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Articles 1 - 10 of 10
Full-Text Articles in Life Sciences
Characterizing Cellular Stress, Hippocampal Function, And Behavior In A Novel Rat Model Of Alzheimer's Disease, Anne A. Schulman
Characterizing Cellular Stress, Hippocampal Function, And Behavior In A Novel Rat Model Of Alzheimer's Disease, Anne A. Schulman
Honors Theses
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that affects over 5 million individuals in the United States alone. While AD is primarily thought of as a disease that destroys neural networks required for memory recall and formation, AD also cause impairment in emotional regulation, cognitive flexibility, and executive function pathways. The cause of AD is unknown; however, the allele ApoE4 has been identified as a risk factor for the onset of AD. ApoE4 provides a valuable opportunity to study AD through animal models. This thesis utilized a human ApoE4 transgenic rat model (hApoE4) to investigate the biological and behavioral …
Community Interventions To The Food Insecurity Crisis Inuit Currently Face In Nunangat, Alyssia R. Getschow
Community Interventions To The Food Insecurity Crisis Inuit Currently Face In Nunangat, Alyssia R. Getschow
Honors Theses
Inuit living in Nunangat, a northern territory in Canada, are facing unprecedented rates of food insecurity. The increasing impacts of anthropogenic climate change are rapidly changing the Arctic landscape in Nunangat, posing challenges to Inuit hunters who hunt and live completely self-sufficient off of the land. This lack of access to country foods and the impacts these conditions are having on Inuit communities are forcing Inuit to consider aid propositions from the Canadian government. Due to a long history of conflict with white settlers during the colonization of Canada, there is a feeling of distrust and cultural distaste between Canada …
Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray
Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray
Honors Theses
Choline is an essential dietary nutrient essential to the development and function of the central nervous system. Prenatal choline deficiency alters hippocampal development as well as acetylcholine metabolism, leading to cognitive impairments and attentional and sensory processing deficits into adulthood. MK-801 is an NMDA receptor antagonist frequently used in rodent models of neuropsychiatric conditions, particularly schizophrenia. Acutely and sub- chronically, it causes hyperlocomotion and social withdrawal. One primary goal of the present study were to investigate prenatal choline deficiency induces a biological vulnerability to the motor deficits, anhedonia, and social impairment precipitated by low-dose sub-chronic MK-801 administration in adulthood. Another …
Executive Function Deficit As A Precursor To Memory Impairments In Hapoe4 Transgenic Rats, Kaitlin Mcmanus
Executive Function Deficit As A Precursor To Memory Impairments In Hapoe4 Transgenic Rats, Kaitlin Mcmanus
Honors Theses
The hApoE4 allele is one of the strongest genetic risk factors for Alzheimer’s disease (AD). It underlies amyloid-bdeposits and neurofibrillary tangles, the two hallmarks associated with AD pathology, and is subsequently associated with AD symptomology. Despite its importance, no rat animal studies to date use hApoE4 knock-ins. In addition to this deficit in the field of AD literature, the vast majority of AD studies focus on memory, even though executive function deficits may precede memory impairments in AD, and may be a predictor of AD development. Thus, the present study addressed these gaps in AD research by investigating the behavioral …
Crops And Controversy: Industry’S Role In The Gmo Debate, Carina Wallack
Crops And Controversy: Industry’S Role In The Gmo Debate, Carina Wallack
Honors Theses
The use of genetically modified crops (also called GM crops, genetically modified organisms, or GMOs for short) has become a highly contested issue. New genetic modification technologies offer a variety of advantages for improving agricultural efficiency. However, some scientists argue that the safety testing conducted thus far does not provide enough information and worry about possible health and ecological risks. Private industry sponsors a great deal of research on genetically modified crops. As the international controversy regarding the use of GMOs has unfolded, the very companies responsible for commercializing genetically modified crops have gained substantial influence in the resulting scientific …
Global Reach, Local Markets: The Challenges Of Leading Global Innovation, Sarah Higgins
Global Reach, Local Markets: The Challenges Of Leading Global Innovation, Sarah Higgins
Honors Theses
This Global Studies honors thesis addresses how managers and leaders of global firms manage innovation across multiple markets. Current research on multinational corporations provides an understanding of different kinds of innovation and the ways to attend to multiple markets. However, there is less documentation of how these innovation strategies are actually implemented on the ground and the tensions that these efforts might produce. Therefore, my research focuses in particular on the challenges and tensions faced by leaders of global firms as they implement transnational innovation strategies. This study is based upon in-depth interviews with 20 participants who held positions in …
The Impact Of Endocrine-Disrupting Chemicals On Wildlife Conservation, Eda Reed
The Impact Of Endocrine-Disrupting Chemicals On Wildlife Conservation, Eda Reed
Honors Theses
Endocrine-disrupting chemicals (EDCs), such as those from plastics and pesticides, have been hypothesized to affect wildlife populations. According to the U.S. National Institute of Environmental Health Sciences, EDCs ‘are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife.’ A growing number of studies suggest wildlife are being exposed to EDCs, but how EDCs affect wildlife health and wildlife conservation is less well-understood. Through scientific literature analysis and a survey of wildlife conservationists and practitioners, this study aims to determine the current state of knowledge and data …
School Gardens: Cultivating A Child’S Nutritional Habits, Environmental Knowledge, And Sustainability Practices, Jeffrey Meltzer
School Gardens: Cultivating A Child’S Nutritional Habits, Environmental Knowledge, And Sustainability Practices, Jeffrey Meltzer
Honors Theses
School gardens have existed since the late nineteenth century and today are becoming increasingly popular in many parts of the world, including where I studied in Maine and Australia (AUS). Multiple organizations support school gardens in Maine, including the Maine School Garden Network, which has over 125 registered school gardens. In AUS, the Stephanie Alexander Kitchen Garden Foundation primarily supports the school garden movement and has over 800 registered school gardens. While many researchers have studied school gardens, few have compared two countries, focused on environmental sustainability, or investigated Maine in particular. This thesis combines information from literature reviews, and …
The Role Of Underutilized Fish In New England's Seafood System, Taylor Witkin
The Role Of Underutilized Fish In New England's Seafood System, Taylor Witkin
Honors Theses
The global fisheries crisis has led to an increasing recognition for the need to relieve pressure on overfished, popular food fish stocks. Opportunities exist to shift consumer demand toward more sustainable choices, including fish that may be locally abundant. Attempts have been made to market underused fish (sometimes termed “trash fish”) that represent more sustainable alternatives; however, it is unclear whether consumers will choose to purchase these more sustainable options, particularly if underused fish are also unfamiliar. Chapter 1 reviews existing research and current issues surrounding sustainable seafood and the recent shift toward local, abundant, undervalued species in New England’s …
Family Ties: Mainstream Environmentalists' Understanding Of Radical Environmentalism In America, Zachary W. Ezor
Family Ties: Mainstream Environmentalists' Understanding Of Radical Environmentalism In America, Zachary W. Ezor
Honors Theses
Environmentalism in the United States manifests itself in numerous ways. While American environmentalists have been grouped into broad camps over the years, observers have struggled to accurately classify the different components of the movement. Lately, environmentalists have been characterized based on their chosen modus operandi. Environmentalists who employ typical interest group tactics of policy advocacy and accept the notion of political compromise can generally be called 'mainstream.' Alternatively, those environmentalists who employ non-conventional strategies like direct action and take a no-compromise stance on environmental issues are typically described as 'radical.' Despite these distinctions, both radical and mainstream environmentalists are parts …