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Full-Text Articles in Life Sciences
Designing Tuftsin Conjugate For Directing Antimicrobial Ionophores To Macrophages, Sokhna Seck, Zeenat Razvi
Designing Tuftsin Conjugate For Directing Antimicrobial Ionophores To Macrophages, Sokhna Seck, Zeenat Razvi
Undergraduate Research Posters 2015
For all microorganisms, acquisition of metal ions is essential for survival in the environment or their infected host. Metal ions are required in many biological processes as cofactors for proteins or structural elements for enzymes. These ions play a role in chemotaxis, phosphorylation, transport of sugars and proteins, and initiation of DNA replication, among other things. It is critical for bacteria to ensure that metal uptake and availability meet its physiological needs; too little can impede these important biological processes, while too much can be toxic leading to radical formation which can cause damage to proteins and cell structures (Porcheron, …
Nitrosylation Of S100a8/ A9 Protein Complex By Inducible Nitric Oxide Synthase, Kia Smith
Nitrosylation Of S100a8/ A9 Protein Complex By Inducible Nitric Oxide Synthase, Kia Smith
Undergraduate Research Posters 2015
How does the body fight infection? What causes inflammation? These are only a few questions that have been asked by many doctors across the globe. One thing that is known for certain about infection is that there is a particular sub-group of enzymes called NOS’s (eNOS, nNOS and iNOS) that produce Nitric Oxide (NO), a molecule radical capable of oxidizing proteins and alter their function. In our study we focus on inducible Nitric Oxide Synthase (iNOS). NOS’s are comprised of oxidase and reductase domains liked by Camodulin (CAM), a polypeptide linker. According to prior studies and SEM photographs, inducible Nitric …
Statistical Analysis Of Dasi Questionnaire And Modeling The Prediction Of Heart Failure Risk In Patients, Christian Negron
Statistical Analysis Of Dasi Questionnaire And Modeling The Prediction Of Heart Failure Risk In Patients, Christian Negron
Undergraduate Research Posters 2015
9,880 patients were asked to complete the DASI questionnaire along with other questions to assess the predictability of heart failure risk. In this paper we attempt to reduce the amount of questions asked by hierarchical clustering of the question responses to determine if there is a change in the predictability of heart failure risk in patients. The data was modeled using Cox hazards multiple regression and validated through ROC and AUC. Our validation models show there is no difference between the usage of 12 and 6 DASI questions, therefore improving the simplicity of the questionnaire. Abbreviations: DASI, Duke Activity Status …
Optimizing The Design And Potency Of Diterpenic Acid Derivatives To Improve Cell Membrane Permeability And Hsp27 Targeting Characteristics, Aicha Quamine
Undergraduate Research Posters 2015
Heat shock protein 27 (Hsp27) acts as a protective protein allowing it to play an integral role in aiding cancer cell resistance. Stress-induced Hsp 27 overexpression aids in the stabilization of partially denatured proteins to establish protein refolding resulting in thermotolerance, inhibition of apoptosis, cytoprotection, etc. As a result of rapid proliferation and general instability, cancer cells exhibit increased dependency on the support of Hsp 27 and it’s chaperone proteins, therefore generating an ideal target for anticancer therapy. Copalic acid, a clerodane diterpenoid, has already been confirmed in effective chaperone inhibition and antiproliferative synergistic effect. We hypothesize that by optimizing …
Dual Stimuli Response Frequency And Stimulus Choice Of The African Clawed Frog, Xenopus Laevis, When Presented With Two Stimuli, Mingo Rolince, Heidi Pignolet, Alexa Hoy
Dual Stimuli Response Frequency And Stimulus Choice Of The African Clawed Frog, Xenopus Laevis, When Presented With Two Stimuli, Mingo Rolince, Heidi Pignolet, Alexa Hoy
Undergraduate Research Posters 2015
This preliminary study examines responses of African Clawed Frogs to simultaneous presentation of two stimuli. Frogs were tested in a round arena with water 4 cm deep. Four stimulus rods driven via computer-controlled stepper motors were concealed in a screen suspended above the water. These rods could present a lateral line stimulus, a visual stimulus, or a combination of both. Overall, reactions and no reactions were evenly distributed--51.1% and 48.9%, respectively. Frogs responded more frequently to rostral than caudal stimuli (chi-squared 20.8, df=11, p < 0.04). Frogs reacted more to stimuli between -90° and 90°. Turn angle depended linearly on stimulus angle (e.g., Turn angle = 0.44 + 0.64 x Stimulus angle; pslope < 0.0001; R2adj = 69.5%). (The distributions of stimulus angles appear slightly skewed as often the same stimulus rod was retested after the frog responded and partially oriented towards it, prompting a second test with smaller angles.) Two stimuli did not elicit more responses than one stimuli (P=0.25). The frogs’ choice of stimulus depended primarily on stimulus proximity and angle, not stimulus type. When presented with two stimuli, the frog chose the nearer stimulus and the more rostral stimulus (p < 0.0001). The largest factor in predicting the frog’s choice of stimuli seems to be the linear distance from the stimuli to the frog.
