Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Clemson University

2014

Discipline
Keyword
Publication
Publication Type

Articles 31 - 60 of 89

Full-Text Articles in Life Sciences

A Case Study In Watershed-Based Plan Development And Implementation For The May River Watershed In Bluffton, South Carolina, Kimberly W. Jones, Ronald Bullman Aug 2014

A Case Study In Watershed-Based Plan Development And Implementation For The May River Watershed In Bluffton, South Carolina, Kimberly W. Jones, Ronald Bullman

Journal of South Carolina Water Resources

The Town of Bluffton, South Carolina was a one square mile coastal village until it experienced exponential growth in the early 2000s, and today is approximately 54 square miles. Until this recent growth, few sources of possible impairments to water quality were recognized within the watershed, and even fewer within close proximity to the river itself. In 2007, the Town was told by the S.C. Department of Health and Environmental Control (SCDHEC) that fecal coliform levels in the May River headwaters were increasing and in 2009 the river received a shellfish harvesting classification down-grade. In response to this down-grade, the …


Long Bay Hypoxia Monitoring Consortium, Susan Libes, Michael Trapp, Scott Kindelberger, Danielle Doremus Aug 2014

Long Bay Hypoxia Monitoring Consortium, Susan Libes, Michael Trapp, Scott Kindelberger, Danielle Doremus

Journal of South Carolina Water Resources

In October 2011, the coastal municipalities of North Myrtle Beach, Myrtle Beach, Surfside, and Horry County signed a resolution, under the aegis of their Coastal Alliance of mayors, to develop and implement the Long Bay Hypoxia Monitoring Consortium. The goal of this consortium is to support monitoring and studies that further characterize hypoxia and its causes in Long Bay. The baseline data will enable assessments of water quality management efforts. Monitoring stations are to be maintained at three piers, Cherry Grove (NMB), Apache (Horry County), and Second Ave N. Pier (Myrtle Beach). Turbidity and chlorophyll sensors will be deployed at …


Green Infrastructure In Coastal Landscapes: Ecological Design, Hydrological Function, And Sustainable Land Use Guidance, Daniel R. Hitchcock, Anand D. Jayakaran, David L. White Aug 2014

Green Infrastructure In Coastal Landscapes: Ecological Design, Hydrological Function, And Sustainable Land Use Guidance, Daniel R. Hitchcock, Anand D. Jayakaran, David L. White

Journal of South Carolina Water Resources

Coastal landscape modification, specifically the conversion of forests to residential and commercial development, coupled with potential climate change impacts, could lead to irretrievable natural resource impairment. An assessment of existing resources (green infrastructure) and their benefits via ecosystem services provides useful guidance for resource protection to enhance community resilience. These landscape elements are complex within and between varying scales; therefore stakeholders need clear, relevant, comparable, and easily accessible information for effective decision-making.


South Carolina's Climate Report Card: Understanding South Carolina's Climate Trends And Variability, Hope Mizzell, Mark Malsick, Ivetta Abramyan Aug 2014

South Carolina's Climate Report Card: Understanding South Carolina's Climate Trends And Variability, Hope Mizzell, Mark Malsick, Ivetta Abramyan

Journal of South Carolina Water Resources

This study provides an overview of South Carolina’s climatic trends and variability over the last century. Most studies nationally have focused on large-scale temperature and precipitation trends, but examination of regional and local trends are needed to monitor the significance of the state’s climate signal and advance our understanding of the complex physical controls on the region’s climate. The behavior of several climatic elements since the 1900s were evaluated for 66 sites in South Carolina and bordering states to determine the variability of the system on annual, seasonal and decadal scales, including the use of threshold approaches to assess climate …


Gene Discovery And Differential Expression Analysis Of Humoral Immune Response Elements In Female Culicoides Sonorensis (Diptera: Ceratopogonidae), Naya Nayduch, Matthew B. Lee, Christopher Saski Aug 2014

Gene Discovery And Differential Expression Analysis Of Humoral Immune Response Elements In Female Culicoides Sonorensis (Diptera: Ceratopogonidae), Naya Nayduch, Matthew B. Lee, Christopher Saski

Publications

Female Culicoides sonorensis midges (Diptera: Ceratopogonidae) are vectors of pathogens that impact livestock and wildlife in the United States. Little is known about their biology on a molecular-genetic level, including components of their immune system. Because the insect immune response is involved with important processes such as gut microbial homeostasis and vector competence, our aims were to identify components of the midge innate immune system and examine their expression profiles in response to diet across time.


