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Full-Text Articles in Life Sciences

Improved Efficiency And Sensitivity Analysis Of 3-D Agent-Based Model For Pain-Related Neural Activity In The Amygdala, Kayla Kraeuter, Carley Reith, Benedict J. Kolber, Rachael Miller Neilan Jul 2024

Improved Efficiency And Sensitivity Analysis Of 3-D Agent-Based Model For Pain-Related Neural Activity In The Amygdala, Kayla Kraeuter, Carley Reith, Benedict J. Kolber, Rachael Miller Neilan

Spora: A Journal of Biomathematics

Neuropathic pain is caused by nerve injury and involves brain areas such as the central nucleus of the amygdala (CeA). We developed the first 3-D agent-based model (ABM) of neuropathic pain-related neurons in the CeA using NetLogo3D. The execution time of a single ABM simulation using realistic parameters (e.g., 13,000 neurons and 22,000+ neural connections) is an important factor in the model’s usability. In this paper, we describe our efforts to improve the computational efficiency of our 3-D ABM, which resulted in a 28% reduction in execution time on average for a typical simulation. With this upgraded model, we performed …


Analysis Of An Agent-Based Model For Predicting The Behavior Of Bighead Carp (Hypophthalmichthys Nobilis) Under The Influence Of Acoustic Deterrence, Craig Garzella, Joseph Gaudy, Karl R. B. Schmitt, Arezu Mansuri Feb 2020

Analysis Of An Agent-Based Model For Predicting The Behavior Of Bighead Carp (Hypophthalmichthys Nobilis) Under The Influence Of Acoustic Deterrence, Craig Garzella, Joseph Gaudy, Karl R. B. Schmitt, Arezu Mansuri

Spora: A Journal of Biomathematics

Bighead carp (Hypophthalmichthys nobilis) are an invasive, voracious, highly fecund species threatening the ecological integrity of the Great Lakes. This agent-based model and analysis explore bighead carp behavior in response to acoustic deterrence in an effort to discover properties that increase likelihood of deterrence system failure. Results indicate the most significant (p < 0.05) influences on barrier failure are the quantity of detritus and plankton behind the barrier, total number of bighead carp successfully deterred by the barrier, and number of native fishes freely moving throughout the simulation. Quantity of resources behind the barrier influence bighead carp to penetrate when populations are resource deprived. When native fish populations are low, an accumulation of phytoplankton can occur, increasing the likelihood of an algal bloom occurrence. Findings of this simulation suggest successful implementation with proper maintenance of an acoustic deterrence system has potential of abating the threat of bighead carp on ecological integrity of the Great Lakes.