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The Increase In Renal Sodium Excretion In Response To Angiotensin Ii Infusion In Exercised Female Rats Is Dependent On A Rise In Renal Perfusion Pressure, Karmon Janssen
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Prior studies in this lab have shown that chronically exercised female spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats excrete a greater amount of sodium in response to angiotensin II (Ang II) infusion than do sedentary rats. The current study determined if the difference in renal sodium excretion persisted when the renal perfusion pressure (RPP) was held constant. Female SHR and female WKY rats were separated into sedentary and exercised groups at 4 weeks of age. The exercise group voluntarily exercised for at least eight weeks using an exercise wheel and time/distance monitor. At 13 weeks of age or older, …