Life Sciences Commons^™

Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney

Joseph Lucke

Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in breast cancer. The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers. The data suggested a preferred sequence of amplification that consisted of c-myc amplification-HER-2/neu amplification-H-ras amplification. This model was supported by loglinear analysis. In addition, the levels of amplification of JC-A, a …

Chivalry In Pholcid Spiders Revisited, Julie A. Blanchong, Michael S. Summerfield, Mary A. Popson, Elizabeth M. Jakob

Julie A. Blanchong

Cohabiting pairs of adult spiders are likely to interact over prey, and the outcome of these interactions is likely to affect the reproductive success of both individuals. In two species of pholcid spiders, previous workers reported the occurrence of "chivalrous" behavior, in which males cede prey to females. We looked for the occurrence of chivalrous behavior in another pholcid spider, Holocnemus pluchei. Pairs of spiders were placed on a web and left overnight without prey. A housefly was then introduced onto the web equidistant from the spiders, and subsequent interactions were noted on audiotape. We found no evidence of chivalry …

Localization Of Dopamine Receptor Subtypes Occupied By Intra-Accumbens Administration Of Selective Antagonists That Reverse Cocaine-Induced Locomotion., Laura O'Dell

Laura Elena O'Dell

No abstract provided.

Darwinism Evolving: Systems Dynamics And The Genealogy Of Natural Selection, David Depew, Bruce Weber

David J Depew

Darwinism Evolving examines the Darwinian research tradition in evolutionary biology from its inception to its turbulent present, arguing that recent advances in modeling the nonlinear dynamics of complex systems may well catalyze the next major phase of Darwinian evolutionism.While Darwinism has successfully resisted reduction to physics, the authors point out that it has from the outset developed and applied its core explanatory concept, natural selection, by borrowing models from dynamics, a branch of physics. The recent development of complex systems dynamics may afford Darwinism yet another occasion to expand its explanatory power.Darwinism's use of dynamical models has received insufficient attention …

Evolution, Ethics, And The Complexity Revolution, David Depew, Bruce Weber

David J Depew

No abstract provided.

Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney

Charles Kay Smith

Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in breast cancer. The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers. The data suggested a preferred sequence of amplification that consisted of c-myc amplification-HER-2/neu amplification-H-ras amplification. This model was supported by loglinear analysis. In addition, the levels of amplification of JC-A, a …

Significant Differences: The Construction Of Knowledge, Objectivity, And Dominance, Donna M. Hughes Dr.

Donna M. Hughes

Assessing Sequential Oncogene Amplification In Human Breast Cancer, Laura E. Janocko, Joseph F. Lucke, David W. Groft, Kathryn A. Brown, Charles A. Smith, Agnese A. Pollice, Sarita G. Singh, Robert Yakulis, Robert J. Hartsock, Stanley E. Shackney

Charles Kay Smith

Studies of amplification and/or overexpression of c-myc, HER-2/neu, and H-ras in breast cancer have shown that each is associated with a poor prognosis. The purpose of this study was to explore the possibility that there is a preferred sequence of amplification of these oncogenes in breast cancer. The frequencies of amplification and patterns of co-amplification of c-myc, HER-2/neu, and H-ras were studied in a group of 84 breast cancers. The data suggested a preferred sequence of amplification that consisted of c-myc amplification-HER-2/neu amplification-H-ras amplification. This model was supported by loglinear analysis. In addition, the levels of amplification of JC-A, a …