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Full-Text Articles in Life Sciences
Insight Into The Interaction Between The Peroxisome Proliferator-Activated Receptor Gamma (Pparγ) And Adipocyte Fatty Acid-Binding Protein (A-Fabp), Qian Wang
Dissertations, Theses, and Capstone Projects
The Adipocyte Fatty Acid-Binding Protein (AFABP) is mainly expressed in fat cells. It can bind fatty acids and other lipophilic substances such as eicosanoids and retinoids. The peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor protein that requires ligand binding to regulate the specific gene transcription. PPARγ is expressed at extremely high levels in adipose tissue, macrophages, and the large intestine, where it controls lipid adipogenesis and energy conversion. Moreover, it has been found that AFABP and PPARγ can form a complex in vivo. It is proposed that AFABP carries the ligand and enters into the nucleus where it …
Characterization Of Lipid Rafts In Human Platelets Using Nuclear Magnetic Resonance: A Pilot Study, Joshua F. Ceñido, Boris Itin, Ruth E. Stark, Yung-Yu Huang, Maria A. Oquendo, J. John Mann, M. Elizabeth Sublette
Characterization Of Lipid Rafts In Human Platelets Using Nuclear Magnetic Resonance: A Pilot Study, Joshua F. Ceñido, Boris Itin, Ruth E. Stark, Yung-Yu Huang, Maria A. Oquendo, J. John Mann, M. Elizabeth Sublette
Publications and Research
Lipid microdomains (‘lipid rafts’) are plasma membrane subregions, enriched in cholesterol and glycosphingolipids, which participate dynamically in cell signaling and molecular trafficking operations. One strategy for the study of the physicochemical properties of lipid rafts in model membrane systems has been the use of nuclear magnetic resonance (NMR), but until now this spectroscopic method has not been considered a clinically relevant tool. We performed a proof-of-concept study to test the feasibility of using NMR to study lipid rafts in human tissues. Platelets were selected as a cost-effective and minimally invasive model system in which lipid rafts have previously been studied …