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Full-Text Articles in Life Sciences
Identifying And Understanding Factors That Affect The Translation Of Therapies From The Laboratory To Patients: A Study Protocol, Manoj M. Lalu, Joshua Montroy, C Glenn Begley, Tania M. Bubela, Victoria Hunniford, David Ripsman, Neil Wesch, Jonathan Kimmelman, Malcolm Macleod, David Moher
Identifying And Understanding Factors That Affect The Translation Of Therapies From The Laboratory To Patients: A Study Protocol, Manoj M. Lalu, Joshua Montroy, C Glenn Begley, Tania M. Bubela, Victoria Hunniford, David Ripsman, Neil Wesch, Jonathan Kimmelman, Malcolm Macleod, David Moher
Office of the Provost
Background: The process of translating preclinical findings into a clinical setting takes decades. Previous studies have suggested that only 5-10% of the most promising preclinical studies are successfully translated into viable clinical applications. The underlying determinants of this low success rate (e.g. poor experimental design, suboptimal animal models, poor reporting) have not been examined in an empirical manner. Our study aims to determine the contemporary success rate of preclinical-to-clinical translation, and subsequently determine if an association between preclinical study design and translational success/failure exists.
Methods: Established systematic review methodology will be used with regards to the literature search, article screening …
Vitamin D Status And Risk Of Incident Tuberculosis Disease: A Nested Case-Control Study, Systematic Review, And Individual-Participant Data Meta-Analysis, Omowunmi Aibana, Chuan-Chin Huang, Said Aboud, Alberto Arnedo-Pena, Mercedes C. Becerra, Juan Bautista Bellido-Blasco, Ramesh Bhosale, Roger Calderon, Rabia Hussain, Najeeha Talat Iqbal
Vitamin D Status And Risk Of Incident Tuberculosis Disease: A Nested Case-Control Study, Systematic Review, And Individual-Participant Data Meta-Analysis, Omowunmi Aibana, Chuan-Chin Huang, Said Aboud, Alberto Arnedo-Pena, Mercedes C. Becerra, Juan Bautista Bellido-Blasco, Ramesh Bhosale, Roger Calderon, Rabia Hussain, Najeeha Talat Iqbal
Department of Pathology and Laboratory Medicine
Background: Few studies have evaluated the association between preexisting vitamin D deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D levels on TB disease risk.
Methods and Findings: We assessed the association between baseline vitamin D and incident TB in a prospective cohort of 6,751 HIV-negative household contacts of TB patients enrolled between September 1, 2009, and August 29, 2012, in Lima, Peru. We screened for TB disease at 2, 6, and 12 months after enrollment. We defined cases as household contacts who developed TB disease at least 15 days after enrollment of the index patient. …