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Chapman University

Theses/Dissertations

2020

MSU crystals

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Full-Text Articles in Life Sciences

Cluster Determinant 44 (Cd44) Receptor And Gout: Mechanistic Role In Pathogenesis And Therapeutic Targets, Emira Bousoik May 2020

Cluster Determinant 44 (Cd44) Receptor And Gout: Mechanistic Role In Pathogenesis And Therapeutic Targets, Emira Bousoik

Pharmaceutical Sciences (PhD) Dissertations

Gout is considered one of the most common forms of arthritis. It is characterized by sudden, severe attacks of pain, redness, and swelling in the joints. Management of acute gout attacks remains suboptimal, and hospitalizations due to poorly controlled flares have significantly increased over the past two decades. Colchicine is considered one of the first-line treatments for the relief of the symptoms associated with gout attacks. However, the use of colchicine for gout therapy has limitations due to the severe adverse effects, including fatalities. Acute gout is caused by deposition of monosodium urate (MSU) crystals in peripheral joints and surrounding …