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- Alternative polyadenylation (1)
- Bird (1)
- Collision induced dissociation (1)
- Data alignment (1)
- Dynamic time warping (1)
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- Feather loss (1)
- Flapping performance (1)
- Gas-phase basicity (1)
- Gas-phase ion energetics (1)
- HERG (1)
- Ion mobility spectrometry (IMS) (1)
- Keel bone damage (1)
- Lipids (1)
- Long QT syndrome (1)
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- Structures for lossless ion manipulations (SLIM) (1)
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- Whole-body kinematics (1)
- Wing kinematics (1)
Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Domestic Egg-Laying Hens, Gallus Gallus Domesticus, Do Not Modulate Flapping Flight Performance In Response To Wing Condition, Brianna M. León, Bret W. Tobalske, Neila Ben Sassi, Renée Garant, Donald R. Powers, Alexandra Harlander-Matauschek
Domestic Egg-Laying Hens, Gallus Gallus Domesticus, Do Not Modulate Flapping Flight Performance In Response To Wing Condition, Brianna M. León, Bret W. Tobalske, Neila Ben Sassi, Renée Garant, Donald R. Powers, Alexandra Harlander-Matauschek
Faculty Publications - Department of Biological & Molecular Science
Wild birds modulate wing and whole-body kinematics to adjust their flight patterns and trajectories when wing loading increases flight power requirements. Domestic chickens (Gallus gallus domesticus) in backyards and farms exhibit feather loss, naturally high wing loading, and limited flight capabilities. Yet, housing chickens in aviaries requires birds to navigate three-dimensional spaces to access resources. To understand the impact of feather loss on laying hens’ flight capabilities, we symmetrically clipped the primary and secondary feathers before measuring wing and whole-body kinematics during descent from a 1.5 m platform. We expected birds to compensate for increased wing loading by increasing wingbeat …
Regulation Of Kv11.1 Isoform Expression By Polyadenylate Binding Protein Nuclear 1, Matthew R. Stump, Rachel T. Nguyen, Rachel H. Drgastin, Delaney Search, Quiming Gong, Zhengfeng Zhou
Regulation Of Kv11.1 Isoform Expression By Polyadenylate Binding Protein Nuclear 1, Matthew R. Stump, Rachel T. Nguyen, Rachel H. Drgastin, Delaney Search, Quiming Gong, Zhengfeng Zhou
Faculty Publications - Department of Biological & Molecular Science
The Kv11.1 voltage-gated potassium channel, encoded by the KCNH2 gene, conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative polyadenylation to generate two C-terminal Kv11.1 isoforms in the heart. Utilization of a poly(A) signal in exon 15 produces the full-length, functional Kv11.1a isoform, while intron 9 polyadenylation generates the C-terminally truncated, nonfunctional Kv11.1a-USO isoform. The relative expression of Kv11.1a and Kv11.1a-USO isoforms plays an important role in the regulation of Kv11.1 channel function. In this study, we tested the hypothesis that the RNA polyadenylate binding protein nuclear 1 (PABPN1) interacts with a unique 22 nt …
Measurement And Theory Of Gas-Phase Ion Mobility Shifts Resulting From Isotopomer Mass Distribution Changes, Christopher P. Harrilal, Viraj D. Gandhi, Gabe Nagy, Xi Chen, Michael G. Buchanan, Roza Wojcik, Christopher R. Conant, Micah T. Donor, Yehia M. Ibrahim, Sandilya V. B. Garimella, Richard D. Smith, Carlos Larriba-Andaluz
Measurement And Theory Of Gas-Phase Ion Mobility Shifts Resulting From Isotopomer Mass Distribution Changes, Christopher P. Harrilal, Viraj D. Gandhi, Gabe Nagy, Xi Chen, Michael G. Buchanan, Roza Wojcik, Christopher R. Conant, Micah T. Donor, Yehia M. Ibrahim, Sandilya V. B. Garimella, Richard D. Smith, Carlos Larriba-Andaluz
Faculty Publications - Department of Biological & Molecular Science
The unanticipated discovery of recent ultra-high-resolution ion mobility spectrometry (IMS) measurements revealing that isotopomers—compounds that differ only in the isotopic substitution sites—can be separated has raised questions as to the physical basis for their separation. A study comparing IMS separations for two isotopomer sets in conjunction with theory and simulations accounting for ion rotational effects provides the first-ever prediction of rotation-mediated shifts. The simulations produce observable mobility shifts due to differences in gas−ion collision frequency and translational-to-rotational energy transfer. These differences can be attributed to distinct changes in the moment of inertia and center of mass between isotopomers. The simulations …