The Avian Thrombocyte Is A Specialized Immune Cell, Farzana Ferdous Aug 2014

The Avian Thrombocyte Is A Specialized Immune Cell, Farzana Ferdous

All Dissertations

Thrombocytes are the most abundant circulating cells next to red blood cells in avian blood. Avian thrombocytes are homologous in function to mammalian platelets. Avian thrombocytes and the mammalian platelet are widely recognized contributors to inflammatory responses upon stimulation with various microbial stimulants. However, some observed responses of the avian thrombocyte depart from a standardized model ascribed to innate cells. To help unravel the role of thrombocytes in innate immunity, and possibly adaptive immunity, first we examined the surface features of chicken thrombocytes. Chicken thrombocytes constitutively express transcripts for different Toll-like receptors (TLRs) that are crucial for the innate immune …


Evaluation Of A Mycorrhizal-Like Fungus, Piriformospora Indica, On Floriculture Crops, Allison Justice Aug 2014

Evaluation Of A Mycorrhizal-Like Fungus, Piriformospora Indica, On Floriculture Crops, Allison Justice

All Dissertations

Piriformospora indica is a fungal endophyte, often called an arbuscular mycorrhizal-like fungus, that has been shown to provide benefits to plant symbionts by increasing nutrient uptake, biomass production, flower number, and disease resistance in a wide range of plant hosts. Research was carried out to investigate the ability of P. indica to improve plant production in floriculture crops. The first objective was to determine the optimal environmental conditions for growing P. indica in pure culture. Environmental conditions were optimized to produce the maximum chlamydospores for inoculum preparation (Chapter 1). These findings were used in the remaining chapters to prepare inocula …


Antioxidant Effect Of Peach Skin Extracts From 13 Varieties Of South Carolina Grown Peaches, Yueyuan Zhang Aug 2014

Antioxidant Effect Of Peach Skin Extracts From 13 Varieties Of South Carolina Grown Peaches, Yueyuan Zhang

All Theses

South Carolina is the second largest peach producing state in the United States. Every year, large quantities of peaches do not meet the fresh peach standard and are discarded or used for further processing. The waste stream from discarded and processed peaches includes the skin and this could be recovered as a rich source of antioxidants. The objective of this research was to determine the antioxidant (phenolic) content and antioxidant capacity of peach skin from various peach varieties grown in South Carolina. Chapter 1 is a literature review which covers topics of oxidation in foods, mechanism of lipid oxidation, antioxidants …


Application Of Modern Statistical Tools To Solving Contemporary Economic Problems: Evaluation Of The Regional Agricultural Campaign Impact And The Usda Forecasting Efforts, Ran Xie Aug 2014

Application Of Modern Statistical Tools To Solving Contemporary Economic Problems: Evaluation Of The Regional Agricultural Campaign Impact And The Usda Forecasting Efforts, Ran Xie

All Dissertations

The research is comprised with three studies to implement statistical tools for examining two economic issues: the impact of a regional agricultural campaign on participating restaurants and efforts of U.S. Department of Agriculture (USDA) forecasting reports in agricultural commodity markets. The first study examined how various components of the Certified South Carolina campaign are valued by participating restaurants. A choice experiment was conducted to estimate the average willingness to pay (WTP) for each campaign component using a mixed logit model. Three existing campaign components--Labeling, Multimedia Advertising, and the 'Fresh on the Menu' program were found to have a significant positive …


Biology, Ecology, And Control Of Doveweed (Murdannia Nudiflora [L.] Brenan), Jeffrey Atkinson Aug 2014

Biology, Ecology, And Control Of Doveweed (Murdannia Nudiflora [L.] Brenan), Jeffrey Atkinson

All Dissertations

Doveweed (Murdannia nudiflora [L.] Brenan) is a summer annual in the Southeastern United States with an expanding geographic range. The light green color and texture of doveweed is problematic for turfgrass managers as it contrasts with the color and texture of desirable turfgrasses. Limited research is available concerning the biology, ecology, and herbicide control options for doveweed. Therefore, experiments were conducted to improve the understanding of how environmental conditions effect doveweed germination, how cultural practices and environmental resource availability effect doveweed growth and development, to identify pre- and postemergence herbicides with efficacy for doveweed control, and to improve the understanding …


Evaluation Of The Functional Capabilities Of Fins And Limbs For Moving On Land: Insights Into The Invasion Of Land By Tetrapods, Sandy Kawano Aug 2014

