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Articles 91 - 106 of 106
Full-Text Articles in Life Sciences
Locus Coeruleus And Hippocampal Tyrosine Hydroxylase Levels In A Pressure-Overload Model Of Heart Disease, Luke A. Johnson
Locus Coeruleus And Hippocampal Tyrosine Hydroxylase Levels In A Pressure-Overload Model Of Heart Disease, Luke A. Johnson
Undergraduate Honors Theses
Studies have indicated that approximately 30% of people with heart disease experience major depressive disorder (MDD). Despite strong clinical evidence of a link between the two diseases, the neurobiological processes involved in the relationship are poorly understood. A growing number of studies are revealing similar neuroanatomical and neurochemical abnormalities resulting from both depression and heart disease. The locus coeruleus (LC) is a group of neurons in the pons that synthesize and release norepinephrine, and that is known to play a significant role in depression pathobiology. For example, there is evidence that tyrosine hydroxylase (TH) is elevated in the LC in …
Acute Exercise And Its Effect On Cognitive Performance In Sleep Deprived Individuals: A Review Of Literature., Jennifer Nicole Miller
Acute Exercise And Its Effect On Cognitive Performance In Sleep Deprived Individuals: A Review Of Literature., Jennifer Nicole Miller
Undergraduate Honors Theses
This literature review observes seven different studies that researched the effects of exercise on some measure of cognitive or psychological performance when sleep deprived. The purpose of this review is to consolidate the results of various exercise protocols on the effects of sleep deprivation to make a general conclusion regarding the effect on cognition. This will give insight into the future of research regarding how exercise may combat performance decrements seen when sleep deprived. There are several inconsistencies among current research concerning exercise and sleep deprivation; a standard needs to be created so the results of these studies can be …
Localization And Expression Of Gfrα2 Receptors In Neonatal And Adolescent Mouse Heart., Bryan Gunter
Localization And Expression Of Gfrα2 Receptors In Neonatal And Adolescent Mouse Heart., Bryan Gunter
Undergraduate Honors Theses
Neurturin (NRTN), a member of the glial cell-line derived neurotrophic factor(GDNF) family, is required in the development of parasympathetic cholinergic neurons. It signals through binding to a glycosyl-phophatidyl inositol (GPI)-linked receptor, GDNF family receptor α2 (GFRα2), which couples to Ret tyrosine kinase. Studies of NRTN knockout mice have shown that NRTN is essential for normal cholinergic innervation of the heart, but the precise role of NRTN remains unknown. For NRTN to evoke a biological response, GFRα2 must be localized to the surface of target neurons. The aim of this study was to determine the expression and localization of GFRα2 at …
Effects Of Microgravity On Mucin Production In The Urinary Bladder In Mice., Brandon Farmer
Effects Of Microgravity On Mucin Production In The Urinary Bladder In Mice., Brandon Farmer
Undergraduate Honors Theses
The effects of the microgravity of spaceflight are largely unexplored with regard to biological tissues. One particular area of interest is the possible effects microgravity could have on the production of mucins. To determine the possible effects of microgravity on mucin production in the urinary bladder, we examined the transitional epithelium of the urinary bladder from female mice that were flown on the space shuttle Endeavour for 12 days in August, 2007. The flight tissue was compared to tissues from two control groups of animals, ground control and baseline. This study utilized three sets of female mice, with each set …
The Relationship Of Strength And Body Composition To Vertical Jump Ability In Division 1 Female Volleyball Players., Alyssa Shedlarski
The Relationship Of Strength And Body Composition To Vertical Jump Ability In Division 1 Female Volleyball Players., Alyssa Shedlarski
Undergraduate Honors Theses
