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- Faculty of Health and Behavioural Sciences - Papers (Archive) (31)
- Faculty of Science - Papers (Archive) (20)
- Xu-Feng Huang (12)
- Karen E. Charlton (4)
- Jimmy Chun Yu Louie (3)
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- Qingsheng Zhang (3)
- Mark R Wilson (2)
- Don C. Iverson (1)
- Dr Paul J Stapley (1)
- Gordon Wallace (1)
- Harold Hill (1)
- Honors Projects (1)
- J. A. Aquilina (1)
- Jenny A Fisher (1)
- Journal of Police and Legal Sciences (1)
- Kim Lewis (1)
- Sandra Jones (1)
- Sharon Robinson (1)
- Shifting Baselines and New Meridians: Water, Resources, Landscapes, and the Transformation of the American West (Summer Conference, June 4-6) (1)
- The Past, Present, and Future of Our Public Lands: Celebrating the 40th Anniversary of the Public Land Law Review Commission’s Report, One Third of the Nation’s Land (Martz Summer Conference, June 2-4) (1)
- joseph Ciarrochi (1)
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Articles 1 - 30 of 89
Full-Text Articles in Life Sciences
Regulations And Effects Of Foreigners' Deportation Decisions A Comparative Study, Raad Alhammadin
Regulations And Effects Of Foreigners' Deportation Decisions A Comparative Study, Raad Alhammadin
Journal of Police and Legal Sciences
The aim of the study was to identify the procedural and objective legal principles specific to the deportation of foreigners that need to be considered within the legal framework of deportation. The study relied on a descriptive analytical approach, which involved observing, analyzing, and highlighting the elements of the subject. It concluded that the purpose of deporting foreigners is the state's right to expel non-citizens from its territory for reasons related to its internal or external security and in accordance with applicable laws. The regulations are considered safeguards to ensure the proper exercise of administrative authority in issuing deportation decisions …
Brief Report: Can Men Do Better If They Try Harder: Sex And Motivational Effects On Emotional Awareness, Joseph Ciarrochi, Nadia Crittenden, Keiren Hynes
Brief Report: Can Men Do Better If They Try Harder: Sex And Motivational Effects On Emotional Awareness, Joseph Ciarrochi, Nadia Crittenden, Keiren Hynes
joseph Ciarrochi
No abstract provided.
Effects Of Aging On Organic Aerosol From Open Biomass Burning Smoke In Aircraft And Laboratory Studies, M J. Cubison, A M. Ortega, P L. Hayes, D K. Farmer, D Day, M J. Lechner, W H. Brune, E Apel, G S. Diskin, J A. Fisher, H E. Fuelberg, A Hecobian, D J. Knapp, T Mikoviny, D Riemer, G W. Sachse, W Sessions, R Weber, A J. Weinheimer, A Wisthaler, J L. Jimenez
Effects Of Aging On Organic Aerosol From Open Biomass Burning Smoke In Aircraft And Laboratory Studies, M J. Cubison, A M. Ortega, P L. Hayes, D K. Farmer, D Day, M J. Lechner, W H. Brune, E Apel, G S. Diskin, J A. Fisher, H E. Fuelberg, A Hecobian, D J. Knapp, T Mikoviny, D Riemer, G W. Sachse, W Sessions, R Weber, A J. Weinheimer, A Wisthaler, J L. Jimenez
Jenny A Fisher
Biomass burning (BB) is a large source of primary and secondary organic aerosols (POA and SOA). This study addresses the physical and chemical evolution of BB organic aerosols. Firstly, the evolution and lifetime of BB POA and SOA signatures observed with the Aerodyne Aerosol Mass Spectrometer are investigated, focusing on measurements at high-latitudes acquired during the 2008 NASA ARCTAS mission, in comparison to data from other field studies and from laboratory aging experiments. The parameter f60 , the ratio of the integrated signal at m/z 60 to the total signal in the organic component mass spectrum, is used as a …
Determining The Critical Window Of Influence Of Pcb Perinatally On Behavioral And Hormonal Development In Sprague-Dawley Rat Pups, Natalie Sommerville, Lee A. Meserve, Howard C. Cromwell
Determining The Critical Window Of Influence Of Pcb Perinatally On Behavioral And Hormonal Development In Sprague-Dawley Rat Pups, Natalie Sommerville, Lee A. Meserve, Howard C. Cromwell
Honors Projects
Polychlorinated biphenyls (PCB) had widespread use in the United States in commercial manufacturing in the United States until the late 1970s. Even though they were banned, measurable amounts can still be found in the environment and food sources. PCB has known effects on altering hormone development and behavior in the species Rattus norvegicus. To determine the most crucial developmental time of exposure to PCB in Sprague-Dawley rat pups, rat pups were exposed to PCB at differing weeks of either gestation period or the first postnatal week. Behavioral tests were performed for the different rat pups, as well as blood …
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Appetite Regulatory Hormone Responses, Karen E. Charlton, Linda C. Tapsell, Marijka Batterham, Jane E. O'Shea, Rebecca L. Thorne, Qingsheng Zhang, Eleanor Beck
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Appetite Regulatory Hormone Responses, Karen E. Charlton, Linda C. Tapsell, Marijka Batterham, Jane E. O'Shea, Rebecca L. Thorne, Qingsheng Zhang, Eleanor Beck
Qingsheng Zhang
No abstract provided.