Evaluation Of The Functional Capabilities Of Fins And Limbs For Moving On Land: Insights Into The Invasion Of Land By Tetrapods, Sandy Kawano

All Dissertations

Transitions to novel habitats present different adaptive challenges, producing captivating examples of how functional innovations of the musculoskeletal system influence phenotypic divergence and adaptive radiations. One intriguing example is the transition from aquatic fishes to tetrapods. Recent technological advances and discoveries of critical fossils have catapulted our understanding on how fishes gave rise to terrestrial vertebrates. Considerable attention has been paid to legged locomotion on land, but given that the first tetrapods were aquatic, limbs did not evolve primarily for terrestriality. How, then, is the locomotor function of limbs different from fins? Extant amphibious fishes demonstrate that fins can be …


Growth Responses Of Genetically Improved Open Pollenated, Full-Sibling, And Clonal Loblolly Pine To The FlexstandTm Silvicultural System, Patrick Ma Aug 2014

Growth Responses Of Genetically Improved Open Pollenated, Full-Sibling, And Clonal Loblolly Pine To The FlexstandTm Silvicultural System, Patrick Ma

All Theses

ABSTRACT Loblolly pine (Pinus taeda) is often listed as the most commercially important timber species in the southeastern United States and is subject to genetic improvement via breeding programs to increase sawtimber yield, stem quality, and disease resistance. ArborGen has trademarked the FlexStandTM Silvicultural System (a method of interplanting rows of genetically improved trees with less expensive biomass trees) as a more economical solution to growing Loblolly pine. Two studies were conducted to in order to assess the FlexStandTM Silvicultural System. The first study assessed seedling mortality and growth of four different genetic combinations were assessed in the …


Use Of Unmanned Aerial Vehicles (Uav) For Urban Tree Inventories, Brian Ritter Aug 2014

Use Of Unmanned Aerial Vehicles (Uav) For Urban Tree Inventories, Brian Ritter

All Theses

In contrast to standard aerial imagery, unmanned aerial systems (UAS) utilize recent technological advances to provide an affordable alternative for imagery acquisition. Increased value can be realized through clarity and detail providing higher resolution (2-5 cm) over traditional products. Many natural resource disciplines such as urban forestry will benefit from UAS. Tree inventories for risk assessment, biodiversity, planning, and design can be efficiently achieved with the UAS. Recent advances in photogrammetric processing have proved automated methods for three dimensional rendering of aerial imagery. Point clouds can be generated from images providing additional benefits. Association of spatial locational information within the …


A Comparison Of Saponin And Tween 80 On The Solubility And The Degradation Enhancement Of Fluoranthene And The Influence Of Laccase On Fluoranthene Degradation, Stacia Ballew Aug 2014

A Comparison Of Saponin And Tween 80 On The Solubility And The Degradation Enhancement Of Fluoranthene And The Influence Of Laccase On Fluoranthene Degradation, Stacia Ballew

All Theses

The ubiquitous contamination of polycyclic aromatic hydrocarbons (PAHs) in the environment require an economical approach as well as effective remediation techniques in the removal of these contaminants. Through the use of more eco-friendly and economically available biosurfactants, such as saponin, there is a possibility they could prove to be more useful surfactants than conventional synthetic surfactants for the solubilization of fluoranthene (FLA). Enhanced solubility would potentially facilitate the increased degradation by S. paucimobilis EPA505. The addition of laccase produced by Pleurotus ostreatus, a white rot fungus that produces enzymes known to facilitate or assist in the degradation of fluoranthene (FLA), …


Is It Culturally Appropriate? Evaluation Efforts For Measuring The Cultural Appropriateness In Nutrition Education Programs Targeting The Hispanic Population, Andrea Aguilar Corrales Aug 2014

Is It Culturally Appropriate? Evaluation Efforts For Measuring The Cultural Appropriateness In Nutrition Education Programs Targeting The Hispanic Population, Andrea Aguilar Corrales

All Theses

Background: In the United States, nearly 70% of the population is overweight. The U.S. National Health and Nutrition Examination Survey says Hispanics have the second prevalence of obesity, thus, increasing the risk of heart disease, cancer, stroke and diabetes in the largest minority group in the U.S. (U.S. Census, 2010). This requires effective and culturally appropriate interventions to promote healthy lifestyles. (WHO, 2003). Objective: The purpose of this study was to design and pilot-test a culturally appropriate tool to assure the nutrition information provided to the Hispanic population is appropriate. Design: The research design consisted of a triangulation of methods …


