Life Sciences Commons^™

Santa Clara Magazine, Volume 63 Number 2, Fall 2022 [Print Issue 62:2], Santa Clara University

Santa Clara Magazine

14 - AFTER THE CANNONBALL What does it mean to wrestle with your own human limitations and vulnerability as you follow the footsteps of a saint? Hung Pham, S.J.

18 - GROWING When I was little, there seemed to be this nondescript era of life, a foggy “someday,” when becoming an adult just happened. Nikhita Panjnani ’24.

20 - HOW IT STARTED, HOW IT'S GOING For decades, the internet has shaped the way we communicate, but two years of being extremely online hit fast forward on its real-world impact. Matt Morgan.

26 - NURTURING NATURE A story in two stories: …

Santa Clara Magazine, Volume 63 Number 1, Summer 2022, Santa Clara University

Santa Clara Magazine

16 - SHARED DREAMS Meet incoming University President Julie Sullivan, the first layperson and woman selected to lead SCU. Leslie Griffy

20 - BD KNOWS BEST Discovering who you really are, being grateful, and dinosaurs with BD Wong. Lauren Loftus.

22 - SWEPT AWAY Being homeless in Silicon Valley is particularly deadly. One professor explores why so many die in a land of such excess. Leslie Griffy .

28 - ON THE OUTSIDE A first-person account of being wrongly convicted, as told by Arturo Jimenez.

30 - BOOKED AND BUSY The secret behind the Hollywood success of so many Bronco …

Santa Clara Magazine, Volume 62 Number 2, Fall 2021, Santa Clara University

Santa Clara Magazine

18 - WE ARE THE CHAMPIONS The pandemic stole an entire year of games from them. But this team still won it all. Written by Harold Gutmann. Illustrated by Liam Eisenberg.

26 - INFORMED BY STRUGGLE. How hardship forged a sense of gratitude in SCU finance professor Meir Statman and his wife, Navah. Written by Deborah Lohse.

30 - TWEETING GOOD There’s a Bronco who finds hope, God, and cat pictures online. We talk with @padreSJ. Interviewed by Leslie Griffy. Illustrated by Kyle Hilton.

34 - SIGNALS FROM A CHANGING PLANET. The imprints of humans on the environment spell a …

Santa Clara Magazine, Volume 62 Number 1, Spring 2021 [Print Issue V.61:1], Santa Clara University

Santa Clara Magazine

14 - VALUE PROPOSITION With more people going to college than ever before, how do we calculate the worth of a college degree? Lauren Loftus.

22 - HUMANITY IN THE HUMOR Santa Clara Magazine sat down with Assistance Professor Danielle Morgan to explore how laughter can be lifesaving—and life affirming. Leslie Griffy.

26 - TOMORROWLAND So really, what happens next? We chat with experts about how the pandemic could change our world as we know it. Leslie Griffy and Tracy Seipel.

32 - A BREAK Explore what you see when you step away from it all—and discover some flighty friends …

Santa Clara Magazine, Volume 61 Number 3, Fall 2020 [Print Issue V.61:2], Santa Clara University

Santa Clara Magazine

16 - THE GIFT Is sacrifice, given willingly and with love, what makes us human? Leslie Griffy.

20 - NOT A MOMENT, BUT A MOVEMENT From protests in Benson in 1969 to a multi-decade movement called Unity, students of color have consistently pushed SCU to progress. Matt Morgan.

28 - ON BEING BETTER Discover the ways we can better support each other, particularly as white people seek to become allies to people of color. Lauren Loftus.

32 - THE SACRIFICIAL TWEET Social media missteps are costly, perhaps now more than ever. Just what are we willing to give up to …

Uv Radiation Increases Flavonoid Protection But Decreases Reproduction In Silene Littorea, José Carlos Del Valle, Mª Luisa Buide, Justen B. Whittall, Fernando Valladares, Eduardo Narbona

Biology

Plants respond to changes in ultraviolet (UV) radiation both morphologically and physiologically. Among the variety of plant UV-responses, the synthesis of UV-absorbing flavonoids constitutes an effective non-enzymatic mechanism to mitigate photoinhibitory and photooxidative damage caused by UV stress, either reducing the penetration of incident UV radiation or acting as quenchers of reactive oxygen species (ROS). In this study, we designed a UV-exclusion experiment to investigate the effects of UV radiation in Silene littorea. We spectrophotometrically quantified concentrations of both anthocyanins and UV-absorbing phenolic compounds in petals, calyces, leaves and stems. Furthermore, we analyzed the UV effect on the photosynthetic …

