Life Sciences Commons^™

Development Of An Enhanced Sampling Workflow To Accelerate Molecular Docking With Sparse Biophysical Information, Zachary Stichter

Masters Theses & Specialist Projects

Rapid docking of flexible biological macromolecules remains a significant open challenge in protein structure determination. While rigid docking is relatively simple with toolkits such as TagDock, a key obstacle to rapid flexible docking is the complexity and roughness of the free energy surface associated with protein conformational motion (often termed the many-minima problem), meaning conventional molecular dynamics methods do not effectively sample protein conformations near the interaction complex in accessible timescales. Methods such as metadynamics and replica exchange molecular dynamics exist to ameliorate this obstacle, yet these methods use nonphysical biases or random swaps to enhance sampling. In contrast, high …

The Effect Of Mindfulness Training On Muscular Endurance Exercise Performance, Mindfulness, And Mental Toughness, Donte Mcgee

Masters Theses & Specialist Projects

INTRODUCTION: Mindfulness training is a method of mental training becoming increasingly popular and has been positively associated with mental toughness, which may be valuable in highly fatiguing and stressful activities, like endurance exercise. Mindfulness training has resulted in increased endurance performance, but limited literature exists on a similar modality, muscular endurance exercise. The purpose of this study is to examine the effect of an acute bout of mindfulness meditation on muscular endurance performance, mindfulness, and mental toughness. METHODS: Participants (n=24) completed two sessions, a week apart, of three planks until fatigue, with one-minute rest intervals. Immediately following each plank, RPE …

Synthesis Of Gold Nanoparticles Via Pulsed Liquid Ablation For Use In The Photodynamic Therapy Of Bacteria, Justice Ben Yosef

Masters Theses & Specialist Projects

With the ever-increasing threat of antibiotic resistant bacteria, alternative treatment methods have been developed including photodynamic therapy (PDT). Within the PDT process, photosensitizers are used to generate reactive oxygen species (ROS) and facilitate the cell termination process. This work lays the conceptual foundation for the functionalization of the photosensitizer methylene blue (MB) with gold nanoparticles (AuNPs) and INF-55 as a potential inhibitor of the AcrAB-TolC efflux pump to enhance the effectivity of the PDT process.

AuNPs were synthesized using pulsed laser ablation in an aqueous citrate solution. Both nanosecond and picosecond pulse durations, as well as both 532 nm and …

Acl Bracing: Is It Still Being Done Clinically And Does It Influence Confidence And/Or Biomechanical Performance During A Drop Vertical Jump?, Bailey Watson

Masters Theses & Specialist Projects

Introduction: Anterior cruciate ligament (ACL) ruptures account for 60% of sports-related injuries and the gold standard for treatment is surgical intervention to replace the damaged ligament to restore function of the ACL. Braces are typically used to return to previous physical activity levels; however, there are no clear guidelines on their utilization. Beyond the physical consequences of undergoing ACL reconstruction surgery, the psychological component is often ignored.

Purpose: The aim of this study is to better understand the impact of knee bracing on both biomechanical factors and confidence following ACL reconstruction. Two aims comprise the overarching purpose; the first is …

Cannabidiol (Cbd) And Resistance Training: Does Cbd Attenuate Acute Pain?, Guillermo Pacheco

Masters Theses & Specialist Projects

INTRODUCTION: Resistance training (RT) is an advantageous form of physical activity for health and performance benefits; these benefits are maximized when done strenuously. However, strenuous RT can induce acute inflammatory pain which can lead to delayed-onset muscle soreness (DOMS). Common analgesics like non-steroidal anti-inflammatory drugs (NSAIDs) can block protein synthesis, so other alternatives are needed for exercise and athletic communities to maintain physiological adaptations. Cannabidiol (CBD) is a non-psychotropic cannabinoid with purported anti-inflammatory, anti-oxidative, and analgesic properties. One of the main reasons for the use of CBD in exercise is pain alleviation; however, research in humans is limited. Therefore, the …

