Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
The Effects Of A Nad(P)H Oxidase Inhibition On Matrix Metalloproteinases And Timp-1 In The Mdx Diaphragm, Jong-Hee Kim, Hyo-Bum Kwak, John M. Lawler
The Effects Of A Nad(P)H Oxidase Inhibition On Matrix Metalloproteinases And Timp-1 In The Mdx Diaphragm, Jong-Hee Kim, Hyo-Bum Kwak, John M. Lawler
International Journal of Exercise Science: Conference Proceedings
Duchenne muscular dystrophy (DMD) is characterized by devastating muscle degeneration that includes oxidative stress, loss of contractile tissue, muscle weakness and increased fibrosis in respiratory muscles (e.g., diaphragm). The mdx mice diaphragm undergoes a progressive degeneration similar to that occurring in patients with DMD. We showed that apocynin, a NAD(P)H oxidase inhibitor, protects against reduction in diaphragm mass, oxidative capacity, and apoptosis. We hypothesized that apocynin (1.5mmol/L per day) would attenuate extramyocyte space and collagen content by ameliorating matrix metalloproteinases (e.g., MMP-2, MMP-9), tissue inhibitors of metalloproteinases (e.g., TIMP-1) and transforming growth factor-β (TGF-β) in the mdx diaphragm. Eight to …