Genome Skimming And Microsatellite Analysis Reveal Contrasting Patterns Of Genetic Diversity In A Rare Sandhill Endemic (Erysimum Teretifolium, Brassicaceae), José Carlos Del Valle, Julie A. Herman, Justen B. Whittall

Biology

Barriers between islands often inhibit gene flow creating patterns of isolation by distance. In island species, the majority of genetic diversity should be distributed among isolated populations. However, a self-incompatible mating system leads to higher genetic variation within populations and very little between-population subdivision. We examine these two contrasting predictions in Erysimum teretifolium, a rare self-incompatible plant endemic to island-like sandhill habitats in Santa Cruz County, California. We used genome skimming and nuclear microsatellites to assess the distribution of genetic diversity within and among eight of the 13 remaining populations. Phylogenetic analyses of the chloroplast genomes revealed a deep …

Unexpected Predicted Length Variation For The Coding Sequence Of The Sleep Related Gene, Bhlhe41 In Gorilla Amidst Strong Purifying Selection Across Mammals, Krishna Unadkat, Justen B. Whittall

Biology

There is a molecular basis for many sleep patterns and disorders involving circadian clock genes. In humans, “short-sleeper” behavior has been linked to specific amino acid substitutions in BHLHE41 (DEC2), yet little is known about variation at these sites and across this gene in mammals. We compare BHLHE41 coding sequences for 27 mammals. Approximately half of the coding sequence was invariable at the nucleotide level and close to three-quarters of the amino acid alignment was identical. No other mammals had the same “short-sleeper” amino acid substitutions previously described from humans. Phylogenetic analyses based on the nucleotides of the coding sequence …

Santa Clara Magazine, Volume 61 Number 2, Spring 2020 [Print Issue V.61:1], Santa Clara University

Santa Clara Magazine

14 - THE UPSTART How Michael Mondavi ’66 helped get Napa on the wine map. By Ron Hansen.

18 - OF WOMEN AND MEN Emeritus professors dish on their research into wine and women. By Tracy Seipel.

22 - A SIGN OF LIGHT A Jesuit priest finds meaning on death row. By George Williams, S.J.

26 - FIRE AND WINE As the climate changes, what’s next for wine remains murky. By Tracy Seipel.

Sustainable, Alginate-Based Sensor For Detection Of Escherichia Coli In Human Breast Milk, Nicholas Kikuchi, Margaret May, Matthew Zweber, Jerard Madamba, Craig M. Stephens, Unyoung Kim, Maryam Mobed-Miremadi

Bioengineering

There are no existing affordable diagnostics for sensitive, rapid, and on-site detection of pathogens in milk. To this end, an on-site colorimetric-based sustainable assay has been developed and optimized using an L₁₆ (5⁴) Taguchi design to obtain results in hours without PCR amplification. To determine the level of Escherichia coli (E. coli) contamination, after induction with 150 µL of breast milk, the B-Per bacterial protein extraction kit was added to a solution containing an alginate-based microcapsule assay. Within this 3 mm spherical novel sensor design, X-Gal (5-Bromo-4-Chloro-3-Indolyl β-_D-Galactopyranoside) was entrapped at a concentration of 2 …

Whole Plastome Sequencing Within Silene Section Psammophilae Reveals Mainland Hybridization And Divergence With The Balearic Island Populations, José Carlos Del Valle, Inés Casimiro-Soriguer, Mᵃ Luisa Buide, Eduardo Narbona, Justen B. Whittall

Biology

Reconstructing the phylogenetic relationships within Caryophyllaceae tribe Sileneae has been obscured by hybridization and incomplete lineage sorting. Silene is the largest genus in the Caryophyllaceae, and unraveling its evolutionary history has been particularly challenging. In order to infer the phylogenetic relationships among the five species in Silene section Psammophilae, we have performed a genome skimming approach to acquire the complete plastid genome (cpDNA), nuclear ribosomal cistron (nrDNA), and partial mitochondrial genome (mtDNA). We have included 26 populations, representing the range of each species' distribution. This section includes five morphologically similar species endemic to the Iberian Peninsula and Balearic Islands …

Stability Of Petal Color Polymorphism: The Significance Of Anthocyanin Accumulation In Photosynthetic Tissues, José Carlos Del Valle, Cristina Alcalde-Eon, Mª Teresa Escribano-Bailón, Mª Luisa Buide, Justen B. Whittall, Eduardo Narbona

