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Articles 211 - 223 of 223

Full-Text Articles in Life Sciences

Intracellular Coexpression Of Epidermal Growth Factor Receptor, Her-2/Neu, And P21ras In Human Breast Cancers: Evidence For The Existence Of Distinctive Patterns Of Genetic Evolution That Are Common To Tumors From Different Patients, Stanley E. Shackney, Agnese A. Pollice, Charles A. Smith, Laura E. Janocko, Lillian Sweeney, Kathryn A. Brown, Sarita G. Singh, Lingping Gu, Robert Yakulis, Joseph F. Lucke Jan 1998

Intracellular Coexpression Of Epidermal Growth Factor Receptor, Her-2/Neu, And P21ras In Human Breast Cancers: Evidence For The Existence Of Distinctive Patterns Of Genetic Evolution That Are Common To Tumors From Different Patients, Stanley E. Shackney, Agnese A. Pollice, Charles A. Smith, Laura E. Janocko, Lillian Sweeney, Kathryn A. Brown, Sarita G. Singh, Lingping Gu, Robert Yakulis, Joseph F. Lucke

Joseph Lucke

Multiparameter flow cytometry studies were performed on cells from the primary tumors of 94 patients with breast cancer. Correlated cellular measurements of cell DNA content, Her-2/neu, epidermal growth factor receptor (EGFR), and p21ras levels were performed on each of 5,000 to 100,000 cells from each tumor. When criteria for positivity were matched with those in common use for immunohistochemical studies, 28 of 94 (30\%) breast cancers were classified as positive for Her-2/neu overexpression. When similar criteria were applied to the EGFR measurements, 23 of 94 (24\%) cases were classified as positive for EGFR overexpression. Similarly, 23 of 94 (24\%) cases …

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Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney Jan 1995

Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney

Joseph Lucke

Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in breast cancer. The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers. The data suggested a preferred sequence of amplification that consisted of c-myc amplification-HER-2/neu amplification-H-ras amplification. This model was supported by loglinear analysis. In addition, the levels of amplification of JC-A, a …

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A Memorable Meeting, February 1994, Fathi Habashi Feb 1994

A Memorable Meeting, February 1994, Fathi Habashi

Fathi Habashi

Decision taken at the Steering Committee Meeting of the International Mineral Processing Congress in San Francisco February 1994 to name the IMPC Award.

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The Hazardous Waste Land, Jerry L. Anderson Nov 1993

The Hazardous Waste Land, Jerry L. Anderson

Jerry L. Anderson

This article was one of the first comprehensive critiques of the Superfund remediation and liability system. The article addresses systemic problems with the CERCLA mechanism that result in inequity and slow the pace of cleanups.

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Functional Explanation And Metaphysical Individualism, Justin Schwartz Jan 1993

Functional Explanation And Metaphysical Individualism, Justin Schwartz

Justin Schwartz

A number of (present or former) analytical Marxists, such as Jon Elster, have argued that functional explanation has almost no place in the social sciences. (Although the discussion is framed in terms of a debate among analytical Marxists, the point is quite general, and Marxism is used for illustrative purposes.) Functional explanation accounts for what is to be explained by reference to its function; thus, sighted organism have eyes because eyes enable them to see. Elster and other critics of functional explanation argue that this pattern of explanation is inconsistent with "methodological individualism," the idea, as they understand it, that …

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The Saurian Psyche Revisted: Lizards In Research, Neil Greenberg Jan 1992

The Saurian Psyche Revisted: Lizards In Research, Neil Greenberg

Neil Greenberg

This essay is intended to guide researchers interested in lizards as prospective experimental models to identify an appropriate species for their research needs and to care for lizards in a manner that will not compromise their utility. Coupled with these is a concern for critical thinking about the ethical dimension of lizard research, one guide for which is to consider the intersection of human needs and lizard needs. Before proceeding further, several arbitrary premises must be made clear: 1. While wholly deserving of study because of their intrinsic interest, I will assume that the lizard research to be undertaken is …

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Forest Gardens Of The Maya, David A. Bainbridge Jan 1988

Forest Gardens Of The Maya, David A. Bainbridge

David A Bainbridge

The lowland Maya supported very high populations in an area with limited water and soil. Much can be learned from studying their sophisticated management practices. Forest gardens and agroforestry helped provide key nutrients, materials, and inputs for improved soil.

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Art, Science, Areté, Neil Greenberg Jan 1988

Art, Science, Areté, Neil Greenberg

Neil Greenberg

No abstract provided.

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Hidrometalurjide Yeni, Fathi Habashi Jan 1979

Hidrometalurjide Yeni, Fathi Habashi

Fathi Habashi

Turkish translation of F. Habashi, “Recent Advances in Hydrometallurgy,” Proceedings International Mineral Processing Congress, Warsaw, 1979, edited by J. Laskowski, published by Elsevier, pp. 902–935

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Breadbox Water Heater Designs, David A. Bainbridge Jan 1978

Breadbox Water Heater Designs, David A. Bainbridge

David A Bainbridge

Integral solar water heaters (batch, breadbox, ICS) provide the most economical and reliable means of heating water. Simple designs can perform well and provide service for decades. Basic design principles include box insulation, orientation and control of heat loss.

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Ethological Considerations In The Experimental Study Of Lizard Behavior, Neil Greenberg Jan 1978

Ethological Considerations In The Experimental Study Of Lizard Behavior, Neil Greenberg

Neil Greenberg

The importance of an ethological approach to the experimental study of an unfamiliar species is described and several of its problems discussed. The selection of units of behavior is a crucial first step in the development of a behavior inventory. The correlation of a behavioral unit with a particular context is necessary to ascribe function to that to that unit and to develop an ethogram. Methods of studying lizards under controlled conditions are described and discussed. Constraints on behavior that must be considered in an experimental study include the microclimate and its thermal qualities, food and water, shelter utilization, and …

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Planning For Energy Conservation, David A. Bainbridge Jan 1976

Planning For Energy Conservation, David A. Bainbridge

David A Bainbridge

City planning can provide multiple benefits by considering energy conservation, solar orientation and local resource harvesting. Narrower streets reduce construction costs, reduce urban heat island impacts and are safer. Above ground drainage reduces costs and returns rainwater to groundwater.

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Progress In Extractive Metallurgy, Volume 1. Review By G.N. Dobrokhotov, Fathi Habashi Jan 1975

Progress In Extractive Metallurgy, Volume 1. Review By G.N. Dobrokhotov, Fathi Habashi

Fathi Habashi

Review of the first volume of Progress in Extractive Metallurgy edited by Fathi Habashi and published by Gordon & Breach in New York in 1975. The review was written by Professor Dobrokhotov at the Leningrad Mining Institute.

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