Jump ability is important in volleyball; therefore analysis of factors that influence jump performance is necessary to ensure maximal jump ability. Purpose: To analyze how strength characteristics associated with jumping are affected by percent body fat, lean body mass and free fat mass. Methods: Data from eleven female NCAA DI volleyball players as part of an ongoing athlete monitoring program collected from 2007-2010 was analyzed. Data was separated into weakest and strongest based on isometric peak force allometrically scaled. In all cases the weakest data corresponded to testing during the athletes first year at ETSU. Body composition was measured using …
The Effect Of Ultraviolet Light On Cell Viability, Dna Damage And Repair In Hutchinson-Gilford Progeria Syndrome And Bj Fibroblasts., Mckayla Johnson
The Effect Of Ultraviolet Light On Cell Viability, Dna Damage And Repair In Hutchinson-Gilford Progeria Syndrome And Bj Fibroblasts., Mckayla Johnson
Undergraduate Honors Theses
Patients of Hutchinson-Gilford Progeria Syndrome (HGPS) display a rate of aging up to ten times that of normal human populations. It might be expected that HGPS cells would have a decreased ability to repair DNA damage through the cell cycle as compared to normal cells such as those of the BJ cell line since DNA damage accumulation is a hallmark phenotype of aging. On earth, we are exposed to far more ultraviolet-B (UV-B, 280-315 nm) and UV-A (315-400 nm) than UV-C (100-280 nm) radiation, since the latter is filtered-out by the atmospheric ozone layer. The relative sensitivity of prematurely aging …
The Effects Of The Vitamin E Isomers Gamma Tocopherol And Gamma Tocotrienol On The Nfkb Pathway In The Pc-3 Cell Line., Brittney Rudder
The Effects Of The Vitamin E Isomers Gamma Tocopherol And Gamma Tocotrienol On The Nfkb Pathway In The Pc-3 Cell Line., Brittney Rudder
Undergraduate Honors Theses
Regions along the Mediterranean and Southern Asia have lower prostate cancer incidence compared to the rest of the world. It has been hypothesized that one of the potential contributing factors for this low incidence includes a higher intake of vitamin E (tocopherols and tocotrienols). This study examines the potential of gamma tocopherol (GT) and gamma tocotrienol (GT3) to reduce prostate cancer proliferation by examining their effects on the NFκB pathway. NFκB is known to inhibit apoptosis in cancer cells. Our data shows that both GT and GT3 are capable of down regulation of NFκB precursors and up regulation of Caspase …
Impacts Of Goat Browsing And Disease On Lilium Grayi, Gray's Lily, On Roan Mountain., Joseph Powell
Impacts Of Goat Browsing And Disease On Lilium Grayi, Gray's Lily, On Roan Mountain., Joseph Powell
Undergraduate Honors Theses
The flora of southern Appalachian high elevation balds has strong representation of northern disjuncts and regional endemics. Among the endemics, the showy Lilium grayi (Gray’s Lily), is most noteworthy for its historical significance and for a high public profile. As bald vegetation changes in response to human and natural environmental shifts, active bald management has been implemented on public lands. Among managed balds, the Roan Mountain massif supports a large population of L. grayi. The purpose of this study was to describe the demography of adult plants, compare browsed and non-browsed plots, and determine the extent to which disease …
Role Of Stress In The Onset Of Diabetes Mellitus In Mice., Lindsey Brianne Mcamis
Role Of Stress In The Onset Of Diabetes Mellitus In Mice., Lindsey Brianne Mcamis
Undergraduate Honors Theses
This study investigated the effects of stress on the onset of chemically-induced diabetes mellitus in mice. Sixty male ICR mice were randomly divided into 6 groups of 10 mice. A factorial arrangement of 2 factors (streptozotocin (STZ) and stress) was used to produce 6 treatments. Three levels of STZ (0, 25 and 50 mg/kg bodyweight) and 2 levels of stress (stress and no-stress) were used. Stressed groups were exposed to restraint stress 6 hours daily for 18 days. Mice bodyweight, feed consumption and blood glucose levels were recorded regularly during the study period. At the end of the study period, …
Skeletal Development In Oviparous And Viviparous Populations Of Saiphos Equalis., Melia Baker
Skeletal Development In Oviparous And Viviparous Populations Of Saiphos Equalis., Melia Baker
Undergraduate Honors Theses
This study examines ossification at different embryonic stages to develop a pattern of ossification and to look at differences between oviparous and viviparous populations of the same species.