The Effect Of Gender And Status Difference On Saturated Fat Content Of Entree Items Chosen By Elementary School-Aged Students, Annie Anderson Aug 2014

The Effect Of Gender And Status Difference On Saturated Fat Content Of Entree Items Chosen By Elementary School-Aged Students, Annie Anderson

All Theses

The purpose of this study was to examine participants in a National School Lunch Program (NSLP), and the effect of gender and/or participation in the NSLP on selection of high saturated fat content entrée items by the students. Nutrition information provided to parents often does not include a profile of the fats offered in school lunch items. This was true of this study's schools. However, new NSLP guidelines focus upon saturated and trans fat content in school lunches. The total kcal limit is less than 30% total fat, and saturated fat is less than or equal to 10% total kcal, …


Ecohydrological Function Of Lower Coastal Plain Bioretention Cells In South Carolina, Jessica Palazzolo Aug 2014

Ecohydrological Function Of Lower Coastal Plain Bioretention Cells In South Carolina, Jessica Palazzolo

All Theses

Flooding and stormwater control is a critical issue in coastal South Carolina because of shallow water table elevation, topography and rapid urbanization in the region. A best management practice (BMP) using low impact design (LID) principles known as a bioretention cell (BRC) is gaining popularity for stormwater management. Five BRCs in four landscape positions (well-drained uplands, tidal-proximal, poorly-drained-uplands, and floodplain) were instrumented for microclimate, soil moisture, and water table elevation for hydraulic efficiency and for water quality measurements. Three BRCs did not have an overflow outlets, one BRC (floodplain) employed an underdrain system, and one BRC (tidal proximal) had an …


Food, Nutrition, Culinary, And Packaging Science Undergraduate Research, Experiential Learning, And Product Development Focusing On Childhood Nutrition, Alexandra Weeks Aug 2014

Food, Nutrition, Culinary, And Packaging Science Undergraduate Research, Experiential Learning, And Product Development Focusing On Childhood Nutrition, Alexandra Weeks

All Theses

The objective of this research project was to develop a two-semester Applied Interdisciplinary Product Development (AIPD) course for sophomore students in the Food, Nutrition and Packaging Sciences (FNPS) department that would increase students’ confidence in skills pertaining to product development of food products and childhood nutrition, increase their sense of connection with the department, and would better prepare them to enter industry than students that did not participate in the course. A Subject Knowledge Assessment (SKA) was used to evaluate the mean difference value (MDV) of food science, nutrition, packaging science, and general product development knowledge gained through the AIPD …


South Atlantic Stream Fish Assemblages: Multi-Scale Structuring Factors, Trait Associations And Channelization, And Responses To Dam Removal, Cathy Marion Aug 2014

South Atlantic Stream Fish Assemblages: Multi-Scale Structuring Factors, Trait Associations And Channelization, And Responses To Dam Removal, Cathy Marion

All Dissertations

South Atlantic coastal plain wadeable streams are unique and understudied freshwater environments that provide crucial habitats for a wide range of aquatic taxa. In Chapter 1, we investigated patterns in fish assemblages across South Carolina's coastal plain, and developed statistical models to identify the dominant multi-scale abiotic environmental factors that influence assemblage structure. Our analyses indicated the presence of four predominant fish assemblages that commonly occur in the coastal plain, which we termed the: 1) fluvial, 2) eastern mudminnow, 3) centrarchid, and 4) non-fluvial assemblages. Natural geographic gradients and instream habitat parameters associated with velocity, channel form, stream size, and …


Development And Evaluation Of An Enrichment Culture For Reductive Dechlorination Of Tetrachloroethene Under Low Ph Conditions, Rui Xiao Aug 2014

Development And Evaluation Of An Enrichment Culture For Reductive Dechlorination Of Tetrachloroethene Under Low Ph Conditions, Rui Xiao

All Theses

Perchloroethene (PCE) is a pollutant of major environmental concern at hazardous waste sites worldwide. PCE and trichloroethene (TCE) are suspected carcinogens and are ranked 16th and 31st, respectively, on the Environmental Protection Agency's priority list for hazardous substances, developed under the Comprehensive Environmental Response, Compensation, and Liability Act. As a consequence of the widespread use of chlorinated solvents (including PCE and TCE) for dry cleaning, chemical feedstocks, metal degreasing and other purposes, chloroethenes are widely distributed in the environment. Many soils and groundwater throughout the world are contaminated by chloroethenes. Therefore, further improvements are needed in clean-up methods. Bioaugmentation has …