Biology

Background: Anthocyanins are the primary source of colour in flowers and also accumulate in vegetative tissues, where they have multiple protective roles traditionally attributed to early compounds of the metabolic pathway (flavonols, flavones, etc.). Petal-specific loss of anthocyanins in petals allows plants to escape from the negative pleiotropic effects of flavonoid and anthocyanins loss in vegetative organs, where they perform a plethora of essential functions. Herein, we investigate the degree of pleiotropy at the biochemical scale in a pink-white flower colour polymorphism in the shore campion, Silene littorea. We report the frequencies of pink and white individuals across 21 populations …

Santa Clara Magazine, Volume 60 Number 3, Summer 2019, Santa Clara University

Santa Clara Magazine

16 - PROTECTING THE HEART To grow the campus, we must care for the thing unchanging at its center—its Mission. Take a journey through the restoration of Mission Santa Clara de Asís. By Lander Eicholzer ’19.

22 - A LOBBY FOR JUSTICE What do you do when it is impossible for the innocent to prove their innocence? Change the law. The Northern California Innocence Project teamed up with state lawmakers and others to do just that. By Deborah Lohse.

26 - FINDING CENTER Outgoing Frank Sinatra Chair in the Performing Arts Taye Diggs reflects on celebrating who are you, where …

Santa Clara Magazine, Volume 60 Number 4, Summer 2019, Santa Clara University

Santa Clara Magazine

16 - PROTECTING THE HEART To grow the campus, we must care for the thing unchanging at its center—its Mission. Take a journey through the restoration of Mission Santa Clara de Asís. By Lander Eicholzer ’19.

22 - A LOBBY FOR JUSTICE What do you do when it is impossible for the innocent to prove their innocence? Change the law. The Northern California Innocence Project teamed up with state lawmakers and others to do just that. By Deborah Lohse.

26 - FINDING CENTER Outgoing Frank Sinatra Chair in the Performing Arts Taye Diggs reflects on celebrating who are you, where …

The Santa Clara, 2019-05-16, Santa Clara University

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The Santa Clara, 2019-05-09, Santa Clara University

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The Santa Clara, 2019-05-02, Santa Clara University

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The Santa Clara, 2019-04-25, Santa Clara University

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The Santa Clara, 2019-04-18, Santa Clara University

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The Santa Clara, 2019-04-11, Santa Clara University

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The Santa Clara, 2019-04-04, Santa Clara University

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Santa Clara Magazine, Volume 60 Number 2, Spring 2019 [Print Issue V. 60:1], Santa Clara University

Santa Clara Magazine

28 - TECHNOLOGY, WONDER & US We’re at the epicenter of the biggest ecosystem of information exchange in history. How do we ensure tech fosters human flourishing? By Dorian Llywelyn, S.J. Illustrations by Derek Brahney.

36 - QUERY RESULTS What questions should we be asking about ethics and AI? Here are six. By Irina Raicu J.D. ’09. Illustrations by Paul Blow.

40 - A CURIOUS CASE If you want to innovate for the world, you need the room to do it. Sanjiv Das and a tale of machine learning, mortgages, and mistaken identity. By Deborah Lohse. Illustrations by Ellen Weinstein. …

The Santa Clara, 2019-02-28, Santa Clara University

The Santa Clara

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The Santa Clara, 2019-02-14, Santa Clara University

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The Santa Clara, 2019-02-07, Santa Clara University

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The Santa Clara, 2019-01-24, Santa Clara University

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The Santa Clara, 2019-02-21, Santa Clara University

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The Santa Clara, 2019-01-17, Santa Clara University

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The Santthe Santa Clara, 2019-01-10, Santa Clara University

The Santa Clara

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Santa Clara Magazine, Volume 61 Number 1, Winter 2019, Santa Clara University

Santa Clara Magazine

14 - IN THE BEGINNING An interview with Santa Clara University President Kevin O’Brien, S.J. on what's next and noticing what we swim in. Matt Morgan

22 - ADAM, EVE, AND THE APPLE If making—and appreciating—art makes us human, what happens when we get help making a masterpiece from something unhuman? Lauren Loftus.

28 - BEDROCK When faced with tough decisions, Santa Clara values stand as good guides, says Leon Panetta ’60, J.D. ’63. Leslie Griffy.