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Identification And Characterization Of The Glucagon-Like Peptide-2 Hormonal System In Ruminants, Christina C. Taylor Edwards
Identification And Characterization Of The Glucagon-Like Peptide-2 Hormonal System In Ruminants, Christina C. Taylor Edwards
University of Kentucky Doctoral Dissertations
The hormone glucagon-like peptide-2 (GLP-2) is important in the regulation of intestinal growth and blood flow in nonruminant animals. However, no research reports the existence of GLP-2 in ruminants. Therefore, this dissertation examined the existence of GLP-2 and its receptor, their response to physiological stimuli, and its ability to induce gastrointestinal growth and intestinal blood flow in ruminants.
Experiments 1 and 2 established the gastrointestinal distribution of mRNA for proglucagon (the GLP-2 precursor) and the GLP-2 receptor. Furthermore, these experiments determined the effects of changing dietary energy intake on plasma GLP-2 concentrations and proglucagon and GLP-2 receptor mRNA expression. Experiment …