Evaluation Of 2,4-D And Dicamba Based Herbicide Programs For Weed Control In Tolerant Soybean, Dwayne Joseph Aug 2014

Evaluation Of 2,4-D And Dicamba Based Herbicide Programs For Weed Control In Tolerant Soybean, Dwayne Joseph

All Theses

Weeds are the most limiting factor on soybean yields in South Carolina. With their early emergence and rapid growth, weeds compete with crops for resources. The recent evolution of herbicide resistant weeds has made it increasingly difficult for growers to actively control weeds in fields. Glyphosate and ALS-resistant Palmer amaranth (Amaranthus palmeri S. Watson) biotypes have spread rapidly throughout South Carolina, especially in areas where resistance management isn't practiced. In the near future, soybean varieties will be introduced with tolerance to 2,4-D (Dow AgroSciences) and dicamba (Monsanto Company). Field and greenhouse experiments were conducted at Edisto Research and Education Center …


Cooking Healthy, Eating Smart (Ches): Evaluating The Feasibility Of Using Volunteers To Deliver Nutrition And Food Safety Education To Rural Older Adults, Morgan Getty Aug 2014

Cooking Healthy, Eating Smart (Ches): Evaluating The Feasibility Of Using Volunteers To Deliver Nutrition And Food Safety Education To Rural Older Adults, Morgan Getty

All Theses

Due to their limited resources, rural, older adults in the United States are at risk for poor diet-related health outcomes. Nutrition education is a key component in improving health outcomes in older adults. Cooking Healthy, Eating Smart (CHES) is a nine-lesson curriculum designed to teach rural, older adults culturally appropriate nutrition and food safety information. Funding to hire health professionals to deliver such a curriculum is limited, presenting the need to explore a less expensive mode of dissemination. In this community-based, participatory research study, a formative evaluation and feasibility study were conducted to examine the use of volunteers to deliver …


Repair Of The Proboscis Of Brush-Footed Butterflies (Lepidoptera: Nymphalidae), Suellen Pometto Aug 2014

Repair Of The Proboscis Of Brush-Footed Butterflies (Lepidoptera: Nymphalidae), Suellen Pometto

All Theses

A key feature of the order Lepidoptera is the coilable proboscis, present in over 99% of lepidopteran species. The proboscis is used to obtain liquid nutrition, usually floral nectar. The proboscis is assembled from two elongate galeae immediately after emergence of the adult from the pupa. What happens if the galeae become separated? I studied the process of repair of the proboscis, behaviorally and functionally, at the organismal level. My research questions were as follows: 1) is the proboscis capable of repair, 2) is saliva necessary to proboscis repair, and 3) is the repaired proboscis able to acquire fluids? Test …


Use Of Macroinvertebrates In Bioassessment Of Land Use And Water Quality In Northern Mongolia, Oyunchuluun Yadamsuren Jul 2014

Use Of Macroinvertebrates In Bioassessment Of Land Use And Water Quality In Northern Mongolia, Oyunchuluun Yadamsuren

All Dissertations

Land-use practices in Mongolia lead to habitat degradation and consequently affect the structure and function of biological communities. There is no accepted bioassessment technique for determining the ecological consequences of habitat degradation on biological communities and water quality in Mongolia, such that a monitoring and management program suitable for Mongolia is sorely needed. Both a trait-based approach and the North American Rapid Bioassessment Protocol (RBP) metrics were tested with macroinvertebrates to determine the performance and applicability of these approaches for predicting general ecological responses of freshwater and terrestrial communities to habitat variation due to overgrazing and mining in northern Mongolian …


Potential Susceptibility Of Canna Flaccida And Two Canna Hybrids To Five Species Of Phytophthora, Kristin Van Kampen Jul 2014

Potential Susceptibility Of Canna Flaccida And Two Canna Hybrids To Five Species Of Phytophthora, Kristin Van Kampen

All Theses

The costs and need for clean water are increasing for greenhouse, nursery, and agricultural businesses. Runoff from irrigated agriculture and specialty crops also can take a toll on the surrounding environment, because irrigation runoff water can contain high amounts of nutrients, contaminants, and plant pathogens. To assuage the pollution contributed to runoff water and reduce the overall volume of water used, nurseries are starting to reuse irrigation runoff water. For this to be possible, the water first should be treated before reuse. Constructed wetlands are a biological treatment option that employs vegetation to collect, filter, and store runoff water. Some …


