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Full-Text Articles in Life Sciences

Darwinism Evolving: Systems Dynamics And The Genealogy Of Natural Selection, David Depew, Bruce Weber Dec 1994

Darwinism Evolving: Systems Dynamics And The Genealogy Of Natural Selection, David Depew, Bruce Weber

David J Depew

Darwinism Evolving examines the Darwinian research tradition in evolutionary biology from its inception to its turbulent present, arguing that recent advances in modeling the nonlinear dynamics of complex systems may well catalyze the next major phase of Darwinian evolutionism.While Darwinism has successfully resisted reduction to physics, the authors point out that it has from the outset developed and applied its core explanatory concept, natural selection, by borrowing models from dynamics, a branch of physics. The recent development of complex systems dynamics may afford Darwinism yet another occasion to expand its explanatory power.Darwinism's use of dynamical models has received insufficient attention …


Evolution, Ethics, And The Complexity Revolution, David Depew, Bruce Weber Dec 1994

Evolution, Ethics, And The Complexity Revolution, David Depew, Bruce Weber

David J Depew

No abstract provided.


Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney Dec 1994

Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney

Charles Kay Smith

Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in breast cancer. The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers. The data suggested a preferred sequence of amplification that consisted of c-myc amplification-HER-2/neu amplification-H-ras amplification. This model was supported by loglinear analysis. In addition, the levels of amplification of JC-A, a …


Significant Differences: The Construction Of Knowledge, Objectivity, And Dominance, Donna M. Hughes Dr. Dec 1994

Significant Differences: The Construction Of Knowledge, Objectivity, And Dominance, Donna M. Hughes Dr.

Donna M. Hughes

The scientific method is a tool for the construction and justification of dominance in the world. The invention of statistics was a major methodological advance in the descriptive sciences causing a shift from descriptive analysis to mathematical analysis. The new methodological techniques were invented by men who were interested in explaining the inheritance of traits in order to support their political ideology of natural human superiority and inferiority. The statistical techniques transformed the scientific method and resulted in a process that constructs knowledge and establishes "significant differences" between the dominant group as the norm and the subordinate group as the …


Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney Dec 1994

Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney

Charles Kay Smith

Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in breast cancer. The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers. The data suggested a preferred sequence of amplification that consisted of c-myc amplification-HER-2/neu amplification-H-ras amplification. This model was supported by loglinear analysis. In addition, the levels of amplification of JC-A, a …