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Investigating The Role Of Epibiotic Bacteria In Defense Against Chytridiomycosis In The Green Frog, Lithobates Clamitans, Sarah Nalven
Investigating The Role Of Epibiotic Bacteria In Defense Against Chytridiomycosis In The Green Frog, Lithobates Clamitans, Sarah Nalven
Honors Theses
Amphibian populations have been declining for several decades, in part due to the emerging fungal skin disease, chytridiomycosis, caused by the chytrid fungus Batrachochytrium dendrobatidis (Bd). Chytridiomycosis has caused extinctions and extirpations in many parts of the world, but its influence varies across species, populations, and individuals. The Green Frog (Lithobates clamitans), which inhabits the eastern half of the United States, seems capable of sustaining Bd infections without experiencing die-offs. It is possible that the Green Frog's epibiotic bacteria are contributing to its defense against Bd as the epibiotic bacteria of several amphibian species are known to play …
Prenatal Choline Supplementation And Mk-801 Toxicity: Protecting Memory And Preventing Neurodegeneration, Chelsea Nickerson
Prenatal Choline Supplementation And Mk-801 Toxicity: Protecting Memory And Preventing Neurodegeneration, Chelsea Nickerson
Honors Theses
Choline is essential to the development and function of the central nervous system. Supplemental choline is neuroprotective against a variety of insults, including neurotoxins like dizocilpine (MK-801). MK-801 is an NMDA receptor antagonist that is frequently used in rodent models of psychological disorders. At low doses, it causes cognitive impairments, and at higher doses it induces motor deficits, anhedonia, and neuronal degeneration. The primary goals of the present study were to investigate whether prenatal choline supplementation protects against the cognitive impairments, motor deficits, and neuropathologies that are precipitated by MK-801 administration in adulthood. Adult male Sprague Dawley rats were fed …