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck
Qingsheng Zhang
The effects of three different meat-containing breakfast meals (pork, beef or chicken) on acute satiety and appetite regulatory hormones were compared using a within-subjects study design. Thirty fasting non-smoking pre-menopausal women attended a research centre on three test days to consume, a meat-containing meal matched in energy (kJ) and protein content, palatability, and appearance. No difference was found between meat groups for either energy intake or macronutrient profile of food consume data subsequent ad libitum buffet lunch, or over the rest of the day. Visual Analogue Scale(VAS) ratings for hunger and satiety over an 180min period did not differ between …
Cholesterol-Lowering Effects Of B-Glucan Containing Breakfast Cereals And Snack Bars, Karen Charlton, Linda Tapsell, Marijka Batterham, Jane O'Shea, Rebecca Thorne, Qingsheng Zhang, Eleanor Beck
Cholesterol-Lowering Effects Of B-Glucan Containing Breakfast Cereals And Snack Bars, Karen Charlton, Linda Tapsell, Marijka Batterham, Jane O'Shea, Rebecca Thorne, Qingsheng Zhang, Eleanor Beck
Qingsheng Zhang
No abstract provided.
Independent Effects Of Local And Global Binocular Disparity On The Perceived Convexity Of Stereoscopically Presented Faces In Scenes, Harold Matthews, Harold Hill, Stephen Palmisano
Independent Effects Of Local And Global Binocular Disparity On The Perceived Convexity Of Stereoscopically Presented Faces In Scenes, Harold Matthews, Harold Hill, Stephen Palmisano
Harold Hill
No abstract provided.
Saving Lives Or Raising Revenue: Analysing Media Coverage Of The Alcopops Tax In Light Of The Evidence On Its Effects, Sandra C. Jones, Laura Robinson
Saving Lives Or Raising Revenue: Analysing Media Coverage Of The Alcopops Tax In Light Of The Evidence On Its Effects, Sandra C. Jones, Laura Robinson
Sandra Jones
The Australian Government increased the tax on ready-to-drink (RTD) alcohol beverages in 2008, in order to address concerns about increasing alcohol consumption among young people. This decision resulted in significant debate and discussion in the media, and in academic circles. The aim of the current study was to examine media coverage of the debate – and particularly the arguments posed in favour of and against the tax – now that we have objective evidence of its impact. We find that business owners and industry groups were vocal in the media, raising a number of arguments in opposition to the tax; …
Extracellular Chaperones Modulate The Effects Of Alzheimer's Patient Cerebrospinal Fluid On A Beta(1-42) Toxicity And Uptake , Justin J. Yerbury, Mark R. Wilson
Extracellular Chaperones Modulate The Effects Of Alzheimer's Patient Cerebrospinal Fluid On A Beta(1-42) Toxicity And Uptake , Justin J. Yerbury, Mark R. Wilson
Mark R Wilson
Alzheimer's disease is characterised by the inappropriate death of brain cells and accumulation of the A beta peptide in the brain. Thus, it is possible that there are fundamental differences between Alzheimer's disease patients and healthy individuals in their abilities to clear A beta from brain fluid and to protect neurons from A beta toxicity. In the present study, we examined (1) the cytotoxicity of Alzheimer's disease cerebrospinal fluid (CSF) compared to control CSF, (2) the ability of Alzheimer's disease and control CSF to protect cells from A beta toxicity and to promote cell-mediated clearance of A beta and lastly …
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Karen E. Charlton
