malliga Raman

The objective of this study was to compare the morphological and chemical composition of bone graft (BG) and coral graft (CG) as well as their osteogenic differentiation potential using rabbit mesenchymal stem cells (rMSCs) in vitro. SEM analysis of BG and CG revealed that the pores in these grafts were interconnected, and their micro-CT confirmed pore sizes in the range of 107-315 µm and 103-514 µm with a total porosity of 92% and 94%, respectively. EDS analysis indicated that the level of calcium in CG was relatively higher than that in BG. FTIR of BG and CG confirmed the presence …


Characterization And Antibacterial Properties Of Stable Silver Substituted Hydroxyapatite Nanoparticles Synthesized Through Surfactant Assisted Microwave Process., Iqbal N, Abdul Kadir Mr, Nik Malekb Nan, Mahmooda Nhb, Murali Mr, Kamarul T Jan 2013

Characterization And Antibacterial Properties Of Stable Silver Substituted Hydroxyapatite Nanoparticles Synthesized Through Surfactant Assisted Microwave Process., Iqbal N, Abdul Kadir Mr, Nik Malekb Nan, Mahmooda Nhb, Murali Mr, Kamarul T

Murali Malliga Raman

The present study reports a relatively simple method for the synthesis of stable silver substituted hydroxyapatite nanoparticles with controlled morphology and particle size. In order to achieve this, CTAB is included as a surfactant in the microwave refluxing process (600 W for 7 min). The nanoparticles produced with different silver ion concentrations (0.05, 0.1 and 0.2 wt%) were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscope (FESEM), energy dispersive X-ray (EDX) and Brunauer–Emmett–Teller (BET) analysis. XRD and FTIR analyses reveal that the Ag-HA nanoparticles were phase pure at 1000 °C. FESEM images showed …


Pva-Chitosan Composite Hydrogel Versus Alginate Beads As A Potential Mesenchymal Stem Cell Carrier For The Treatment Of Focal Cartilage Defects: An In Vivo Study Using Rabbits, Dashtdar H, Murali Mr, Abbas Aa, Suhaeb Am, Selvaratnam L, Tay Lx, Kamarul T Jan 2013

Pva-Chitosan Composite Hydrogel Versus Alginate Beads As A Potential Mesenchymal Stem Cell Carrier For The Treatment Of Focal Cartilage Defects: An In Vivo Study Using Rabbits, Dashtdar H, Murali Mr, Abbas Aa, Suhaeb Am, Selvaratnam L, Tay Lx, Kamarul T

Murali Malliga Raman

PURPOSE: To investigate whether mesenchymal stem cells (MSCs) seeded in novel polyvinyl alcohol (PVA)-chitosan composite hydrogel can provide comparable or even further improve cartilage repair outcomes as compared to previously established alginate-transplanted models. METHODS: Medial femoral condyle defect was created in both knees of twenty-four mature New Zealand white rabbits, and the animals were divided into four groups containing six animals each. After 3 weeks, the right knees were transplanted with PVA-chitosan-MSC, PVA-chitosan scaffold alone, alginate-MSC construct or alginate alone. The left knee was kept as untreated control. Animals were killed at the end of 6 months after transplantation, and …


The Use Of X-Shaped Cross-Link In Posterior Spinal Constructs Improves Stability In Thoracolumbar Burst Fracture: A Finite Element Analysis, Alizadeh M, Kadir Mr, Fadhli Mm, Fallahiarezoodar A, Azmi B, Murali Malliga Raman, Kamarul T Jan 2013

The Use Of X-Shaped Cross-Link In Posterior Spinal Constructs Improves Stability In Thoracolumbar Burst Fracture: A Finite Element Analysis, Alizadeh M, Kadir Mr, Fadhli Mm, Fallahiarezoodar A, Azmi B, Murali Malliga Raman, Kamarul T

Murali Malliga Raman

Posterior instrumentation is a common fixation method used to treat thoracolumbar burst fractures. However, the role of different cross-link configurations in improving fixation stability in these fractures has not been established. A 3D finite element model of T11-L3 was used to investigate the biomechanical behavior of short (2 level) and long (4 level) segmental spine pedicle screw fixation with various cross-links to treat a hypothetical L1 vertebra burst fracture. Three types of cross-link configurations with an applied moment of 7.5 Nm and 200 N axial force were evaluated. The long construct was stiffer than the short construct irrespective of whether …