Combined Effects Of Experimentally Elevated Cort And Predation Threat On Exploratory And Foraging Behavior Of Desmognathus Ochrophaeus, Aaron M. Sullivan, Ian E. Kratzer, Seanna C. Jobe, Jacquelyn L. Lewis
Combined Effects Of Experimentally Elevated Cort And Predation Threat On Exploratory And Foraging Behavior Of Desmognathus Ochrophaeus, Aaron M. Sullivan, Ian E. Kratzer, Seanna C. Jobe, Jacquelyn L. Lewis
Faculty Publications - Department of Biological & Molecular Science
Amphibian responses to stress are generally mediated through glucocorticoids produced by the hypothalamic–pituitary–interrenal axis. Chronic elevation of glucocorticoids can result in delayed wound healing and growth, but less is known about its influence on behavioral responses to predators. We examined the effect of acute and chronic CORT elevation on exploratory and foraging behaviors of Allegheny Mountain Dusky Salamanders (Desmognathus ochrophaeus) exposed to kairomones from a predatory snake. We established ‘No CORT,' ‘Acute CORT,' and ‘Chronic CORT’ conditions during an 18-d preparation phase by varying salamander exposure to an exogenous source of CORT (0.51 mg/mL) delivered via cutaneous patch. …
Lipid Head Group Adduction To Soluble Proteins Follows Gas-Phase Basicity Predictions: Dissociation Barriers And Charge Abstraction, Micah T. Donor, Jesse W. Wilson, Samantha O. Shepherd, James S. Prell
Lipid Head Group Adduction To Soluble Proteins Follows Gas-Phase Basicity Predictions: Dissociation Barriers And Charge Abstraction, Micah T. Donor, Jesse W. Wilson, Samantha O. Shepherd, James S. Prell
Faculty Publications - Department of Biological & Molecular Science
Native mass spectrometry analysis of membrane proteins has yielded many useful insights in recent years with respect to membrane protein-lipid interactions, including identifying specific interactions and even measuring binding affinities based on observed abundances of lipid-bound ions after collision-induced dissociation (CID). However, the behavior of non-covalent complexes subjected to extensive CID can in principle be affected by numerous factors related gas- subjected to extensive CID can in principle be affected by numerous factors related gas- subjected to extensive CID can in principle be affected by numerous factors related gas-subjected to extensive CID can in principle be affected by numerous factors …
Dynamic Time-Warping Correction For Shifts In Ultrahigh Resolving Power Ion Mobility Spectrometry And Structures For Lossless Ion Manipulations, Adam L. Hollerbach, Christopher R. Conant, Gabe Nagy, Matthew E. Monroe, Khushboo Gupta, Micah T. Donor, Cameron M. Giberson, Sandilya V. B. Garimella, Richard D. Smith, Yehia M. Ibrahim
Dynamic Time-Warping Correction For Shifts In Ultrahigh Resolving Power Ion Mobility Spectrometry And Structures For Lossless Ion Manipulations, Adam L. Hollerbach, Christopher R. Conant, Gabe Nagy, Matthew E. Monroe, Khushboo Gupta, Micah T. Donor, Cameron M. Giberson, Sandilya V. B. Garimella, Richard D. Smith, Yehia M. Ibrahim
Faculty Publications - Department of Biological & Molecular Science
Detection of arrival time shifts between ion mobility spectrometry (IMS) separations can limit achievable resolving power (Rp), particularly when multiple separations are summed or averaged, as commonly practiced in IMS. Such variations can be apparent in higher Rp measurements and are particularly evident in long path length traveling wave structures for lossless ion manipulations (SLIM) IMS due to their typically much longer separation times. Here, we explore data processing approaches employing single value alignment (SVA) and nonlinear dynamic time warping (DTW) to correct for variations between IMS separations, such as due to pressure fluctuations, to enable more effective spectrum summation …