Grey Relational Analysis And Canonical Correlation Analysis Of Air Pollution In Three Kentucky Counties, Sarah Hartman

Masters Theses & Specialist Projects

Air pollution is a crucial factor that affects both the environment and public health. Various methods are available for assessing air quality and pollution levels, such as regression models, principal component analysis, and factor analysis tools. However, some of these methods present issues in multicollinearity and the nature of collected data. It is important to recognize that air pollution data is often uncertain, incomplete, and contains limited valid data points. Weather conditions and economic activities are also factors that can affect air pollution. With growing communities in Kentucky (KY), it is essential to address these factors as the state has …

The Effects Of A Guided Mindful Walk On Mental Health In University Students, Ashley V. Burdick, Sarah M. Camhi

International Journal of Exercise Science

International Journal of Exercise Science 17(5): 590-601, 2024. College campuses in the United States are experiencing high levels of mental distress without adequate psychological resources to address the need. In addition, the majority of university students do not meet the physical activity guidelines for mental and physical health. Effective and time efficient resources are needed to address poor mental health and low physical activity among university students on college campuses. Mindful walking may be a promising solution. The purpose was to 1) measure change in mental health and 2) estimate physical activity from participation in a guided mindful walk in …

Comparison Of Self-Reported Physical Activity And Wearable Device-Xiaomi Mi2 Band In Preadolescent School Children-A Pilot Crossesctional Study, Aysha Almas, Shiraz Hashmi, Adil Elahi, Om Parkash, Sania Sabir, Romaina Iqbal

International Journal of Exercise Science

International Journal of Exercise Science 17(7): 565-575, 2024. The purpose of this study is to compare physical activity measured by the wearable device Xiaomi Mi2 Band and self-reported physical activity by YPAQ in preadolescent school children. A pilot cross-sectional study was performed on a subsample (5%=n=60) of preadolescent children within a parallel-group feasibility intervention trial (n=1000). All children aged 9-11 years enrolled in the schools were included in the study and children with any physical disability were excluded. Self-reported physical activity was recorded through the modified version of the Youth Physical Activity Questionnaire (YPAQ) and automatic physical activity was measured …

Effects Of Resistance Training Techniques On Metabolic Responses In Trained Males, Alysson Enes, Ragami Chaves Alves, Vinicius Zen, Danilo Fonseca Leonel, Gustavo Oneda, Luis H. B. Ferreira, Luciano R. Guiraldelli, Roberto Simão, Guillermo Escalante, Anderson Z. Ulbrich, Tácito P. Souza-Junior

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 576-589, 2024. This study investigated the effects of bi-set, drop-set and traditional resistance training (RT) techniques on metabolic responses in resistance-trained males. Fifteen trained males (age 29.7 ± 6.1 years; body mass 83.4 ± 7.6 kg; RT experience 11.4 ± 6.7 years; one-repetition maximum (1RM) barbell bench press: body mass ratio 1.4 ± 0.1 a.u.) were assigned to three experimental conditions, in a randomized crossover design. The experimental conditions were bi-set (3x10 repetitions at 70%1RM in barbell bench press followed by 10 repetitions at 60%1RM in incline bench press), drop-set (3x10 repetitions at …

The Effects Of Virtual Group Study On Class Views And Performance, W. Matt Denning, Robert S. Thiebaud, Lindy M. Rossow

Educational Practices in Kinesiology

Peer-to-peer teaching improves academic performance. During the worldwide pandemic, peer-to-peer teaching was unavailable, and feelings of isolation and loneliness increased. This study investigated the impact of virtual peer-to-peer group study on student performance and class views in a virtual, undergraduate exercise physiology course. Sixty-nine college-aged adults were randomly assigned to study with a virtual group or individually for two instructional units. Students switched groups after the first unit. For virtual group study, students met virtually for at least one hour outside of class to study course content. Those assigned to the individual study did not study virtually with classmates. Unit …

