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Full-Text Articles in Life Sciences

Intraretinal Signaling By Ganglion Cell Photoreceptors To Dopaminergic Amacrine Neurons, Dao-Qi Zhang, Kwoon Y. Wong, Patricia J. Sollars, David M. Berson, Gary E. Pickard, Douglas G. Mcmahon Sep 2008

Intraretinal Signaling By Ganglion Cell Photoreceptors To Dopaminergic Amacrine Neurons, Dao-Qi Zhang, Kwoon Y. Wong, Patricia J. Sollars, David M. Berson, Gary E. Pickard, Douglas G. Mcmahon

School of Veterinary and Biomedical Sciences: Faculty Publications

Retinal dopaminergic amacrine neurons (DA neurons) play a central role in reconfiguring retinal function according to prevailing illumination conditions, yet the mechanisms by which light regulates their activity are poorly understood. We investigated the means by which sustained light responses are evoked in DA neurons. Sustained light responses were driven by cationic currents and persisted in vitro and in vivo in the presence of L-AP4, a blocker of retinal ON-bipolar cells. Several characteristics of these L-AP4-resistant light responses suggested that they were driven by melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), including long latencies, marked poststimulus persistence, and a peak …


Regulation Of The Bioavailability Of Thioredoxin In The Lens By A Specific Thioredoxin-Binding Protein (Tbp-2), Namal P.M. Liyanage, M. Rohan Fernando, Marjorie F. Lou Aug 2008

Regulation Of The Bioavailability Of Thioredoxin In The Lens By A Specific Thioredoxin-Binding Protein (Tbp-2), Namal P.M. Liyanage, M. Rohan Fernando, Marjorie F. Lou

School of Veterinary and Biomedical Sciences: Faculty Publications

Thioredoxin (TRx) is known to control redox homeostasis in cells. In recent years, a specific TRx binding protein called thioredoxin binding protein-2 (TBP-2) was found in other cell types and it appeared to negatively regulate TRx bioavailability and thereby control TRx biological function. In view of the sensitivity of lens transparency to redox status, proper regulation of TRx bioavailability is of the utmost importance. This study was conducted to examine the presence and function of TBP-2 in human lens epithelial cells (HLE B3). We cloned human lens TBP-2 from a human cDNA library (GenBank accession number AY 594328) and showed …


Sheep Updates 2008 - Contents, Department Of Food And Agriculture, Western Australia Jul 2008

Sheep Updates 2008 - Contents, Department Of Food And Agriculture, Western Australia

Sheep Updates

No abstract provided.


Determinación De Resistencia Antihelmíntica Frente A Las Lactonas Macrocíclicas Por Parte De Nemátodos Gastrointestinales Del Equino Mediante El Test De Reducción De La Oviposición Fecrt En Los Municipios De Aguazul, El Yopal, Maní Y Paz De Ariporo Departamento Del Casanare, Erik Chaparro Salamanca Jan 2008

Determinación De Resistencia Antihelmíntica Frente A Las Lactonas Macrocíclicas Por Parte De Nemátodos Gastrointestinales Del Equino Mediante El Test De Reducción De La Oviposición Fecrt En Los Municipios De Aguazul, El Yopal, Maní Y Paz De Ariporo Departamento Del Casanare, Erik Chaparro Salamanca

Medicina Veterinaria

La presente investigación se llevó a cabo en los municipios de Aguazul, El Yopal, Maní y Paz de Ariporo, departamento del Casanare; el objetivo principal fue determinar los grados de resistencia o susceptibilidad antihelmíntica de parásitos gastrointestinales del equino, frente a las lactonas Macrocíclicas (Ivermectina) para lo cual se muestrearon 40 equinos (10 equinos por municipio), criollos dedicados a la reproducción en estado silvestre. A todos los animales se les tomó una muestra de materia fecal el día cero (antes del tratamiento con Ivermectina) y el día 14 (post tratamiento con Ivermectina) (Ivermectina comercial no genérico), estas muestras se procesaron …