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Full-Text Articles in Life Sciences
Polyelectrolyte Complex Materials Consisting Of Antibacterial And Cell-Supporting Layers, Khairul Mat Amin, Kerry Gilmore, Jake Matic, Stephen Poon, Mark Walker, Mark Wilson, Marc In Het Panhuis
Polyelectrolyte Complex Materials Consisting Of Antibacterial And Cell-Supporting Layers, Khairul Mat Amin, Kerry Gilmore, Jake Matic, Stephen Poon, Mark Walker, Mark Wilson, Marc In Het Panhuis
Mark R Wilson
The characterization of a polyelectrolyte complex material comprised of two biopolymers, a chitosan upper layer and a gellan gum under layer, is reported. It is shown that the upper layer of chitosan with incorporated levofloxacin displays an antibacterial activity, while the under layer of a gellan gum/TiO2 composite supports the growth of fibroblastic cells.
Sex-Specific Sod Levels And Dna Damage In Painted Dragon Lizards (Ctenophorus Pictus), Mats Olsson, Mo Healey, Cecile Perrin, Mark Wilson, Michael Tobler
Sex-Specific Sod Levels And Dna Damage In Painted Dragon Lizards (Ctenophorus Pictus), Mats Olsson, Mo Healey, Cecile Perrin, Mark Wilson, Michael Tobler
Mark R Wilson
When groups of individuals differ in activities that may influence the production of reactive molecules, such as superoxide, we expect selection to result in congruent upregulation of antioxidant production in the group(s) most at risk of suffering concomitant erosion of essential tissue and biomolecules, such as DNA. We investigate this in a (near) annual lizard species, the Australian painted dragon (Ctenophorus pictus), in which males and females have fundamentally different lifestyles, with males being overtly conspicuous and aggressive, whereas females are placid and camouflaged. When kept in identical conditions to females in captivity, males had higher levels of superoxide dismutase …
Predictors Of Telomere Content In Dragon Lizards, Cissy Ballen, Mo Healey, Mark Wilson, Michael Tobler, Mats Olsson
Predictors Of Telomere Content In Dragon Lizards, Cissy Ballen, Mo Healey, Mark Wilson, Michael Tobler, Mats Olsson
Mark R Wilson
Telomeres shorten as a consequence of DNA replication, in particular in cells with low production of telomerase and perhaps in response to physiological stress from exposure to reactive oxygen species, such as superoxide. This process of telomere attrition is countered by innate antioxidation, such as via the production of superoxide dismutase. We studied the inheritance of telomere length in the Australian painted dragon lizard (Ctenophorus pictus) and the extent to which telomere length covaries with masscorrected maternal reproductive investment, which reflects the level of circulating yolk precursor and antioxidant, vitellogenin. Our predictors of offspring telomere length explained 72 % of …
A Significant Component Of Ageing (Dna Damage) Is Reflected In Fading Breeding Colors: An Experimental Test Using Innate Antioxidant Mimetics In Painted Dragon Lizards, Mats Olsson, Michael Tobler, Mo Healey, Cecile Perrin, Mark Wilson
A Significant Component Of Ageing (Dna Damage) Is Reflected In Fading Breeding Colors: An Experimental Test Using Innate Antioxidant Mimetics In Painted Dragon Lizards, Mats Olsson, Michael Tobler, Mo Healey, Cecile Perrin, Mark Wilson
Mark R Wilson
A decade ahead of their time, von Schantz et al. united sexual selection and free radical biology by identifying causal links between deep-rooted physiological processes that dictate resistance to toxic waste from oxidative metabolism (reactive oxygen species, ROS), and phenotypic traits, such as ornaments.Ten years later, these ideas have still only been tested with indirect estimates of free radical levels (oxidative stress) subsequent to the action of innate and dietary antioxidants. Here, we measure net superoxide (a selection pressure for antioxidant production) and experimentally manipulate superoxide antioxidation using a synthetic mimetic of superoxide dismutase (SOD), Eukarion 134 (EUK). We then …
Net Superoxide Levels: Steeper Increase With Activity In Cooler Female And Hotter Male Lizards, Cissy Ballen, Mo Healey, Mark Wilson, Michael Tobler, Erik Wapstra, Mats Olsson
Net Superoxide Levels: Steeper Increase With Activity In Cooler Female And Hotter Male Lizards, Cissy Ballen, Mo Healey, Mark Wilson, Michael Tobler, Erik Wapstra, Mats Olsson
Mark R Wilson
"Ectotherms increase their body temperature in response to ambient heat, thereby elevating their metabolic rate. An often inferred consequence of this is an overall upregulation of gene expression and energetic expenditure, and a concomitant increased production of reactive oxygen species (e. g. superoxide) and, perhaps, a shortened lifespan. However, recent work shows that this may be a superficial interpretation. For example, sometimes a reduced temperature may in fact trigger up-regulation of gene expression. We studied temperature and associated activity effects in male and female Australian painted dragon lizards (Ctenophorus pictus) by allowing the lizards to bask for 4 h versus …
Polymorphic Ros Scavenging Revealed By Cccp In A Lizard, Mats Olsson, Mark Wilson, Caroline Isaksson, Tobias Uller
Polymorphic Ros Scavenging Revealed By Cccp In A Lizard, Mats Olsson, Mark Wilson, Caroline Isaksson, Tobias Uller
Mark R Wilson
Ingestion of antioxidants has been argued to scavenge circulating reactive molecules (e.g., free radicals), play a part in mate choice (by mediating access to this important resource), and perhaps increase life span. However, recent work has come to question these relationships. We have shown elsewhere in the polychromatic lizard, Ctenophorus pictus, that diet supplementation of carotenoids as antioxidants does not depress circulating natural reactive oxygen species (ROS) levels and leads to no corresponding improvement of color traits. However, a much stronger test would be to experimentally manipulate the ROS levels themselves and assess carotenoid-induced ROS depression. Here, we achieve this …
Variation In Levels Of Reactive Oxygen Species Is Explained By Maternal Identity, Sex And Body-Size-Corrected Clutch Size In A Lizard, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott
Variation In Levels Of Reactive Oxygen Species Is Explained By Maternal Identity, Sex And Body-Size-Corrected Clutch Size In A Lizard, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott
Mark R Wilson
No abstract provided.