The Effectiveness And Perceptions Of Three Moderate Intensity Walking Cadence Aids And Their Effects On Affective States: A Mixed Methods Study, Daniel Brown, Phillip Gray, Julie Doherty, Ellen Ea Simpson

International Journal of Exercise Science

International Journal of Exercise Science 17(5): 531-550, 2024. Substantial health benefits can be derived from walking at a moderate intensity cadence. To help regulate this cadence, three distinct aids exist 1) self-perception; 2) cadence prescription; 3) auditory cues. This study aimed to compare the effectiveness and explore perceptions of these aids to promote moderate intensity walking and effects on affective states, thereby addressing an important research gap. Individualised moderate relative intensity waking cadence was determined for participants (n = 23, M_age = 26.35, SD = 10.11). A convergent mixed-methods design was employed. A within-persons repeated measures design was used …

The Immediate Effects Of Dry Cupping The Lumbar Paraspinals On Range Of Motion And Temperature, Natasha Scavarelli, Paolo Sanzo

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 551-564, 2024. Dry cupping is a therapeutic modality proposed to produce a negative pressure, stretching the skin and underlying tissue. This mechanism is said to promote regional blood flow of oxygenated blood and causing a physiological stretch in the tissue, allowing it to elongate and potentially changing skin temperature. The possible effects of the application to the lumbar spine paraspinal muscles, however, has not been thoroughly examined. The purpose of this pilot study was to explore the immediate effects of dry cupping the lumbar paraspinals on lumbar spine range of motion (ROM) and overlying …

Nutrient Intake, Performance, And Body Composition Of Preseason Wrestlers, Gregory-James Coapstick, Allison Barry, Crystal Levesque, Marni Shoemaker

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 517-530, 2024. College athletes, especially in weight class sports, often experience energy deficits. Athletes competing in weight class sports such as wrestling are at greatest risk for deficiencies and little is known about the relationships between body composition, nutrient intake, and performance in these athletes. The purposes of this study were to (1) quantify macronutrient and micronutrient intake of pre-season male collegiate wrestlers and compare to estimated needs, and (2) examine relationships among nutritional intakes, body composition, and performance measurements of strength and anaerobic capacity. Male Division I wrestlers (n = 11, age: …

Influence Of Ambient Temperature On Autonomic Nerve Function And Peripheral Sensation From Moderate-Intensity Treadmill Exercise, Sunao Wada, Mh Mahbub, Natsu Yamaguchi, Ryosuke Hase, Tsuyoshi Tanabe

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 491-503, 2024. Objective: The main objective was to ascertain the acute responses in autonomic nervous activity and peripheral sensation induced by moderate-intensity treadmill exercise performed under different ambient temperatures. Methods: Twelve young healthy subjects underwent three sessions of moderate-intensity treadmill exercise (warming, 5 min and running, 25 min), on different days under 10°C, 20°C and 30°C room temperatures. Pre- and post-intervention, heart rate variability (HRV) and plantar vibrotactile perception threshold (VPT) were measured. Additionally, rate of perceived exertion (RPE) was recorded after intervention. Results: In comparison with the corresponding baseline values, after intervention, low …

Progressive Arm Cycling Ergometry With 3- And 5-Minute Stage Durations Yields Similar Estimates Of Substrate Oxidation In Healthy Adults, Todd A. Astorino Ph.D, Zachary Jordan, Cristian Gonzales, Carly Schuerger, Muhammed M. Atakan

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 468-479, 2024. Arm cycling ergometry (ACE) leads to a lower maximal oxygen uptake (VO₂max) than cycling which is related to a smaller active muscle mass. This study compared estimates of fat and carbohydrate oxidation (FOx and CHOOx) between progressive exercise protocols varying in stage duration in an attempt to create a standard exercise protocol for determining substrate metabolism using ACE. Four men and seven women (age = 24 ± 9 yr) unfamiliar with ACE completed incremental exercise to determine peak power output and VO₂peak. During two subsequent sessions completed after …