Effects Of Vitamin E Isomer, Gamma Tocotrienol (Gt3), At Inhibiting Cell Growth And Inducing Apoptosis In Colon Cancer Cell Line Hct-116., Havya Dave
Undergraduate Honors Theses
Colorectal cancer is the third most prominent cancer world-wide and it is the second leading cause of cancer deaths in the United States. Many dietary components affect the risk of developing colorectal cancer, such as Vitamin E. Of the eight isomers of Vitamin E, four have a tocotrienol structure. Tocotrienols are found at highest concentrations in palm oil, which is ingested more in areas of Asia where the incidence of colorectal cancer is the lowest, suggesting a role of tocotrienols in the prevention of colorectal cancer. The metabolism of Arachidonic acid pathway produces a host of pro-inflammatory metabolites either by …
An Economic Impact Analysis For The 2nd Annual Bluegrass, Old-Time Music And Dance Festival In The Village Of Stone Mountain, Georgia., Kevin A. Lane
An Economic Impact Analysis For The 2nd Annual Bluegrass, Old-Time Music And Dance Festival In The Village Of Stone Mountain, Georgia., Kevin A. Lane
Undergraduate Honors Theses
Festivals in the Appalachian region may provide a substantial economic impact for host communities. Regionally unique themes like Bluegrass and Old-Time music are substantial draw factors for potential visitors. This paper uses information collected at a small Appalachian themed music festival to project what the economic impact of hosting such an event is. Demographic information and an analysis of the festival visitor drawing area will further project the economic activity affected by the event.
Calcium Provision In A Placentotrophic Lizard: Structural Differentiation Reflects Functional Specialization., Haley K. Stinnett
Calcium Provision In A Placentotrophic Lizard: Structural Differentiation Reflects Functional Specialization., Haley K. Stinnett
Undergraduate Honors Theses
Viviparity (live birth) and placentation have evolved in more than 100 lineages of squamate reptiles. However, highly placentotrophic species in which embryos receive the majority of nutrients for development via maternal transport across a placenta are rare. Pseudemoia pagenstecheri is a viviparous Australian scincid lizard with extensive placental transfer of nutrients. For example, 90% of neonate calcium is received via placental transfer. This species has a regionally differentiated chorioallantoic placenta distinguished by an elliptical-shaped region, the placentome. The placentome is characterized by hypertrophied uterine and embryonic epithelial cells supported by dense vascular networks. The remainder of the chorioallantoic placenta is …
A Profile Of Rural Southern Appalachian Hiv Patients: Vamc Versus Com., Lauren Brooks
A Profile Of Rural Southern Appalachian Hiv Patients: Vamc Versus Com., Lauren Brooks
Undergraduate Honors Theses
Although the AIDS epidemic in America began approximately three decades ago, much remains to be learned about the epidemiology of human immunodeficiency virus (HIV) infections in rural America. This study compared profiles of HIV patients at the James H. Quillen Veterans Affairs Medical Center (VAMC) in Mountain Home, TN to those seen at a university-based community HIV care clinic (COM) in Johnson City, TN.
Expression Of Human Neutrophil Elastase In K. Lactis., Haley M. Klimecki
Expression Of Human Neutrophil Elastase In K. Lactis., Haley M. Klimecki
Undergraduate Honors Theses
Human neutrophils are the most abundant type of white blood cell and provide the body with a line of defense against foreign, infectious microorganisms. Contained within the azurophilic granules in the cytoplasm of neutrophils are three serine proteases, Human Neutrophil Elastase, Cathepsin G, and Protease 3. Once a foreign bacterium is engulfed by white blood cells, these enzymes attack and degrade the invading body, thus killing it (Reeves et al., 2002). The focus of this research is centered on the production of one of the serine proteases, human neutrophil elastase (HNE), and while the importance of HNE can be seen, …
Forest Change And Balsam Woolly Adelgig Infestation In High Elevation Forests Of Mt. Mitchell, North Carolina., Laura Lusk
Undergraduate Honors Theses
The Black Mountain range of western North Carolina supports some of the most extensive, but threatened high elevation forests in the southern Appalachians. Of particular note, the insect pathogen, balsam woolly adelgid (Adelges piceae Ratzeburg) has been present on Mt. Mitchell for over fifty years. In anticipation of potential changes in forest composition, vegetation surveys were first conducted in 1966 on nine one-acre plots near the summit of Mt. Mitchell. These plots were re-surveyed in 1978, 1985 and 2002. The purpose of this study was to re-census those plots and use those data to analyze long-term trends in forest …