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Exercise Attenuates Ctgf Levels, Delaying The Onset Of Fibrosis In The Aging Left Ventricle, Claire N. Canon, Jong-Hee Kim, Sean M. Courtney, Brandon Macias, John M. Lawler
Exercise Attenuates Ctgf Levels, Delaying The Onset Of Fibrosis In The Aging Left Ventricle, Claire N. Canon, Jong-Hee Kim, Sean M. Courtney, Brandon Macias, John M. Lawler
International Journal of Exercise Science: Conference Proceedings
Aging is associated with a progressive increase in collagen (i.e., fibrosis) in the aging heart. Fibrosis is associated with a stiffening of the heart and a decrease in heart function. Previous data (Kwak, 2008) showed that matrix metalloproteinase (MMP) activity in the aging heart is decreased linked to an elevation TIMP-1 (tissue inhibitor of MMPs-1); while exercise training increased TIMP-1 and reduced MMP expression. Connective tissue growth factor (CTGF) is an upstream inhibitor of TIMP-1 and is implicated in diabetes and heart failure. We hypothesized that exercise would decrease CTGF levels, thus reducing fibrosis in the aged left ventricle. Young …