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Full-Text Articles in Life Sciences
Changes In Hepatic Extracellular Matrix During The Development Of Cancer-Cachexia In Mice, Kyle Turner
Changes In Hepatic Extracellular Matrix During The Development Of Cancer-Cachexia In Mice, Kyle Turner
Health, Human Performance and Recreation Undergraduate Honors Theses
CHANGES IN HEPATIC EXTRACELLULAR MATRIX DURING THE DEVELOPMENT OF CANCER-CACHEXIA IN MICE
Turner K.W.1, Rosa-Caldwell M.E.1, Brown J.L.1, Lee D.E.1, Perry R.A.1, Haynie W.A.1 Washington T.A.1, Wiggs M.P.2, Greene N.P.1: 1University of Arkansas, Fayetteville, Arkansas; 2Univeristy of Texas at Tyler, Tyler, Texas
BACKGROUND: Cancer is one of the most widespread and deadly diseases in recent history. Cancer-cachexia is a systemic, metabolic disorder that greatly disrupts the patient’s energy balance, causing uncontrollable weight and, specifically, skeletal muscle loss. This cancer-induced cachexia is …
Reduced Skeletal Muscle Satellite Cell Number Alters Muscle Morphology After Chronic Stretch But Allows Limited Serial Sarcomere Addition, Matthew C. Kinney, Sudarshan Dayanidhi, Peter B. Dykstra, John J. Mccarthy, Charlotte A. Peterson, Richard L. Lieber
Reduced Skeletal Muscle Satellite Cell Number Alters Muscle Morphology After Chronic Stretch But Allows Limited Serial Sarcomere Addition, Matthew C. Kinney, Sudarshan Dayanidhi, Peter B. Dykstra, John J. Mccarthy, Charlotte A. Peterson, Richard L. Lieber
Physiology Faculty Publications
Introduction: Muscles add sarcomeres in response to stretch, presumably to maintain optimal sarcomere length. Clinical evidence from patients with cerebral palsy, who have both decreased serial sarcomere number and reduced satellite cells (SCs), suggests a hypothesis that SCs may be involved in sarcomere addition. Methods: A transgenic Pax7‐DTA mouse model underwent conditional SC depletion, and their soleii were then stretch‐immobilized to assess the capacity for sarcomere addition. Muscle architecture, morphology, and extracellular matrix (ECM) changes were also evaluated. Results: Mice in the SC‐reduced group achieved normal serial sarcomere addition in response to stretch. However, muscle fiber cross‐sectional …