Life Sciences Commons^™

Dynamic Modeling And Stochastic Simulation Of Metabolic Networks, Emalie Clement

UNO Student Research and Creative Activity Fair

Throughout our current generation, scientific studies, with the help of increased technological methods, have enabled the investigation of biology at nanoscale levels. Nevertheless, such systems necessitate the use of computational methods to comprehend the complex interactions occurring. Traditionally, dynamics of metabolic systems are described by ordinary differential equations producing a deterministic result which negates the intrinsic heterogeneity of intracellular systems. More recently, stochastic modeling approaches have gained popularity with the capability of providing more realistic outcomes. Yet, solving stochastic algorithms tend to be computationally intensive processes. Employing the queueing theory, an approach commonly used to evaluate telecommunication networks, reduces the …

Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein, Eunice Wintona

UNO Student Research and Creative Activity Fair

Smoothened receptor (SMO) is a protein that in humans, is encoded by the SMO gene. A systemic mutation in its binding pocket helps predict the sensitivity of mutant proteins to different drugs. Known as a GPCR-like receptor, it is a component of the hedgehog signaling pathway; a pathway involved in body patterning and the regulation of adult stem cells. An uncontrolled or inappropriate activation of the Hedgehog pathway drives tumor progression in cancers and a number of birth defects. To achieve these goals, the molecular modeling software MOE was used to build small molecules and drug molecules like Vismodegib and …

Towards A Mechanism Of Action Of An Antischistosomal Drug: Measuring Granulocytic Activity, Samantha Sack

UNO Student Research and Creative Activity Fair

Schistosomiasis is a neglected tropical disease caused by a family of schistosome parasites which leads to vital organ damage. Praziquantel (PZ) is the only available treatment, but it is effective only against the adult worm. Partner labs have tested an antischistosomal drug which has been shown to have a higher efficacy against both juvenile and mature parasites in mice and monkeys compared to PZ. This effectiveness does not transfer to in vitro experiments; it kills the parasite outside of its host only at extremely high concentrations. This indicates that its efficacy is host-dependent, but the mechanism by which it functions …

The Relationship Between Linear And Nonlinear Analysis On Activity Data, Katlyn J. Nimtz

UNO Student Research and Creative Activity Fair

Activity monitoring in older adults is a great way to predict disability without interfering in their daily life. We can analyze that data using linear and nonlinear analysis. While linear analysis measures the variation of activity during a specific period of time (i.e., mean, standard deviation), nonlinear analysis focuses on the evolution of activity over a period of time. Therefore, the purpose of this study was to observe the relationship between linear and nonlinear analysis of activity data obtained by activity monitoring in older adults. Eight participants wore an activity monitor around their waist for seven days. Linear analysis was …

Effect Of The Usage Of Handrails On Gait Dynamics In People With Parkinson's Disease, Daniel Jaravata, Danish Bhatti, Vivien Marmelat

UNO Student Research and Creative Activity Fair

The purpose of this project is to determine if increasing body stability during handrails-use walking on a treadmill will increase the complexity of gait variability in patients with Parkinsons disease (PD). In young healthy participants, stride time-series of walking presents a pattern of complex variability, but this complexity critically decreases in patients with PD. Complexity is defined as an optimal state between too much regularity and too much irregularity, allowing the locomotor system to maintain robust performances while being able to adapt to perturbations. A possible explanation is that the decrease in complexity results from increased control mechanisms to avoid …

Examining The Minute To Minute Predictability Of Walking Distance Across Multiple Terrains, Tyler Hamer

UNO Student Research and Creative Activity Fair

EXAMINING THE MINUTE TO MINUTE PREDICTABILITY OF WALKING DISTANCE ACROSS MULTIPLE TERRAINS

Tyler Hamer, Abderrahman Ouattas, Katlyn Nimtz, & Brian A. Knarr

Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE 68182

With findings that the 6MWT is more efficient than the original 12-minute walk test (12MWT), perhaps it can be evident that even the 6MWT can be shortened to examine its effects in a shorter duration that can be more beneficial to the participant. The objective of this study is to examine the outcomes of each minute throughout the 6MWT trials and to see if functional measures can …

Contextual Fear Learning And Memory In Alternative Stress Coping Styles, Matthew R. Baker, Ryan Y. Wong

UNO Student Research and Creative Activity Fair

Animals frequently must overcome stressors, and the ability to encode and recall these salient experiences is essential to an individual’s survival. Across many taxa, studies have documented two alternative stress coping styles (proactive and reactive) that differ in behavior, cognition, stress physiology, and underlying neuromolecular mechanisms. The role of stress in cognitive traits (e.g. learning and memory) has been well documented, however, the influence of an animal’s stress coping style on learning and memory capabilities is only beginning to be understood. Here, we developed a contextual fear learning paradigm to characterize learning and memory differences between proactive and reactive stress …