Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biochemistry, Biophysics, and Structural Biology (4)
- Biochemistry (3)
- Physical Sciences and Mathematics (3)
- Chemistry (2)
- Medicine and Health Sciences (2)
-
- Architecture (1)
- Arts and Humanities (1)
- Business (1)
- Education (1)
- Engineering (1)
- Horticulture (1)
- Medical Genetics (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Microbiology (1)
- Molecular Biology (1)
- Neurology (1)
- Neuroscience and Neurobiology (1)
- Plant Sciences (1)
- Social and Behavioral Sciences (1)
- Keyword
-
- Bulbs (1)
- Catalysis (1)
- Conference program (1)
- Electron spin resonance spectroscopy (1)
- Elizabeth Lawrence (1)
-
- Enzyme kinetics (1)
- Enzymes (1)
- Formates (1)
- Gardening (1)
- Genetic strains (1)
- Glycine receptors (1)
- Homology (1)
- Immunohistochemistry (1)
- Interdisciplinary (1)
- Ion channels (1)
- Manganese (1)
- Molecular dynamics (1)
- Mutations (1)
- Myxococcus xanthus (1)
- Negative regulation (1)
- Nervous system diseases (1)
- Nutrient and storage proteins (1)
- Oxalates (1)
- Phenotype (1)
- Phenotypes (1)
- Posters (1)
- Presentations (1)
- Protein domains (1)
- Protein structure networks (1)
- Protons (1)
- Publication
- Publication Type
Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Distinct Phenotypes In Zebrafish Models Of Human Startle Disease, Lisa R. Ganser, Qing Yan, Victoria M. James, Robert Kozol, Maya Topf, Robert J. Harvey, Julia E. Dallman
Distinct Phenotypes In Zebrafish Models Of Human Startle Disease, Lisa R. Ganser, Qing Yan, Victoria M. James, Robert Kozol, Maya Topf, Robert J. Harvey, Julia E. Dallman
Faculty Articles
Startle disease is an inherited neurological disorder that causes affected individuals to suffer noise- or touch-induced non-epileptic seizures, excessive muscle stiffness and neonatal apnea episodes. Mutations known to cause startle disease have been identified in glycine receptor subunit (GLRA1 and GLRB) and glycine transporter (SLC6A5) genes, which serve essential functions at glycinergic synapses. Despite the significant successes in identifying startle disease mutations, many idiopathic cases remain unresolved. Exome sequencing in these individuals will identify new candidate genes. To validate these candidate disease genes, zebrafish is an ideal choice due to rapid knockdown strategies, accessible embryonic stages, and stereotyped behaviors. The …
Peregrination Of The Selectivity Filter Delineates The Pore Of The Human Voltage-Gated Proton Channel Hhv1, Deri Morgan, Boris Musset, Kethika Kulleperuma, Susan M. E. Smith, Sindhu Rajan, Vladimir V. Cherny, Régis Pomès, Thomas E. Decoursey
Peregrination Of The Selectivity Filter Delineates The Pore Of The Human Voltage-Gated Proton Channel Hhv1, Deri Morgan, Boris Musset, Kethika Kulleperuma, Susan M. E. Smith, Sindhu Rajan, Vladimir V. Cherny, Régis Pomès, Thomas E. Decoursey
Faculty Articles
Extraordinary selectivity is crucial to all proton-conducting molecules, including the human voltage-gated proton channel (hHv1), because the proton concentration is >106 times lower than that of other cations. Here we use "selectivity filter scanning" to elucidate the molecular requirements for proton-specific conduction in hHv1. Asp112, in the middle of the S1 transmembrane helix, is an essential part of the selectivity filter in wild-type (WT) channels. After neutralizing Asp112 by mutating it to Ala (D112A), we introduced Asp at each position along S1 from 108 to 118, searching for "second site suppressor" activity. …
Protein Similarity Networks Reveal Relationships Among Sequence, Structure, And Function Within The Cupin Superfamily, Richard Uberto, Ellen W. Moomaw
Protein Similarity Networks Reveal Relationships Among Sequence, Structure, And Function Within The Cupin Superfamily, Richard Uberto, Ellen W. Moomaw
Faculty Articles
The cupin superfamily is extremely diverse and includes catalytically inactive seed storage proteins, sugar-binding metal-independent epimerases, and metal-dependent enzymes possessing dioxygenase, decarboxylase, and other activities. Although numerous proteins of this superfamily have been structurally characterized, the functions of many of them have not been experimentally determined. We report the first use of protein similarity networks (PSNs) to visualize trends of sequence and structure in order to make functional inferences in this remarkably diverse superfamily. PSNs provide a way to visualize relatedness of structure and sequence among a given set of proteins. Structure- and sequence-based clustering of cupin members reflects functional …
2013 - The Eighteenth Annual Symposium Of Student Scholars
2013 - The Eighteenth Annual Symposium Of Student Scholars
Symposium of Student Scholars Program Books
The full program book from the Eighteenth Annual Symposium of Student Scholars, held on April 25, 2013. Includes abstracts from the presentations and posters.
Book Review - The Little Bulbs: A Tale Of Two Gardens, Karin J. Bennedsen
Book Review - The Little Bulbs: A Tale Of Two Gardens, Karin J. Bennedsen
Georgia Library Quarterly
No abstract provided.
Kinetic And Spectroscopic Studies Of Bicupin Oxalate Oxidase And Putative Active Site Mutants, Ellen W. Moomaw, Eric Hoffer, Patricia Moussatche, John C. Salerno
Kinetic And Spectroscopic Studies Of Bicupin Oxalate Oxidase And Putative Active Site Mutants, Ellen W. Moomaw, Eric Hoffer, Patricia Moussatche, John C. Salerno
Faculty Articles
Ceriporiopsis subvermispora oxalate oxidase (CsOxOx) is the first bicupin enzyme identified that catalyzes manganese-dependent oxidation of oxalate. In previous work, we have shown that the dominant contribution to catalysis comes from the monoprotonated form of oxalate binding to a form of the enzyme in which an active site carboxylic acid residue must be unprotonated. CsOxOx shares greatest sequence homology with bicupin microbial oxalate decarboxylases (OxDC) and the 241-244DASN region of the N-terminal Mn binding domain of CsOxOx is analogous to the lid region of OxDC that has been shown to determine reaction specificity. We have prepared a series of CsOxOx …
Characterization Of Myxococcus Xanthus Mazf And Implications For A New Point Of Regulation, Tye O. Boynton, Jonathan L. Mcmurry, Lawrence J. Shimkets
Characterization Of Myxococcus Xanthus Mazf And Implications For A New Point Of Regulation, Tye O. Boynton, Jonathan L. Mcmurry, Lawrence J. Shimkets
Faculty Articles
During development, Myxococcus xanthus cells undergo programmed cell death (PCD) whereby 80% of vegetative cells die. Previously, the MazF RNA interferase has been implicated in this role. Recently, it was shown that deletion of the mazF gene does not eliminate PCD in wild-type strain DK1622 as originally seen in DZF1. To clarify the role of MazF, recombinant enzyme was characterized using a highly sensitive assay in the presence and absence of the proposed antitoxin MrpC. In contrast to previous reports that MrpC inhibits MazF activity, the hydrolysis rate was enhanced in a concentration-dependent manner with MrpC or MrpC2, an N-terminally …