Influence Of Physical Activity Including Squat Exposure On Trunk Muscle Strength And Labour Outcome In Pregnant Women, Rajal Savla, Rajani Mullerpatan, Bela Agarwal, Victoria Kuttan, Sushil Kumar

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 504-516, 2024. Daily living physical activities of rural pregnant women, across most continents in the world, involve adoption of high-flexion postures like deep-squat. Deep-squat elicits substantial activation of major trunk and lower extremity muscles. Adequate strength of trunk muscles is known to facilitate forward-downward propulsion of baby during labour. Therefore, current study aimed to explore influence of overall physical activity including squat exposure on trunk and lower-extremity muscle strength and labour outcomes in rural and urban primigravida women. Twenty-eight primi-gravida women were stratified into 2 groups: rural habitual-squatters (n=14) and urban non-squatters (n=14). Daily …

The Quantification Of Muscle Activation During The Loaded Carry Movement Pattern, Samuel H. Ellestad, Thomas P. Holcomb, Alexis M. Swiergol, Michael E. Holmstrup Phd, Jeremy R. Dicus

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 480-490, 2024. The ‘loaded carry’ is a popular resistance training activity that activates core musculature across multiple movement planes while the body is in locomotion. ‘Hold’ exercises are similar to carry exercises but lack the locomotive aspect. Both carry and hold exercises can be completed bilaterally (farmer’s carry (FC) and hold (FH)) or unilaterally (suitcase carry (SC) and hold (SH)). A deeper understanding of muscle activation between the FC and SC and intensity-matched FH and SH might improve their application. Healthy, college-aged individuals were recruited and surface electromyography of the rectus abdominis (RA), external …

The Effects Of Lower Leg Compression Garments On Lower Extremity Sports Injuries, Subjective Fatigue And Biomechanical Variables: A Systematic Review With Meta-Analysis, Thierry P.C. Franke, Hetty Hofstede, Anke Van Den Broek, Bionka M.A. Huisstede Dr.

International Journal of Exercise Science

International Journal of Exercise Science 17(6): 445-467, 2024. The objective of this study was to systematically review the literature on the effect of CGs versus non-CGs (such as regular socks) or versus placebo garments on 1) the incidence of lower extremity sports injuries and 2) subjective ratings of fatigue and biomechanical variables in athletes at participating in any sport that required any level of running performance, given that fatigue-related biomechanical alterations may increase the risk of sports injuries. This study was a systematic review with meta-analyses. PubMed, Embase, CINAHL, Cochrane, PEDro, and Scopus were searched for eligible studies until 7 …

Alfred Russel Wallace Notes 30. Wallace A Theist? Part I., Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace (1823−1913) has been portrayed as a ‘theist’ on a large number of occasions from his own time on to the present. In this, the first of a two part work, this assessment is questioned. In part one, the matter of Wallace’s personal philosophy and spiritual orientation is explored, the conclusion being that Wallace was a lifelong agnostic who can hardly be aligned with theism.

Implementing Meta-Session Autoregulation Strategies For Exercise- A Scoping Review, Adam Ibrahim, Cory T. Beaumont, Kelley Strohacker

International Journal of Exercise Science

International Journal of Exercise Science 17(5): 382-404, 2024. Meta-session autoregulation, a person-adaptive form of exercise prescription that adjusts training variables according to daily fluctuations in performance considering an individual’s daily fitness, fatigue, and readiness-to-exercise is commonly used in sports-related training and may be beneficial for non-athlete populations to promote exercise adherence. To guide refinement of meta-session autoregulation, it is crucial to examine the existing literature and synthesize how these procedures have been practically implemented. Following PRIMSA guidelines a scoping review of two databases was conducted from August 2021 to September 2021 to identify and summarize the selected measures of readiness-to-exercise …

Maximal Aerobic Capacity As A Predictor Of Performance On Acft Total Score Of Rotc Cadets, Anthony M. Acevedo, Zachary Zeigler, Bridget F. Melton