Effect Of Statins On Serum Apolipoprotein J And Paraoxonase-1 Levels In Patients With Ischemic Heart Disease Undergoing Coronary Angiography, Mark Wilson, Dimitri Mikhailidis, Maria Poulakou, Despina Perrea, Kosmas Paraskevas, Dimitrios Iliopoulos, Serafim Tsitsilonis, Ioannis Vlachos, Sonia-Athena Karabina
Effect Of Statins On Serum Apolipoprotein J And Paraoxonase-1 Levels In Patients With Ischemic Heart Disease Undergoing Coronary Angiography, Mark Wilson, Dimitri Mikhailidis, Maria Poulakou, Despina Perrea, Kosmas Paraskevas, Dimitrios Iliopoulos, Serafim Tsitsilonis, Ioannis Vlachos, Sonia-Athena Karabina
Mark R Wilson
No abstract provided.
Carotenoid Intake Does Not Mediate A Relationship Between Reactive Oxygen Species And Bright Colouration: Experimental Test In A Lizard, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott
Carotenoid Intake Does Not Mediate A Relationship Between Reactive Oxygen Species And Bright Colouration: Experimental Test In A Lizard, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott
Mark R Wilson
No abstract provided.
Free Radicals Run In Lizard Families, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott, Mo Healey, Wanger Thomas
Free Radicals Run In Lizard Families, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott, Mo Healey, Wanger Thomas
Mark R Wilson
No abstract provided.
Comparison Of Virulence Gene Profiles Between Escherichia Coli Strains Isolated From Healthy And Diarrheic Swine, Mark Wilson, Karl A Bettelheim, X Y Wu, S Driesen, James Chin, Toni Chapman, I Barchia, D Trott
Comparison Of Virulence Gene Profiles Between Escherichia Coli Strains Isolated From Healthy And Diarrheic Swine, Mark Wilson, Karl A Bettelheim, X Y Wu, S Driesen, James Chin, Toni Chapman, I Barchia, D Trott
Mark R Wilson
No abstract provided.
Lymphotoxin-Beta Receptor-Dependent Genes In Lymph Node And Follicular Dendritic Cell Transcriptomes, Mark Wilson, C. Huber, C. Thielen, Y. Fu, E. Heinen, A Aguzzi, G Miele
Lymphotoxin-Beta Receptor-Dependent Genes In Lymph Node And Follicular Dendritic Cell Transcriptomes, Mark Wilson, C. Huber, C. Thielen, Y. Fu, E. Heinen, A Aguzzi, G Miele
Mark R Wilson
No abstract provided.
Detecting Mitochondrial Permeability Transition By Confocal Imaging Of Intact Cells Pinocytically Loaded With Calcein, Rachel Jones, Alison Smail, Mark Wilson
Detecting Mitochondrial Permeability Transition By Confocal Imaging Of Intact Cells Pinocytically Loaded With Calcein, Rachel Jones, Alison Smail, Mark Wilson
Mark R Wilson
When studied in vitro, mitochondrial permeability transition (MPT) is associated with an increase in mitochondrial permeability to solutes up to 1500 Da in mass and a loss of electrical potential difference across the inner mitochondrial membrane (delta psi mit). The MPT has been implicated as being important in cellular calcium homeostasis, autophagy and cell death via necrosis and apoptosis. Thus, it is important to develop a valid technique for accurate measurement of this phenomenon in intact cells. We developed a procedure for the detection of MPT in intact cells that avoids disadvantages associated with earlier approaches. In this new technique, …