The Genus Palaeagapetus Ulmer (Trichoptera, Hydroptilidae, Ptilocolepinae) In North America, Tomiko Ito, Robert W. Wisseman, John C. Morse, Murray H. Colbo, John S. Weaver Iii May 2014

The Genus Palaeagapetus Ulmer (Trichoptera, Hydroptilidae, Ptilocolepinae) In North America, Tomiko Ito, Robert W. Wisseman, John C. Morse, Murray H. Colbo, John S. Weaver Iii

Publications

The genus Palaeagapetus Ulmer (Trichoptera, Hydroptilidae, Ptilocolepinae) is revised in North America. Descriptions of the western species, P. nearcticus Banks 1938, are provided with the first descriptions of the female, pupa, larva, egg and case and with notes on food, habitat and annual life cycle. The male and female of the eastern species, P. celsus Ross 1936, are described or redescribed with some ecological notes. Distributions of the two species are summarized.


Avs Corner, May 2014, Kathy Still, Johanna Johnson, Allison Millican, Megan Kelley, Michelle Brauneis, Tina Rowland May 2014

Avs Corner, May 2014, Kathy Still, Johanna Johnson, Allison Millican, Megan Kelley, Michelle Brauneis, Tina Rowland

AVS Corner

No abstract provided.


The Reference Transcriptome Of The Adult Female Biting Midge (Culicoides Sonorensis) And Differential Gene Expression Profiling During Teneral, Blood, And Sucrose Feeding Conditions, Dana Nayduch, Matthew B. Lee, Christopher Saski May 2014

The Reference Transcriptome Of The Adult Female Biting Midge (Culicoides Sonorensis) And Differential Gene Expression Profiling During Teneral, Blood, And Sucrose Feeding Conditions, Dana Nayduch, Matthew B. Lee, Christopher Saski

Publications

Unlike other important vectors such as mosquitoes and sandflies, genetic and genomic tools for Culicoides biting midges are lacking, despite the fact that they vector a large number of arboviruses and other pathogens impacting humans and domestic animals world-wide. In North America, female Culicoides sonorensis midges are important vectors of bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV), orbiviruses that cause significant disease in livestock and wildlife. Libraries of tissue-specific transcripts expressed in response to feeding and oral orbivirus challenge in C. sonorensis have previously been reported, but extensive genome-wide expression profiling in the midge has not. Here, we …


Influence Of Periostin On Bone Marrow-Derived Cell Contribution To Dermal Wound Repair, Suzanne Parks May 2014

Influence Of Periostin On Bone Marrow-Derived Cell Contribution To Dermal Wound Repair, Suzanne Parks

All Dissertations

Originally thought to function only as a scaffold, the extracellular matrix (ECM) is now understood to provide signals that regulate all aspects of cellular phenotype. Matricellular proteins are a subset of ECM-related molecules defined by their ability to modulate interactions between cells and the ECM. Periostin was recently classified as a matricellular protein based on its expression and function during development and wound repair. Periostin has been shown to influence cell behavior and collagen fibrillogenesis in several tissue types. In this study, we examined how periostin expression influences fibrocyte behavior after dermal injury using periostin null (Pstn -/-) and wild-type …


The Effects Of Indirubin-3’-(2,3 Dihydroxypropyl)-Oximether (E804) On Inflammation Profile In Macrophages, Amy Lauren Anderson May 2014

The Effects Of Indirubin-3’-(2,3 Dihydroxypropyl)-Oximether (E804) On Inflammation Profile In Macrophages, Amy Lauren Anderson

All Dissertations

Indirubin is a deep-red bis-indole isomer of indigo blue, both of which are biologically active ingredients in Danggui Longhui Wan, an ancient Chinese herbal tea mixture used to treat neoplasia and chronic inflammation, and to enhance detoxification of xenobiotics. Multiple indirubin derivatives have been synthesized and shown to inhibit cyclin-dependent kinases (CDKs) and glycogen-synthase kinase (GSK-3β) with varying degrees of potency. Several indirubins are also aryl hydrocarbon receptor (AhR) agonists, with AhR-associated activities covering a wide range of potencies, depending on structure-activity-relationships (SAR). In this study, the effects on indirubin-3’-(2,3 dihydroxypropyl)-oximether (E804), a novel indirubin derivative with potent effects on …