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Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury, Jeffrey J. Szymanski
Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury, Jeffrey J. Szymanski
Wayne State University Dissertations
The final cause of death in most patients revived after cardiac arrest is ischemia and reperfusion (I/R) injury in the brain. Survival after brain I/R injury depends on the expression of new stress response proteins such as heat shock protein 70 (HSP70). Little is known about why recovering neurons are able to express new stress response proteins while neurons that will die can transcribe RNA but do not translated protein in early reperfusion. Previous studies suggested that the mRNA-binding protein HuR may regulate hsp70 mRNA in reperfused neurons through a novel cytoplasmic structure, the mRNA granule. To determine the roles …
Sex Differences In The Cardiac Beta-Adrenergic Receptor Contractile Response, Victoria Mcintosh
Sex Differences In The Cardiac Beta-Adrenergic Receptor Contractile Response, Victoria Mcintosh
Wayne State University Dissertations
Premenopausal females are at a reduced risk for developing cardiovascular disease as compared to males; this sex difference is not present following menopause. &beta-adrenergic receptors are pharmaceutical targets in the treatment of cardiovascular disease, and sex differences in &beta-adrenergic responsiveness have been demonstrated. However, limited studies have addressed the mechanism(s) underlying these differences. To investigate these sex differences, studies were performed using isolated perfused hearts from male, intact female and ovariectomized female mice, as well as male and female ventricular myocytes. Female hearts exhibited blunted contractile responses to the &beta-adrenergic receptor agonist isoproterenol (ISO) compared to males but not ovariectomized …