Background and aims: Decreasing energy intake relative to energy expenditure is the indisputable tenet of weight loss. In addition to caloric restriction modification of the type of dietary fat may provide further benefits. The aim of the present study was to examine the effect of energy restriction alone and with dietary fat modification on weight loss and adiposity, as well as on risk factors for obesity related disease. Methods and results: One-hundred and fifty overweight men and women were randomized into a 3 month controlled trial with four low fat (30% energy) dietary arms: (1) isocaloric (LF); (2) isocaloric with …
Long-Term Effects Of Increased Dietary Polyunsaturated Fat From Walnuts On Metabolic Parameters In Type Ii Diabetes, Cassandra Quick, Marijka Batterham, Linda Tapsell, Lynda Gillen, Karen Charlton, Sze Yen Tan, Grigorijs Teuss, Sayne Mam Dalton
Long-Term Effects Of Increased Dietary Polyunsaturated Fat From Walnuts On Metabolic Parameters In Type Ii Diabetes, Cassandra Quick, Marijka Batterham, Linda Tapsell, Lynda Gillen, Karen Charlton, Sze Yen Tan, Grigorijs Teuss, Sayne Mam Dalton
Karen E. Charlton
Background/Objectives: Most dietary interventions have metabolic effects in the short term, but long-term effects may require dietary fat changes to influence body composition and insulin action. This study assessed the effect of sustained high polyunsaturated fatty acids (PUFA) intake through walnut consumption on metabolic outcomes in type II diabetes.Subjects/Methods: Fifty overweight adults with non-insulin-treated diabetes (mean age 54±8.7 years) were randomized to receive low-fat dietary advice ±30 g per day walnuts targeting weight maintenance (around 2000 kcal, 30% fat) for 1 year. Differences between groups were assessed by changes in anthropometric values (body weight, body fat, visceral adipose tissue) and …
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Appetite Regulatory Hormone Responses, Karen E. Charlton, Linda C. Tapsell, Marijka Batterham, Jane E. O'Shea, Rebecca L. Thorne, Qingsheng Zhang, Eleanor Beck
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Appetite Regulatory Hormone Responses, Karen E. Charlton, Linda C. Tapsell, Marijka Batterham, Jane E. O'Shea, Rebecca L. Thorne, Qingsheng Zhang, Eleanor Beck
Karen E. Charlton
No abstract provided.
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck
Karen E. Charlton
The effects of three different meat-containing breakfast meals (pork, beef or chicken) on acute satiety and appetite regulatory hormones were compared using a within-subjects study design. Thirty fasting non-smoking pre-menopausal women attended a research centre on three test days to consume, a meat-containing meal matched in energy (kJ) and protein content, palatability, and appearance. No difference was found between meat groups for either energy intake or macronutrient profile of food consume data subsequent ad libitum buffet lunch, or over the rest of the day. Visual Analogue Scale(VAS) ratings for hunger and satiety over an 180min period did not differ between …
Remarkable Synergistic Effects In A Mixed Porphyrin Dye-Sensitized Tio2 Film, Attila J. Mozer, Gordon G. Wallace, David L. Officer, Matthew Griffith, Pawel W. Wagner, Klaudia K. Wagner, George Tsekouras, Shogo Mori, Ying Dong
Remarkable Synergistic Effects In A Mixed Porphyrin Dye-Sensitized Tio2 Film, Attila J. Mozer, Gordon G. Wallace, David L. Officer, Matthew Griffith, Pawel W. Wagner, Klaudia K. Wagner, George Tsekouras, Shogo Mori, Ying Dong
Gordon Wallace
A remarkable 300% efficiency enhancement driven by a matching increase in the short circuit current was observed in a mixed porphyrin dye-sensitized solar cell constructed from two dyes in a 3:1 ratio. Absorbed photon-to-current conversion efficiency measurements indicate an improved charge injection yield for both dyes in the mixture. Several possible origins for the observed performance enhancement are discussed.