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 429-437, 2024. The Army Combat Fitness Test (ACFT) is a newly developed test that assesses the combat readiness of U.S. Army soldiers. The purpose of this cross-sectional study is to determine if VO_2max can predict performance outcomes of the ACFT in ROTC cadets. This understanding can provide a better understanding of the aerobic demands of the ACFT. Cadets (50 males, 14 females; aged 21.43 ± 4.10 years) completed the 6-event ACFT (maximum trap-bar deadlift [MDL], standing power throw [SPT], hand-release pushups [HRPU], sprint-drag-carry shuttle run [SDC], plank [PLK], and 2-mile run [2MR]). The …

Influence Of Body Composition On Functional Movement Among Police Officers, Stacy L. Gnacinski, Frankie Porter, Madison N. Renner, Tessa Laska

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 418-428, 2024. Research indicates that the Functional Movement Screen (FMS) can be used to measure functional movement quality and characterize musculoskeletal injury risk in tactical populations. Although body composition has been linked to chronic disease in police officers, the link between body composition and functional movement quality has not been explored in this population. As such, the purposes of the study were to examine: (a) the effect of body mass index (BMI) on functional movement, and (b) determine the significance of fat mass (FM) and fat free mass (FFM) in predicting functional movement among …

Maximal Running Speed And Critical Speed Are Positively Related To Phase Angle In Healthy Young Adults, Trevor Short, Paulette Yamada

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 405-417, 2024. Phase Angle (PhA), derived from bioelectrical impedance analysis, is a measurement of cellular resistance to electrical current and a non-invasive tool to monitor neuromuscular performance. The relationship between PhA and components of athletic performance is not fully understood. The purpose of this study was to determine if maximal running speed, critical speed (CS), and/or D prime (D’) derived from a 3-minute all-out-test (3MAOT) correlates to PhA, reactance (Xc), or resistance (R). Sixty-one (male n=35, female n=26) healthy young adults (23.4±3.9 years) completed bioelectrical impedance analysis (Inbody770) and a 3MAOT. The correlations between …

The Effect Of Stroboscopic Vision Training On Blind-Folded Straight-Line Walking, Saira Talwar, Johneric W. Smith, John Lamberth

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 438-444, 2024. Stroboscopic vision training has shown to improve visual-motor controland dynamic visual acuity in sport performance;however, no studies have considered using this training to enhance kinesthetic awareness during walking, applicable to high fall-risk populations. Purpose: The purpose of this study was to assess the effect of stroboscopic vision training on blind-folded straight-line walking. Methods: Thirty-seven college-aged healthy participants (age: 20.14 ± 1.23 years; females: N = 32, males: N = 5) completed this study. In this pre-posttest quasi-experimental investigation, participants with no epileptic or balance disorder history completed a four-week progressive stroboscopic vision …

A Meta-Analysis Of Randomized Controlled Trials On The Effects Of Photobiomodulation Therapy On Running Performance, Ana Paula Do Nascimento, Adriano Valmozino Da Silva, Juliano Casonatto, Andreo Fernando Aguiar

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 327-342, 2024. Objective: To conduct a meta-analysis to investigate the effects of Photobiomodulation (PBM) therapy on running performance. Introduction: PBM has recently been advocated as a valuable non-pharmacological ergogenic strategy, however, the efficacy of PBM on running performance remains unproven. Methods: A computerized literature search was conducted until June 2023. The databases searched were PubMed/Medline, Embase, Scopus, SPORTDiscus, and Web of Science. Inclusion/exclusion criteria were determined through the PICO process. The running variables analyzed were time-trial or time-to-exhaustion. Results were combined with the standardized mean differences (SMD) and the 95% confidence intervals. Results: Twelve …

Effects Of Different Physical Therapy Interventions In Improving Flexibility In University Students With Hamstring Tightness- A Systematic Review And Network Meta-Analysis, Esther Liyanage, Kt Malwanage, Mkid Senarath, Hm Wijayasinghe, Indrajith Liyanage, Fmd Chellapillai, Shiromi Nishshanka

