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A Novel Cardiac Muscle-Derived Biomaterial Reduces Dyskinesia And Postinfarct Left Ventricular Remodeling In A Mouse Model Of Myocardial Infarction, Daniel M. O'Connor, Nivedita K. Naresh, Bryan A. Piras, Yaqin Xu, Robert S. Smith, Roy C. Ogle

Medical Diagnostics & Translational Sciences Faculty Publications

Extracellular matrix (ECM) degradation after myocardial infarction (MI) leaves the myocardium structurally weakened and, as a result, susceptible to early infarct zone dyskinesia and left ventricular (LV) remodeling. While various cellular and biomaterial preparations have been transplanted into the infarct zone in hopes of improving post-MI LV remodeling, an allogeneic cardiac muscle-derived ECM extract has yet to be developed and tested in the setting of reperfused MI. We sought to determine the effects of injecting a novel cardiac muscle-derived ECM into the infarct zone on early dyskinesia and LV remodeling in a mouse model of MI. Cardiac muscle ECM was …