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Xu-Feng Huang
Antipsychotic drugs have various neuropharmacological properties as a result of their structural diversity. Despite their therapeutic benefits, most of the prescribed atypical antipsychotics can induce severe side effects, including weight gain, type II diabetes mellitus, and cardiovascular diseases. Among the developed atypical antipsychotic agents, tetracyclic dibenzodiazepine and thienobenzodiazepine compounds, particularly clozapine and olanzapine, are associated with the greatest weight gain and metabolic disturbances. However, the unique chemical structure of these compounds causes the low risk of side effects reported for typical antipsychotics (e.g. extrapyramidal symptoms and tardive dyskinesia). This report reviews the recent discovery of the potential role of the …
Effects Of Ice Hockey Facial Protectors On The Response Time And Kinematics In Goal-Directed Tasks, P M. Dowler, D J. Pearsall, P J. Stapley
Effects Of Ice Hockey Facial Protectors On The Response Time And Kinematics In Goal-Directed Tasks, P M. Dowler, D J. Pearsall, P J. Stapley
Dr Paul J Stapley
Ice hockey facial protectors are essential to prevent eye (and, in some cases, dental) injuries but must also not encumber vision and, in turn, playersapos; performance. The purpose of this study was to investigate the effects of three different facial protection conditions on temporal and kinematic parameters in a goal-directed pointing task: helmet (control), visor, and cage. Start and end target switches captured temporal estimates (reaction time (RT), movement time, (MT), and response time (RT+MT)), while a 13-light target array and 6-camera Vicon Mx system were used to collect upper-body kinematics data (head and thorax orientation, shoulder and elbow joint …
A Randomized Controlled Trial Investigating The Effects Of A Low-Glycemic Index Diet On Pregnancy Outcomes In Gestational Diabetes Mellitus, Jennie Brand-Miller, Jimmy Chun Yu Louie, Peter Petocz, Tania Markovic, Nimalie Perera, Deborah Foote, Glynis Ross
A Randomized Controlled Trial Investigating The Effects Of A Low-Glycemic Index Diet On Pregnancy Outcomes In Gestational Diabetes Mellitus, Jennie Brand-Miller, Jimmy Chun Yu Louie, Peter Petocz, Tania Markovic, Nimalie Perera, Deborah Foote, Glynis Ross
Jimmy Chun Yu Louie
OBJECTIVE: The prevalence of gestational diabetes mellitus (GDM) is rising. There is little evidence to demonstrate the effectiveness of one dietary therapy over another. We aimed to investigate the effect of a low-glycemic index (LGI) versus a conventional high-fiber diet on pregnancy outcomes, neonatal anthropometry, and maternal metabolic profile in GDM.RESEARCH DESIGN AND METHODS: Ninety-nine women (age 26-42 years; mean ñ SD prepregnancy BMI 24 ñ 5 kg/mò) diagnosed with GDM at 20-32 weeks' gestation were randomized to follow either an LGI (n = 50; target glycemic index [GI] ~50) or a high-fiber moderate-GI diet (HF) (n = 49; target …
"A Spoonful Of Sugar": Delayed Effects Of Coffee, Tea And Sucrose On Postprandial Glycemia In Lean, Young, Healthy Adults, Jimmy Chun Yu Louie, F Atkinson, P Petocz, J Brand-Miller
"A Spoonful Of Sugar": Delayed Effects Of Coffee, Tea And Sucrose On Postprandial Glycemia In Lean, Young, Healthy Adults, Jimmy Chun Yu Louie, F Atkinson, P Petocz, J Brand-Miller
Jimmy Chun Yu Louie
No abstract provided.