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 359-381 2024. The aim of the present study was to identify the different interventions for hamstring flexibility among university students with hamstring tightness and to determine the better treatment method. Design: Systematic review and network meta-analysis. An electronic search of the databases: Medline, Pubmed, Cochrane, EMBASE, CINAHL, Physiotherapy Evidence Database (PEDro) was conducted. A total of 11 articles were included in the review. Of these articles, 02 were case-control studies, 02 were interventional pre-post studies and 07 were RCTs. The 07 RCTs were included for network meta-analysis. The findings of the initial network meta-analysis …

Acute Effects Of A Hop-Stabilization Warm-Up Program On Dynamic Balance, Ground Reaction Force, And Muscle Activity During Cutting Movements In Collegiate Athletes With Chronic Ankle Instability, Teerapat Laddawong, Hiromi Saito, Toshiaki Soga, Hirose Norikazu

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 343-358, 2024. First-time lateral ankle sprains often lead to chronic ankle instability (CAI), with 47% facing recurrent injuries, emphasizing the need for preventive measures. Side-cutting movements in sports pose a risk for CAI individuals due to potential biomechanical control alterations. While the hop-stabilization warm-up program has proven effective in preventing ankle sprains, its specific acute impact on CAI individuals lacks substantial evidence. This study employed a crossover design with eight CAI participants (23 ± 3.4 years, BMI 23 ± 1.5 kg/m²) and eight healthy participants (25 ± 3.6 years, BMI 23 ± …

Maximal Resistance Training In The Treatment Of Anorexia Nervosa – A Case Report Series, Darren R. Healy, Nicole Mansson, Mia Furu, Solfrid Bratland-Sanda, Jan Magnus Sjögren

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 308-326, 2024. Objective: Anorexia Nervosa (AN) has one of the highest mortality rates of all mental health disorders, low recovery rate and is associated with widespread endocrine dysfunction. Resistance training (RT) has been consistently shown to provide beneficial effects on health outcomes that are often negatively affected by AN, however participation in exercise is controversial for individuals with AN. The objective of this study was to assess the effects of maximal RT as an add-on to standard of care in patients with AN. Methods: Originally, a controlled clinical trial was planned but due to …

Strengthening First Responders’ Coaching Proficiency Through A Peer Fitness Leader Workshop: A Preliminary Efficacy Trial, Sarah N. Lanham, Thomas R. Nagel, Haresh Rochani, Bridget F. Melton, Richard E. Cleveland

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 298-307, 2024. First responders require physical fitness to perform dangerous tasks in unpredictable environments. To promote physical fitness among first responders, many agencies use a peer fitness leader (PFL) approach; however, resources for the fitness, wellness, and health of PFLs are often minimal. This study’s purpose was to investigate the effectiveness of a training workshop to increase PFL’s training knowledge and coaching comfort (CC). Thirty-six PFLs (Experience: 14.6 ± 9.1 yrs; Age: 41.0 ± 9.8 yrs; BMI: 28.9 ± 7.0 kg·m^-2) attended a one-day workshop. Paired samples t-tests assessed for differences …

Using A Walking Test To Assess Firefighter Fitness, Stephanie Donahue, Bilal Chaudhry, Carly Mcmorrow, Morgan Daly, Summer B. Cook, Michael Brian, Deborah L. Feairheller

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 285-297, 2024. Tactical populations face increased risk on the job, and it is known that firefighters have high levels of cardiac-related death. Aerobic fitness is a modifiable cardiac risk factor, but many fire stations lack the proper equipment to easily assess aerobic fitness levels of their firefighters. Additionally, many fire stations lack wellness programs to hold firefighters accountable for maintaining their fitness levels. Purpose: We assessed the validity of the submaximal 6-minute walk test (6MWT) as a measure of aerobic capacity compared to a maximal treadmill test and the submaximal Gerkin protocol. Methods: Twenty-four …