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Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury, Jeffrey J. Szymanski
Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury, Jeffrey J. Szymanski
Wayne State University Dissertations
The final cause of death in most patients revived after cardiac arrest is ischemia and reperfusion (I/R) injury in the brain. Survival after brain I/R injury depends on the expression of new stress response proteins such as heat shock protein 70 (HSP70). Little is known about why recovering neurons are able to express new stress response proteins while neurons that will die can transcribe RNA but do not translated protein in early reperfusion. Previous studies suggested that the mRNA-binding protein HuR may regulate hsp70 mRNA in reperfused neurons through a novel cytoplasmic structure, the mRNA granule. To determine the roles …