Delayed Effects Of Coffee, Tea And Sucrose On Postprandial Glycemia In Lean, Young, Healthy Adults, Jimmy Chun Yu Louie, Fiona Atkinson, Peter Petocz, Jennie Brand-Miller
Delayed Effects Of Coffee, Tea And Sucrose On Postprandial Glycemia In Lean, Young, Healthy Adults, Jimmy Chun Yu Louie, Fiona Atkinson, Peter Petocz, Jennie Brand-Miller
Jimmy Chun Yu Louie
In observational studies, habitual coffee consumption has been linked to a lower risk of type 2 diabetes. We hy-pothesized that the mechanism may be related to delayed effects on postprandial glycemia. The aim of this study is to investigate the glycemic and insulinemic effects of consumption of caffeinated and decaffeinated coffee, sweetened and unsweetened, tea and sucrose, 1 h prior to a high carbohydrate meal. On separate occasions in random order, lean young healthy subjects (n = 8) consumed a potato-based meal 1 hour after consumption of 250 mL of black coffee (COF), black coffee sweetened with 10 g of …
Effects Of Glycosylation On The Structure And Function Of The Extracellular Chaperone Clusterin, Elise Stewart, Andrew Aquilina, Simon B Easterbrook-Smith, D Murphy-Durland, C Jacobsen, S Moestrup, Mark Wilson
Effects Of Glycosylation On The Structure And Function Of The Extracellular Chaperone Clusterin, Elise Stewart, Andrew Aquilina, Simon B Easterbrook-Smith, D Murphy-Durland, C Jacobsen, S Moestrup, Mark Wilson
J. A. Aquilina
Clusterin is the first well characterized, constitutively secreted extracellular chaperone that binds to exposed regions of hydrophobicity on non-native proteins. It may help control the folding state of extracellular proteins by targeting them for receptor-mediated endocytosis and intracellular lysosomal degradation. A notable feature of secreted clusterin is its heavy glycosylation. Although carbohydrate comprises approximately 20−25% of the total mass of the mature molecule, its function is unknown. Results from the current study demonstrate that deglycosylation of human serum clusterin had little effect on its overall secondary structure content but produced a small increase in solvent-exposed hydrophobicity and enhanced the propensity …
Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang
Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang
Xu-Feng Huang
No abstract provided.
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
Xu-Feng Huang
Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with the synthetic analogue of D9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We measured the impact of this exposure on locomotor activity, anxiety, prepulse inhibition (PPI), body temperature and FosB/DFosB immunohistochemistry. Tolerance to CP55,940-induced hypothermia and locomotor suppression developed more rapidly in Nrg1 HET mice than WT mice. Conversely in the light-dark test, while tolerance to …
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Xu-Feng Huang
The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats treated with three types of antipsychotics. Rats were divided into eight groups and treated with aripiprazole (2.25mg/kg/day), olanzapine (1.5mg/kg/day), haloperidol (0.3mg/kg/day) or vehicle (as control) for 1 or 12 weeks. Administration of olanzapine for 1 week led to a threefold increase in body weight gain and a 35% increase in fat deposits compared to controls (p<0.05). In the 12-week olanzapine treatment group, accumulative food intake was significantly higher in the first 7 weeks of treatment compared to …
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Xu-Feng Huang
Background and aims: Decreasing energy intake relative to energy expenditure is the indisputable tenet of weight loss. In addition to caloric restriction modification of the type of dietary fat may provide further benefits. The aim of the present study was to examine the effect of energy restriction alone and with dietary fat modification on weight loss and adiposity, as well as on risk factors for obesity related disease. Methods and results: One-hundred and fifty overweight men and women were randomized into a 3 month controlled trial with four low fat (30% energy) dietary arms: (1) isocaloric (LF); (2) isocaloric with …
Effects Of Diets High In Whey, Soy, Red Meat And Milk Protein On Body Weight Maintenance In Diet-Induced Obesity In Mice, Xu-Feng Huang, Y Liu, Gita Rahardjo, Peter Mclennan, Linda Tapsell, William Buttemer
Effects Of Diets High In Whey, Soy, Red Meat And Milk Protein On Body Weight Maintenance In Diet-Induced Obesity In Mice, Xu-Feng Huang, Y Liu, Gita Rahardjo, Peter Mclennan, Linda Tapsell, William Buttemer
Xu-Feng Huang