Enhancement Of Solar Energy Conversion In Bio-Derived Cells Via Side Selective Modification Of Photosystem I, Uchechukwu Obiako, Evan Gizzie
Enhancement Of Solar Energy Conversion In Bio-Derived Cells Via Side Selective Modification Of Photosystem I, Uchechukwu Obiako, Evan Gizzie
Undergraduate Research Posters 2015
Deleterious effects of some methods used to harness energy from the environment today have garnered the exploration of safer and more reliable options, specifically solar energy conversion. Current solar cell technology has yielded quantum efficiencies commonly in the range of 10-20% but is limited by extensive processing methods, high cost, and need for rare materials. However, bio-derived solar cells containing Photosystem I (PSI) address these problems as PSI is highly abundant, very efficient, and low-cost. PSI acts as a biomolecular photodiode through rapid photoexcited charge separation, making it very promising for use as an integral element in solar cells. To …
Investigating Rhoptry Gene Conservation Between Plasmodium Yoelii And Plasmodium Falciparum Using The Polymerase Chain Reaction For Dna Amplification, Brooke Burkhalter
Investigating Rhoptry Gene Conservation Between Plasmodium Yoelii And Plasmodium Falciparum Using The Polymerase Chain Reaction For Dna Amplification, Brooke Burkhalter
Undergraduate Research Posters 2015
In order to obtain a tangible basis for vaccine targets, it is crucial to understand the role of proteins at the site of invasion. In previous study, 27 novel rhoptry proteins were identified by MudPIT analysis and immunoelectron microscopy. In this investigation, the conservation of rhoptry genes between Plasmodium yoelii and Plasmodium falciparum was assessed. From the previously identified rhoptry genes, 14 were investigated with the orthologues/paralogues of the Plasmodium falciparum, Plasmodium yoelii, Plasmodium chabaudi, and Plasmodium berghei. Also, primers designed for the 14 Plasmodium yoelli rhoptry genes were used to test DNA amplification with the PCR. Amplification of Plasmodium …
Cultural Differences In Coping And Depression Between Individuals Of Middle-Eastern And Non-Arab Backgrounds, Khadeja Najjar
Cultural Differences In Coping And Depression Between Individuals Of Middle-Eastern And Non-Arab Backgrounds, Khadeja Najjar
Undergraduate Research Posters 2015
The Middle Eastern (Arab) demographic is a growing, yet neglected cultural group in mental health research. While Arabs are more predisposed to depression than other ethnic groups in US, little is known about mechanisms that account for this risk. One set of mechanisms may be the use of ineffective (maladaptive) coping or insufficient use of effective (adaptive) coping responses, which are robust predictors of depression in US samples, but virtually unexamined in Arabs. Further, the effect of a coping is influenced by culture, which, for Arabs, may change as a function of acculturation. Thus, the present study aimed to examine …