Life Sciences Commons^™

Preventing Alzheimer's: Effects Of Second Language Acquisition In Older Populations, Joshua Rhead

Undergraduate Honors Theses

Alzheimer’s disease continues to be a problem that medicine has few answers for. As a result, much research has been focused on finding a cure as well as interventions to help prevent the onset of the disease. One such intervention that has been proposed is to improve the brain’s efficiency and connectivity. A controversial method of achieving these results is through second language acquisition. Many provide evidence for or against the benefits of this intervention, but much remains unclear. Most of these studies focus on cognitive function and functional connectivity in language areas, but the default mode network, which is …

The Effects Of A Three-Hour, After School Bout Of Sedentary Vs Active Behavior On Reward And Cognitive Control Activation In 8- To 9-Year-Old Children: A Randomized Crossover Study, Mary Linn White

Theses and Dissertations

PURPOSE: To compare the effects of after-school sedentary versus active play on activation in the reward and cognitive control regions of the brain to pictures of high- and low-calorie foods. METHODS: 32 children (12 girls, 20 boys; age 8.7 ± 0.5 years; height 137.9 ± 6.9 cm; weight 32.4 ± 6.2 kg) participated in a randomized crossover study with counterbalanced treatment conditions. Conditions took place on separate days after school and included three hours of active or sedentary play. After each condition, neural activation in reward and cognitive control regions of the brain were assessed using functional magnetic resonance imaging …

Fixation-Related Fmri And Syntactic Networks In The Brain, Brent Foster, Ben Carter, Steven Luke

FHSS Mentored Research Conference

Humans comprehend language at varying levels of complexity. Syntax, in particular, deals with the arrangement of words and phrases into meaningful sentences. For instance, in English we expect most sentences to follow some variation of the order "Subject-Verb-Object: such as "The boy (Subject) ate (Verb) cake (Object)." On the surface, such grammatical rules seem simple. However, our understanding of how the brain implements these rules to understand sentences is incomplete.

Syntax appears to be associated with Broca's area in the frontal lobe and various regions of the left temporal lobe. However, recent research has provided controversial data suggesting that the …

Neural Activation In Blood-Flow-Restricted Versus Non-Blood-Flow-Restricted Exercise: An Fmri Study, Tiffany Dawn Devries

Theses and Dissertations

Functional magnetic resonance imaging (fMRI) can be used to track neural activation in the brain during functional activities. The purpose of this study was to investigate brain neural responses to blood flow restricted (BFR) versus control handgrip exercise. Using a randomized crossover design, 25 subjects (12 males, 13 females) completed handgrip exercises during two conditions: BFR vs. control. To familiarize participants with the exercise conditions, one week prior to MRI scanning participants completed each exercise condition once on separate days, with 72 hours between days. The following week fMRI scans were performed at the same time of day, separated by …

A Neuroimaging Investigation Of The Effects Of Age And Sleep On Pattern Separation, Christopher Robert Doxey

Theses and Dissertations

Effective memory representations must be specific to prevent interference between episodes that may overlap in terms of place, time, or items present. Pattern separation, a computational process performed by the hippocampus overcomes this interference by establishing non-overlapping memory representations. This project explores pattern separation and how it is impacted by age and sleep. Experiment 1. Structures of the medial temporal lobe (MTL) are known to be involved in declarative memory processes. However, little is known about how age-related changes in MTL structures, white matter integrity, and functional connectivity affect pattern separation processes in the MTL. In the present study, we …

Neural Reactivity To Visual Food Stimuli In The Morning And Evening: An Fmri Study In Women, Travis Daniel Masterson

Theses and Dissertations

Background: Visual food stimuli have been shown to influence desire to eat and may influence overall energy intake. The purpose of this study was to determine the influence, if any, that time of day has on the neural response to visual food stimuli, as measured by functional magnetic resonance imaging (fMRI). Methods: Using a crossover design, 15 healthy women were scanned using fMRI while presented with low- and high-energy pictures of food, once in the morning (6:30–8:30 am) and once in the evening (5:00–7:00 pm). Diets were identical on both days of the fMRI scans and were verified using weighed …

A Parametric Investigation Of Pattern Separation Processes In The Medial Temporal Lobe, Sarah E. Motley

Theses and Dissertations

The hippocampus is thought to be involved in memory formation and consolidation, with computational models proposing the process of pattern separation as a means for encoding overlapping memories. Previous research has used semantically related targets and lures to investigate hippocampal responses to mnemonic interference. Here, we attempted to define the response function of the hippocampus and its inputs during pattern separation by parametrically varying target-lure similarity in a continuous recognition task. We also investigated the effect of task demands (intentional versus incidental encoding) on pattern separation processes. We collected functional magnetic resonance imaging (fMRI) data while participants were shown a …