This study examined the effects of different food sources of protein on energy intake, body weight maintenance, and on the responses of plasma leptin, insulin and adiponectin in chronic high-fat diet-induced obese mice. Obesity was induced in 47 mice with a high-fat diet for 20 weeks. They were divided into five diet groups to test the effects of a higher protein proportion (30% energy), achieved at the expense of carbohydrate. For the next eight weeks, four of the groups were fed diets of chow formulated with whey, soy, red meat or milk while the control group continued on their high-fat …
Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han
Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han
Xu-Feng Huang
Aripiprazole has been used effectively to treat schizophrenia in the clinic ; however, its mechanisms ofaction are not clear. This study examined how short- and long-term aripiprazole treatment affects dopaminergic transmission in mesolimbic and nigrostriatal pathways. For comparison, the effects of haloperidol and olanzapine treatment were also examined. Aripiprazole significantly increased D2 receptor mRNA expression and decreased tyrosine hydroxylase (TH) mRNA expression in the ventral tegmental area (VTA) after 1- and 12-wk treatment, but had no effect in substantia nigra (SN) and nucleus accumbens (NAc). Aripiprazole also decreased dopamine transporter (DAT) binding density in NAc (for 1- and 12- wk …
Effects Of Chronic Treatment Of Olanzapine And Haloperidol On Peptide Yy Binding Densities In The Rat Brain, Xu-Feng Huang, Qing Wang
Effects Of Chronic Treatment Of Olanzapine And Haloperidol On Peptide Yy Binding Densities In The Rat Brain, Xu-Feng Huang, Qing Wang
Xu-Feng Huang
This study examined regional changes of peptide YY (PYY) binding densities in the rat brain after chronic administration of olanzapine (1.2 mg/kg/day and haloperidol (2.0 mg/kg/day)for 36 days. PYY binding densities and distributions were detected by [125I] binding autoradiography after ratswere sacrificed either 2 h or 48 h after the last drug administration to examine both immediate and delayed effects following the drugwithdrawal. Following 2 h of drug administration, it showed that olanzapine administration significantly decreased PYY binding densities, predominantly in the posterodorsal part of medial amygdaloid nucleus (52 percent, pb0.05), dorsal part of medial geniculate nucleus (56 percent, pb0.05), …
Effects Of Antipsychotic Medication On Muscarinic M1 Receptor Mrna Expression In The Rat Brain, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Chao Deng, Mei Han
Effects Of Antipsychotic Medication On Muscarinic M1 Receptor Mrna Expression In The Rat Brain, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Chao Deng, Mei Han
Xu-Feng Huang
Alterations in muscarinic M1 receptor protein and mRNA expression have been revealed in post-mortem brains of schizophrenia patients. Most patients had been treated with antipsychotics, so medication effects cannot be excluded as a possible explanation for these results. With in situ hybridization, this study investigated M1 receptor mRNA expression in rats treated with the typical antipsychotic haloperidol (0.3 mg/kg/day) and the atypical antipsychotics olanzapine (1.5 mg/kg/day) and aripiprazole (2.25 mg/kg/day) for 1 or 12 weeks. Compared with the control group, haloperidol significantly increased (13-21%, P < 0.05) M1 mRNA expression in the CA1, CA2, and CA3 regions of the hippocampus after both 1 and 12 weeks of treatment, and it also increased (17%, P < 0.01) M1 mRNA expression in the substantia nigra compacta after 1 week of treatment. Olanzapine significantly increased (14-22%, P < 0.05) M1 mRNA expression in the hippocampus (CA1, CA2, and CA3) and substantia nigra compacta after 12 weeks of treatment, but not after 1 week. Aripiprazole significantly increased (17%, P < 0.01) M1 mRNA expression in the hippocampus (CA1) after both 1 and 12 week treatments and increased (12%, P < 0.05) M1 mRNA expression in the nucleus accumbens after 1 week of treatment. Despite their different affinities for muscarinic M1 receptors, all three antipsychotic medications induced a similar trend of change in M1 mRNA expression in selected brain regions. These data suggest that the decreased M1 receptor protein and mRNA expression observed in schizophrenia patients is unlikely to be a consequence of drug treatments and implicates muscarinic M1 receptors in the pharmacotherapy of the disease. ÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂé 2007 Wiley-Liss, Inc.
Opposing Short- And Long-Term Effects On Muscarinic M1/4 Receptor Binding Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Opposing Short- And Long-Term Effects On Muscarinic M1/4 Receptor Binding Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Xu-Feng Huang
No abstract provided.